This is an automatically translated article.
Drug Lamzidocom is an anti-parasitic, anti-viral and anti-infective drug. The drug has two active ingredients, Lamivudin and Zidovudin. The drug is indicated in the treatment of HIV infection, increasing immunity.
1. What is Lamzidocom?
Lamzidocom drug belongs to the group of drugs that treat parasites, anti-infectives, antivirals and antifungals. Is a combination antiretroviral drug indicated for the treatment of HIV infection, increasing immunity.
Lamzidocom drug is prepared in the form of film-coated tablets. Packing specification is box of 6 blisters x 10 tablets, box of 10 blisters x 10 tablets, box of 1 bottle of 60 tablets.
The main ingredients in the drug are 2 active ingredients Lamivudin 150mg and Zidovudin 300mg. Excipients with sufficient content of 1 film-coated tablet.
2. What are the effects of Lamzidocom?
Lamzidocom is a combination drug with 2 active ingredients Lamivudin and Zidovudin. Lamivudine and zidovudine are nucleoside analogues that are both active against HIV type and 2 (HIV - 1, HIV - 2). The combination of 2 substances showed a synergistic effect and reduced drug resistance, reducing the virus concentration in plasma by about 10 times, the effect lasted more than 1 year. In addition, active ingredient Lamivudin also helps fight hepatitis B virus (HBV).
Lamzidocom indications:
Lamzidocom is a combination antiretroviral drug indicated for the treatment of HIV infection, increasing immunity for the following subjects: Adults and children 12 years of age and older.
3. How to use Lamzidocom:
3.1. How to use Lamzidocom: Patients use Lamzidocom orally.
3.2. Dosage of Lamzidocom: Adults and children over 12 years: The recommended dose is 1 tablet, 2 times daily, 12 hours apart. Children: Depending on body weight as follows: Weight from 21 - 30 kg: Take 1⁄2 tablets in the morning and 1 capsule in the evening, in case of intolerance, you can take 1⁄2 tablets, 3 times per day. Weight from 14 - 21 kg: Take 1⁄2 tablets, 2 times per day, 12 hours apart. Weight less than 14 kg: Do not use combination drug Lamzidocom for this subject. Patients with renal impairment: Avoid using the combination drug for patients with renal impairment with creatinine clearance less than 50 ml/min and it is recommended to use Lamivudine and Zidovudine separately so that the dose can be adjusted according to the case. Hepatic Impairment: Zidovudine dose adjustment is required. Lamivudine and Zidovudine alone are recommended in patients with severe hepatic impairment. Patients with anemia or agranulocytosis: It is recommended to use 2 separate drugs to adjust the dose of Zidovudine appropriately. Dosage information is for reference only. To be able to use it most accurately, patients need to consult a specialist pharmacist or doctor.
3.3. How to deal with forgetting, overdosing Missed dose:
If you miss a dose of Lamzidocom, add it as soon as you remember. Usually can take the medicine within 1-2 hours than prescribed in the prescription. However, if it is too far from the time you should take it, skip the missed dose and take the next dose exactly as directed by the qualified pharmacist or doctor in charge. Never use a double dose at the same time.
Overdosage:
Very little is known about Lamivudine overdose, although in the event of an overdose, no clinical signs or symptoms were observed, and blood tests were normal. There is no antidote. There are no specific data on how to exclude by peritoneal dialysis or hemodialysis.
Several literature reports of acute zidovudine overdose in children and adults indicate that symptoms include nausea and vomiting. Blood changes are usually not severe and of short duration. Some patients have nonspecific CNS symptoms such as headache, dizziness, somnolence, lethargy, and confusion.
Treatment of overdose:
When symptoms appear or any suspicion of an overdose of Lamzidocom, it is necessary to stop the drug, immediately notify the treating doctor.
Measures to be applied: Gastric lavage or increased elimination with multiple doses of activated charcoal may be effective. Supportive treatment with blood transfusion, combined with vitamin B12 to help prevent anemia, treatment of convulsions with Diazepam or Lorazepam.
3.4. Lamzidocom is contraindicated: Lamzidocom is contraindicated in the following cases:
Cases where the patient is hypersensitive to active ingredients Lamivudin, Zidovudin or to one of the ingredients of the drug. Patients with neutrophils less than 0.75 x 109/liter or hemoglobin less than 75g/liter.
4. Notes when using Lamzidocom
4.1 Warnings and cautions when using Lamzidocom: For all patients, Lamzidocom should be used with caution, especially in obese women, with liver disease or at risk of liver disease, people with kidney failure and people elderly. In children with a history of pancreatitis or risk factors for developing pancreatitis, when lamivudine and zidovudine alone are used together, the dose can be adjusted accordingly as directed by a qualified pharmacist or doctor. Use with caution in patients with a history of cirrhosis due to chronic hepatitis B, because if Lamivudine is discontinued, there is a risk of recurrent hepatitis. Pregnancy and breast-feeding: Do not use the drug for women in the first 3 months of pregnancy. Driving or operating machinery: Use with caution in this person because the drug can cause dizziness. When used for subjects that need to adjust the dose, Lamivudin and Zidovudine should be prescribed separately so that the dose can be adjusted appropriately according to the guidance of the doctor. Concomitant administration of Lamivudine and Stavudine should be avoided. Patients should be advised that therapy with this drug does not reduce the risk of transmitting HIV to others through sexual contact or blood-borne infection. It is necessary to monitor the clinical signs, laboratory tests on the progress of HIV to change the treatment regimen when necessary. 4.2 Side effects when using Lamzidocom: When using Lamzidocom, you may encounter the following unwanted side effects:
Due to Lamivudin:
Headache, insomnia, fatigue, dizziness, depression, fever , so cold. Nausea, vomiting, loss of appetite, diarrhea, abdominal pain, dyspepsia, increased amylase. Peripheral neuropathy, myalgia, arthralgia. Symptoms of runny nose, cough. Rash. Neutropenia, anemia. Increase AST, ALT. Rare: Pancreatitis, thrombocytopenia, hyperbilirubinemia. Due to Zidovudine:
Megaloblastic anemia, agranulocytosis, neutropenia. Nausea, vomiting, indigestion, diarrhea. Rash, nail pigmentation, alopecia, epidermal necrolysis. Polymyositis syndrome. 4.3 Interactions, drug incompatibilities Lamzidocom: Consider co-administration of Lamzidocom with alcohol, alcoholic or fermented beverages, tobacco.
Adjust dose in patients with renal impairment because Trimethoprim / Sulfamethoxazole increases the bioavailability of Lamivudine by 44%, due to the same elimination mechanism.
Zidovudine has an in vitro contrasting effect with Ribavirin, Stavudine, so the combination should be avoided.
Co-administration of Zidovudine with Rifampicin reduces the bioavailability of Zidovudine by 4 - 48%.
Concomitant use with nephrotoxic, cytotoxic or myelosuppressive drugs such as Dapson, Pyrimethamine, Ganciclovir, Flucytosin increases the risk of adverse reactions.
Concurrent use of Paracetamol increases blood complications, increases the risk of anemia.
4. 4 Lamzidocom drug storage: Store the medicine at a temperature below 30°C, avoid direct sunlight, avoid moisture, keep in a cool and dry place.
Above is all necessary information when using Lamzidocom. Lamzidocom is a prescription drug, so patients should not take it on their own and stop taking it without the permission of the treating doctor.
