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Article by Pharmacist Duong Thanh Hai - Clinical Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital
Nattokinase drugs are often produced in the form of functional foods and are commonly used in people with cardiovascular diseases such as stroke, angina pectoris, deep vein thrombosis, atherosclerosis...
1. What is Nattokinase?
Nattokinase is a natural enzyme extracted from a food called Natto - a traditional Japanese dish from soybeans. Natto is also considered a folk remedy for diseases of the heart and blood vessels.
Natto is a food rich in protein, vitamins and minerals, but most of the health benefits of natto as well as its distinctive taste are due to the enzyme nattokinase. This enzyme is produced during the fermentation of natto by a species of bacteria called Bacillus subtilis.
2. What does nattokinase do?
Studies in experimental and laboratory animal models show that nattokinase has fibrinolytic effects, inhibits platelet aggregation leading to blood thinning and clot dissolution. Laboratory studies also show that natto extract has anti-atherosclerotic and lipid-lowering effects. Some other studies suggest that nattokinase may help lower blood pressure.
Nattokinase is often produced as a functional food and is commonly used in people with cardiovascular diseases such as heart disease, hypertension, blood fat, stroke, angina pectoris, deep vein thrombosis. , atherosclerosis, hemorrhoids, varicose veins and peripheral arterial disease (PAD). However, there are few clinical studies demonstrating the efficacy of nattokinase in these conditions.
Approximately 10 clinical studies have been performed to evaluate the effectiveness of nattokinase. The first clinical study evaluated the fibrinolytic effects in healthy volunteers, followed by another study in Japan that evaluated the efficacy of nattokinase in preventing stroke progression in patients with fibrinolysis. acute ischemic stroke. Preliminary study results suggest beneficial effects of nattokinase. Another study found that nattokinase supplementation reduced the risk of blood clots after long flights and helped reduce narrowing of the arteries. In addition, there are also a number of clinical studies investigating the antihypertensive, anti-atherosclerotic and lipid-lowering effects of nattokinase. Due to the limited amount of evidence from clinical studies, it is not possible to fully draw conclusions about the effectiveness of nattokinase.
3. How to use nattokinase
Regarding the use of nattokinase , the optimal dose has not been clearly established for the above conditions. The usual oral dose of nattokinase is 100-200 mg/day. In addition, the quality and active ingredients in functional products can vary from manufacturer to manufacturer. This makes it very difficult to recommend a standard dosage.
Người bệnh nên uống thuốc Nattokinase theo hướng dẫn của bác sĩ
4. What are the risks of nattokinase?
To date, there are no concerns about toxicity in nattokinase users. Oral administration of nattokinase has been shown to be safe for use for up to 6 months.
However, caution should be exercised in the following groups of people:
Pregnancy and breast-feeding: There is not enough reliable information on the safety of nattokinase use and should be avoided. Bleeding disorders: Nattokinase may make bleeding disorders worse. People with low blood pressure: Nattokinase can lower blood pressure, so it should be used with extreme caution. Patients with surgery: Nattokinase may increase the risk of excessive bleeding during or after surgery. It can also make blood pressure difficult to control during surgery. Nattokinase should be discontinued at least 2 weeks prior to surgery. In addition, because nattokinase reduces blood clotting, some medications that may increase the risk of bruising and bleeding when taken together with nattokinase, such as aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs), and anticoagulants, are also known to increase the risk of bleeding. enoxaparin (Lovenox) heparin, warfarin... Therefore, consult your doctor or pharmacist for advice on appropriate management.
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