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Ketoconazole 200mg has the effect of treating local fungal diseases, systemic fungi, candidiasis in the skin, mucous membranes,... So what is Ketoconazole 200mg? What precautions should be taken when using this drug? Let's find out the necessary information about the drug Ketoconazole 200mg through the article below.
1. Uses of Ketoconazole 200mg
Indications:
Local fungal infections (after no results of local treatment) Chronic and severe skin and mucosal candidiasis. Chronic urinary and vaginal candidiasis. Gastrointestinal fungal infections. Fungal infections of the skin and nails. Systemic fungal infections include Candida, Blastomyces, Coccidioides, Histoplasma, Paracoccidioides. Prophylaxis of fungal infections in immunocompromised patients. Dosage - How to take
Drink during or after eating.
Adults: Take 1-2 tablets, once a day.
Children:
children weighing 15-30kg: take 1/2 tablet, once a day children weighing over 30kg: the same dose as adults. Period of use from 2 weeks to several months. Treatment should be continued and continued for at least 1 week after all symptoms have disappeared and cultures have been negative.
Overdose and management
In case of overdose, supportive measures should be applied including gastric lavage with Sodium bicarbonate.
2. Side effects of Ketoconazole 200mg
Nausea, abdominal pain, constipation, flatulence, gastrointestinal bleeding, diarrhea, headache, dizziness,... Transient decrease in Testosterone. Inform your doctor about any unwanted effects you may experience while using the drug.
3. Drug interactions
Avoid taking Ketoconazole with drugs metabolised in the liver such as: Terfenadine, Astemizole, Cisapride, Domperidone, Midazolam, and Triazolam, Domperidone, Pimozide, Quinidine, statins such as Atorvastatin and Simvastatin. Drugs that reduce gastric acid such as antacids, antacids, H2 antihistamines, proton pump inhibitors or Sucralfate: reduce the absorption of Ketoconazole. These drugs should be taken at least 2 hours after taking Ketoconazole. Rifampicin and Isoniazid: reduce the serum concentration of Ketoconazole. Cyclosporine: Ketoconazole increases the blood concentration of Cyclosporine.
4. Notes when using Ketoconazole 200mg
Contraindications
Hypersensitivity to one of the components of the drug. Women who are pregnant or breastfeeding. Acute or chronic liver disease. Notes/Precautions
Liver function tests are required during long-term treatment with Ketoconazole. Treatment should be discontinued when signs of liver disease appear. Caution is advised during prolonged treatment in children because Ketoconazole inhibits the synthesis of steroids and the metabolism of Vitamin D.
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