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Apidogrel belongs to the group of cardiovascular drugs with the main ingredient being Clopidogrel and is indicated in the control and prevention of thromboembolic disorders with myocardial infarction, stroke... Patients need to learn carefully. information and adherence to treatment for maximum effectiveness.
1. Mechanism of action of the drug Apidogrel
Apidogrel contains clopidogrel, which selectively inhibits the binding of adenosine diphosphate to its platelet receptor and leads to adenosine diphosphate-mediated activation of the glycoprotein complex. Thus, this compound has an inhibitory effect on platelet aggregation. The biotransformation of this compound is required for the induction of inhibition of platelet aggregation, but the active metabolite of the drug has not been isolated. Furthermore, clopidogrel acts by irreversibly modifying the platelet adenosine diphosphate receptor and causing the platelets to bind to clopidogrel to affect the latter stage.2. Indications and contraindications to the use of Apidogrel
What does Apidogrel do? Apidogrel is indicated for the primary prevention of thromboembolic disorders such as myocardial infarction, stroke, and peripheral arterial disease. Or used in the control and secondary prevention of atherosclerotic patients with recent stroke, or confirmed peripheral vascular active myocardial infarction.
3. Dosage and usage of Apidogrel
Apidogrel is used by mouth, the patient can be with or without meals. Dosage of the drug depends on the severity of the disease of each patient.
In the treatment of patients with a history of atherosclerosis, the recommended dose is 1 tablet of 75mg per day. Dose used in prophylaxis to prevent thromboembolic disorders such as myocardial infarction, arteriosclerosis. Peripheral pulse, stroke is 1 tablet 75mg per day. For the treatment of acute coronary syndromes with unstable angina, non-Q-wave myocardial infarction, the initial dose is 300 mg as a single dose and the maintenance dose is 75 mg per dose. day. Note: The above recommended therapeutic dose for Apidogrel is for reference only. Therefore, before using Apidogrel, patients should consult a doctor.
4. Management of missed dose and overdose of Apidogrel
If you miss a dose of Apidogrel, take the missed dose as soon as you remember. However, if the interval between the missed dose of Apidogrel and the next dose is too close, skip the missed dose. Patients should not double the dose of Apidogrel, because it can cause an overdose. To overcome the situation of missed doses, patients can set an alarm or ask a loved one to remind them.
In case of accidentally using Apidogrel drug in excess of the prescribed dose and showing some unwanted signs, it is necessary to take the patient to the emergency room or to see a doctor immediately for treatment. earliest time.
5. Unwanted side effects when using Apidogrel
Apidogrel can cause some unwanted side effects during treatment. However, with each case, Apidogrel can occur in varying degrees from mild to severe.
Some common side effects caused by Apidogrel include: gastrointestinal upset with diarrhea, abdominal pain, indigestion and nausea, skin allergy with erythema and itching,... These side effects may occur at the start of treatment or after increasing the dose of Apidogrel. Usually, side effects from apidogrel can be transient or subside over time.
However, in some cases, Apidogrel can cause serious unwanted side effects with rare reactions. These reactions may appear within minutes of using Apidogrel or may be longer within a few days. In the presence of serious side effects such as: chest tightness, epistaxis, gastrointestinal bleeding, peptic ulcer, neutropenia or severe agranulocytosis, thrombocytopenia, rash bleeding due to thrombocytopenia, aplastic anemia, kidney disease such as nephritic syndrome, loss of taste, acute arthritis... the patient should stop using Apidogrel and should get medical help right away. instantly.
Some notes during the use of Apidogrel
Pregnant and nursing women should be cautious when using Apidogrel. Patients should consult a doctor, and carefully analyze the benefits and risks before using the drug. Apidogrel may change how it works and increase its side effects. Therefore, to avoid this situation, the patient should provide the doctor with a list of previously used drugs including prescription drugs, non-prescription drugs, herbs... Above is important information about Apidogrel drug. Patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to achieve the best effect.
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