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Trimetazidine is a commonly used active ingredient for the treatment of inadequately controlled stable angina. Trimetazidine is present in many different medicinal products, including Hismedan 20mg.
1. What is Hismedan 20mg?
Trimetazidine is an active ingredient that works by inhibiting beta oxidation of fatty acids (by inhibiting enzymes in ischemic cardiomyocytes). The energy obtained in glucose oxidation requires less oxygen consumption than in beta oxidation, so promoting glucose oxidation, inhibiting beta oxidation will help optimize cellular energy processes. cells, thereby maintaining proper energy metabolism during ischemia.
2. What is the effect of Hismedan?
Hismedan 20mg is indicated for use in the following cases:
Use of Hismedan 20mg for adults as an adjunct to or adjunctive therapy to existing therapy for symptomatic treatment in patients with stable angina full control; Use Hismedan 20mg for patients intolerant to other therapies for angina. Hismedan 20mg is contraindicated for use in the following cases:
Hypersensitivity to the active ingredient of Hismedan 20mg or any of the excipients listed in the product's formula; Patients with Parkinson's disease, with Parkinson's symptoms such as tremor, restless legs syndrome and other related movement disorders; Severe renal impairment (creatinine clearance < 30 mL/min).
3. Dosage of Hismedan 20mg
Hismedan 20mg is used orally with the usual dosage for adults as follows: 1 tablet / time, 3 times / day, patients should take Hismedan 20mg with meals.
Patients with moderate renal impairment (creatinine clearance 30-60 mL/min): The recommended dose of Hismedan 20 mg is 1 tablet x 2 times/day, morning and evening, taking Hismedan 20 mg with meals .
Elderly patients (may be more sensitive to Trimetazidine active ingredient than normal people due to age-related decline in renal function) with moderate renal impairment, the recommended dose is 1 tablet x 2 times/ day, morning and evening with meals, however caution should be exercised when calculating the dose of Hismedan 20mg for elderly patients.
Safety and effectiveness of Trimetazidine active ingredient in patients under 18 years of age have not been studied, so there are currently no data on the dose of Hismedan 20mg in this patient population.
Note: The above dose of Hismedan 20mg is for reference only, the specific dose of Hismedan 20mg depends on the condition and progression of the disease, it is best to have a suitable dose, patients need to refer to it. consult a doctor or medical professional.
If an overdose of Hismedan 20mg, try to induce vomiting and take the patient to the nearest medical facility for bowel lavage.
4. Side effects of Hismedan 20mg
When using Hismedan 20mg, patients may experience common undesirable effects including:
On the nervous system: Hismedan 20mg may cause dizziness, headache; Effects on the stomach - intestines: Abdominal pain, diarrhea, nausea and vomiting, indigestion Side effects of Hismedan 20mg on the skin: Rash, itching, urticaria; Weak body. Rare side effects of Hismedan 20mg:
Side effects on the heart: Hismedan 20mg can cause palpitations, palpitations, extrasystoles, tachycardia; Vascular effects: Arterial hypotension, orthostatic hypotension, irritability, dizziness or falls, especially prone to occur in patients being treated with antihypertensive drugs, flushing.
5. Precautions when using Hismedan 20mg
When administering Hismedan 20mg to a pregnant or lactating woman, the benefit should be weighed against the risk. Trimetazidine may cause or worsen symptoms of Parkinson's disease (eg, tremor, slow/difficult movement, increased muscle tone), therefore patients, especially the elderly, should be examined and monitored. regular monitoring, if suspected the patient should be referred to a neurologist for appropriate examination; When experiencing movement disorders such as: Parkinson's symptoms, restless legs syndrome, tremor, unsteady gait, it is necessary to immediately stop using Hismedan 20mg. However, these cases are rare and usually reversible after stopping Hismedan 20mg about 4 months, if the above condition persists for more than 4 months after stopping Hismedan 20mg, the patient should consult a specialist. neurology; Caution should be exercised when prescribing Hismedan 20mg to patients with high trimetazidine sensitivity such as patients with moderate renal impairment, patients >75 years of age. Hismedan 20mg may cause dizziness and drowsiness, affecting the ability to drive and use machines. It is best not to take Hismedan 20mg during pregnancy There is not enough evidence for the presence of Trimetazidine in breast milk, so the best option is not to breastfeed while taking Hismedan 20mg.
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