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Lacovir drug is made in the form of a topical cream, with the main ingredient in 1 tube of 5g containing 50mg of Acyclovir. So what is the effect of Lacovir and how is it used?
1. Effects of Lacovir
The main ingredient of Lacovir is acyclovir, which is a nucleoside analogue (acycloguanosin), which has a selective effect on cells infected with the Herpes virus. To be effective, acyclovir must be phosphorylated to the active form, acyclovir triphosphate.In the first stage, acyclovir is converted to acyclovir monophosphate by a viral enzyme called thymidinekinase, which is then converted to acyclovir diphosphate and triphosphate by a number of other cellular enzymes. Acyclovir triphosphate inhibits viral DNA synthesis and viral replication without affecting normal cellular metabolism.
The effect of Acyclovir is strongest against Herpes simplex virus type 1 (HSV - 1) and less effective against Herpes simplex virus type 2 (HSV - 2), Varicella zoster virus (VZV); Acyclovir has the weakest effect on cytomegalovirus (CMV).
Clinically, Acyclovir has not been found to be effective in patients with CMV infection. The efficacy of acyclovir against Epstein Barr virus is still unknown. During the course of treatment, some drug-resistant strains of virus and Herpes simplex virus latent in the lymph nodes were not destroyed.
Acyclovir has good effect in the treatment of severe encephalitis caused by HSV-1 virus, the mortality rate in this case can be reduced from 70% to 20%. In some patients who are cured, serious complications of the disease are also reduced. Milder forms of encephalitis caused by HSV-2 can also be treated well with acyclovir.
2. Indications and contraindications of Lacovir
Lacovir is indicated in the following cases:
Herpes of the lips with onset and recurrence. Genital herpes onset and recurrence. Lacovir is contraindicated in the following cases:
People with hypersensitivity to Acyclovir. Hypersensitivity to Propyleneglycol. Precautions while using Lacovir:
Lacovir is not recommended for use in mucous membranes, such as the inside of the mouth, eyes or vagina. Special care should be taken to avoid getting Lacovir into the eyes. The available data on the use of drugs containing acyclovir in pregnant women are limited. Therefore, the benefits of treatment should be carefully weighed against the possible adverse effects for the fetus before using Lacovir. Lacovir should be used with caution in lactating women.
3. Dosage and how to use Lacovir
Lacovir drug is used by applying topically to the skin, applying a sufficient amount of medicine to the damaged skin. Lacovir cream should be applied to damaged or impending skin areas as soon as possible after infection with the virus.
Dosage of Lacovir should be according to the doctor's prescription, the reference dose for adults and children is to apply the drug 5 times a day about 4 hours apart, not at night.
The treatment of the disease in the stages of relapse is especially important, it is necessary to start taking Lacovir right in the prodromal phase or when lesions begin to appear.
Should continue treatment with Lacovir within 5 days. If the lesion has not healed, treatment with Lacovir can be extended for up to 10 days.
4. Lacovir side effects
During the use of Lacovir, you may encounter some side effects of the drug, including:
A burning and stinging sensation may occur when applying the medicine. A rash . Itchy. If you see any unusual symptoms while using Lacovir, you should notify your doctor or go to a medical facility for timely treatment.
Above is all information about Lacovir, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Lacovir is a prescription drug, so patients should absolutely not buy drugs to treat at home because they may experience unwanted side effects.
