This is an automatically translated article.
Liozin medicine has alphachymotrypsin ingredient which belongs to the group of antipyretic analgesics and non-steroidal anti-inflammatory drugs. The drug is indicated in the treatment of inflammation or loosening respiratory secretions. However, using Liozin can experience some unwanted side effects. Therefore, patients need to learn carefully and consult a doctor before using the drug.
1. Mechanism of action of Liozin
What is Liozin? The drug Liozin has alpha chymotrypsin which belongs to the group of proteolytic enzymes that aid in surgery. This enzyme is prepared by activating chymotrypsinogen extracted from bovine pancreas. The mechanism of action of the enzyme is selective catalysis with peptide bonds adjacent to aromatic amino acids. Moreover, this enzyme will be used in ophthalmology to easily remove cloudy eye nucleus, while reducing trauma in the eye. The enzyme does not resolve adhesions between the lens and other structures of the eye. When using enzymes at a ratio of 1:5000, it usually takes about 2 minutes to decompose the suspensory ligament, but when done with a solution of 1:10000, the time increases to about 4 minutes. The enzyme alpha chymotrypsin is also used in the treatment of reducing inflammation and soft tissue edema caused by abscesses and ulcers, or from trauma. Besides, they help to loosen the respiratory secretions of people with asthma, bronchitis or other lung diseases and sinusitis.
2. Indications and contraindications to the use of Liozin
Uses of Liozin: Liozin is indicated in anti-inflammatory treatment with specific treatment of edema after trauma or surgery, such as soft tissue damage, acute trauma, sprains, hematomas , bleeding bruises, infections, cramps, sports injuries... In addition, Liozin is also used to loosen secretions in the respiratory tract in patients with asthma, bronchitis, sinusitis or other lung diseases.
However, Liozin drug may be contraindicated in some cases such as: patients who are allergic to the drug's components or alphachymotrypsin enzyme contraindicated in patients with alpha 1 antitrypsin reduction, or lung disease. Chronic obstructive pulmonary disease.
3. Dosage and usage of Liozin
Dosage of Liozin can be used for oral treatment in two cases: Swallow 2 Liozin tablets equivalent to 4.2mg or 4200 USP chymotrypsin units, the frequency is from three to four times per day. Or can soak under the tongue from 4 to 6 tablets per day and divided into several times.
In the treatment of ophthalmology, the drug can be used by: before the incision can dilate the pupil with a suitable pupil dilator, anesthetic or anesthetic can be applied. But must mix lyophilized chymotrypsin for eye use as indicated. Dosage for this case is usually irrigated into the back of the eye with a concentration of 1 to 2 ml of chymotrypsin solution containing 150 units/ml or 75 units/ml. Once the iris is removed or the iris is opened and sutures are placed, wait 2 to 4 minutes and then irrigate the posterior chamber with at least 2 ml of diluent. If the ligament is still intact, you can add 1 to 2 ml of solution through the iridotomy and wait for another 2 to 4 minutes and then irrigate the posterior chamber with at least 2 ml of dilute solution.
The above dosage is for reference only. Patients should consult a doctor to be able to use the drug effectively. Because each person will have different health and disease severity.
In case the patient accidentally takes an overdose of Liozin than prescribed and has some signs of unwanted side effects, it is necessary to take the patient to the nearest emergency medical facility for assistance. timely medical assistance to help patients overcome dangerous conditions.
If you miss a dose of Liozin while taking Liozin, you can use the missed dose as soon as you remember it. However, if the interval between the missed dose of Liozin and the next dose is close, the patient can skip the missed dose and take the next dose. Patients should also note that it is not recommended to double the dose of Liozin because it can cause drug overdose and unwanted side effects that affect the patient's current health.
4. Unwanted side effects and notes when using Liozin
Long-term use of Liozin drug has not yet clearly announced the side effects of the drug. However, patients with medical conditions should be cautious and consider carefully when using the drug.
With some specific cases, unwanted side effects may still occur during treatment with Liozin. Some studies have also shown that at commonly used doses of Liozin are not detected in the blood for 24 to 48 hours. Possible temporary side effects include a change in the color, consistency, and odor of the stool. However, these signs may disappear when drug treatment is stopped or when the dose is reduced. In some other special cases, there may be digestive disorders, flatulence, heaviness in the abdomen, diarrhea, constipation or nausea...
The chymotrypsin component in Liozin has antigenic properties, so after When injected intramuscularly may experience some allergic reactions.
In the case of using Liozin in high doses, it may cause some allergic reactions such as redness of the skin.
Interaction of Liozin: Liozin can be used in combination with other enzyme drugs to increase the effectiveness of treatment. In addition, a proper diet or vitamin and mineral supplements may be recommended to help increase the enzyme activity in Liozin. However, there are some foods such as jojoba beans, wild soybeans and tomatoes that can inhibit the activity of the enzyme alphachymotrypsin. However, the proteins in these foods can be inactivated by heating.
Some other notes because the alphachymotrypsin component in Liozin can be well tolerated and does not cause significant side effects for patients during use. Patients who may not be treated with this enzyme include those with an inherited blood clotting disorder - hemophilia or those with a non-hereditary clotting disorder or those who have recently undergone surgery.
Above is all important information about Liozin drug. If there is a problem that requires consultation, the patient can directly discuss with the treating doctor to get the appropriate indications.
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