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Idaroxy is a broad-spectrum antibiotic that is used orally to treat infections caused by susceptible bacteria and has no effect on viruses or fungi.1. What effects does Idaroxy have?
The main ingredient of Idaroxy is Doxycycline (as Doxycyclin hyclat) 100mg.Doxycycline is an antibiotic with bacteriostatic effect. Doxycycline is a drug that acts on bacterial protein synthesis. Doxycycline crosses the lipid bilayer of bacterial cells and enters the inner cytoplasm by means of an energy-dependent active transport system. Once inside the cell, doxycycline inhibits protein synthesis by binding to the 30S subunit of the ribosome and preventing the addition of amino acids to the growth of the peptide chain. Doxycycline has a broad spectrum of antibacterial activity against aerobic and anaerobic bacteria; Gram-positive and Gram-negative, active both against some drug-resistant bacteria with cell wall effects such as Rickettsia, Coxiella burnetii, Mycoplasma pneumoniae, Chlamydia spp., Legionella spp., Ureaplasma, some atypical Mycobacterium and Plasmodium spp.
2. Indications and contraindications of the drug Idraroxy
2.1. Point
Idraroxy is indicated in cases of bacterial infections caused by susceptible bacteria:Pneumonia : Pneumonia caused by bacteria such as Pneumococcus, Streptococcus, Staphylococcus, Haemophilus influenzae. Other respiratory tract infections: Pharyngitis, tonsillitis, rhinosinusitis, otitis media, bronchitis caused by beta-hemolytic Streptococcus, Staphylococcus, Pneumococcus, Haemophilus influenzae. Urinary tract infections: Nephritis - pyelonephritis, cystitis, urethritis caused by bacterial strains such as Klebsiella aerobacter, E. coli, Enterococcus, Staphylococcus, Streptococcus. Skin and soft tissue infections: Acne, impetigo, boils, cellulitis, abscesses, wound infections, periungitis caused by Staphylococcus aureus and albus. Streptococcus, E.coli and Klebsiella aerobacter group. Gastrointestinal infections: Infections caused by Shigella, Salmonella and E.coli.
2.2. Contraindications
Hypersensitivity to any component of the drug and hypersensitivity to tetracyclines. Combination with retinoids. Children < 8 years old. Pregnant women and lactating women.3. Dosage and how to use Idaroxy
3.1. How to use
The drug is taken orally. Should be taken during or after a meal with plenty of water in an upright or standing position. If stomach irritation should be taken with food.3.2. Dosage
Adults:The single loading dose for acute infections is 2 tablets on the first day of treatment, followed by a maintenance dose of 1 tablet once daily at the same time of day. Should choose to drink at night before going to bed to reduce gastrointestinal irritation. If the infection is severe: adults take 2 tablets / time / day during the course of treatment. Treatment of acute gonococcal infection: Take 2 tablets at the beginning and 1 tablet in the evening before bed on the first day, then 1 tablet and take 2 times a day for 3 days. Treatment of uncomplicated urethral infections, infections of the inside of the cervix or vagina caused by Chlamydia trachomatis and Ureaplasma urealyticum: Take 1 tablet twice a day for at least 10 days. Children over 8 years old: Oral dose of 4mg/kg/day. Single or divided doses can be used.
Duration of treatment: When used to treat Streptococcus infections, treatment should be 10 days to prevent the risk of rheumatic fever or glomerulonephritis.
No dose reduction is required in patients with renal impairment.
4. Side effects of the drug Idaroxy
When taking Idaroxy you may also experience undesirable effects, including:Hypersensitivity reactions, including anaphylaxis , allergic purpura; hypotension, pericarditis, angioedema, exacerbation of systemic lupus erythematosus, dyspnea, tachycardia and urticaria. However, these reactions are rare. Increased risk of non-susceptible and parasitic infections: As with all antibiotics, Clostridium difficile overgrowth causes pseudomembranous colitis and dermatitis, and Candida overgrowth in skin and genital area. Hemolytic anemia, thrombocytopenia, decreased neutrophil index, eosinophilia and porphyria. When taking tetracycline antibiotics for a long time, a dark brown discoloration of thyroid tissue can be produced. Headache ; diplopia and diplopia, which can cause permanent vision loss, have been reported; Tinnitus; Gastrointestinal symptoms that are usually mild and rarely require discontinuation for treatment include: Abdominal pain, stomatitis, anorexia, nausea and vomiting, diarrhea, dyspepsia, and rarely dysphagia. Esophagitis and esophageal ulcers, tetracycline antibiotics can cause tooth discoloration and enamel hypoplasia, but usually only after long-term treatment. Hepatobiliary disorders: Transient elevation of liver enzymes on laboratory tests, rarely hepatitis, jaundice, liver failure and pancreatitis. Rash includes maculopapular and erythematous rash, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis, nail exfoliative, photosensitivity. Muscle and joint pain; vaginitis; Increased urea in the blood. When experiencing side effects of Idaroxy, you need to stop using and notify your doctor or go to the nearest medical facility for timely treatment.
Precautions while taking Idaroxy
Liver function tests should be performed periodically in patients receiving high or prolonged doses of the drug. If possible, the concomitant use of doxycycline with other agents known to cause hepatotoxicity should be avoided. When using antibiotics can cause superinfection of non-susceptible bacteria; Therefore, the patient should be carefully monitored. There is evidence that doxycycline may have a weaker effect on the gut microbiota than other tetracyclines. Some patients with hypertension may have a photodynamic response to sunlight during doxycycline therapy. If this reaction occurs during treatment or any other allergic reaction, the drug should be discontinued. To prevent this from happening, you should avoid sun exposure and use appropriate shielding measures when taking this medicine. Increased intracranial pressure along with fontanelle has been observed in children receiving therapeutic doses of tetracyclines. Although the mechanism underlying this phenomenon is unknown, signs and symptoms disappear rapidly upon discontinuation of the drug without sequelae. Esophageal injury including inflammation and ulceration of the esophagus has rarely been reported in patients receiving oral doxycycline. If such lesions are present, the drug should be discontinued until the wound has healed. To minimize the risk of damage to the esophagus, it is recommended to drink with plenty of water and not to suck or break the capsule before taking it. As with other tetracyclines, Doxycycline can form a stable calcium complex in tissues of a skeletal nature. Therefore, the use of tetracycline drugs during the period of tooth development (pregnant women, infants and children under 8 years of age) can cause permanent tooth discoloration, this undesirable effect is common. more variable with long-term drug use or short-term but repeated use. Drug Interactions: Concomitant administration of Doxycycline with antacids containing aluminum, calcium, or magnesium may reduce the effectiveness of the antibiotic; if taken with iron and bismuth subsalicylate, may reduce the bioavailability of doxycycline; Concomitant use with barbiturates, phenytoin and carbamazepine may reduce the half-life of doxycycline, increase the effect of the drug, increase the risk of side effects; With anticoagulant warfarin may increase the effect of anticoagulants. Storage: The medicine should be stored in a cool place, away from sunlight and at a temperature below 30 degrees Celsius. Keep out of reach of children. Above is information about the drug Idaroxy, this is a very common antibiotic used in the treatment of acne with bacterial superinfection, but also used in other sensitive bacterial infections. To use the drug safely and effectively, you should strictly follow the instructions of your doctor about the dose and method of use.
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