Uses of Growpone

This is an automatically translated article.

Growpone is an injectable medication used in the treatment of certain medical conditions. So what is the use of Growpone and how to use it? Please read the article below.

1. What is the use of Growpone?

Growpone drug is prepared in the form of an injection solution with the main ingredient being Calcium gluconate 95.5mg/ml.
Table of calcium ion concentration in Growpone 10% injection solution is as follows:

Calcium gluconate is a readily available source of calcium ions and is used in the treatment of hypocalcaemia in diseases requiring a rapid increase in serum calcium ion concentrations. Besides, calcium gluconate can be used as an electrolyte replacement, an anti-hyperkalemia and hypomagnesaemia agent.
Calcium gluconate injection is for intravenous use only, must not be injected intramuscularly, into the heart muscle or under the skin (except in the treatment of hydrofluoric acid poisoning), nor should the drug escape from the lumen into the tissues. when injected because it can cause tissue necrosis and/or desquamation, abscess.
Growpone is indicated in the following cases:
Acute hypocalcemia such as neonatal tetani, hypoparathyroidism, remineralization after surgery for hyperparathyroidism or vitamin D deficiency; Prophylaxis of hypocalcemia during blood exchange; Patients treated with anticonvulsants for a long time (increased destruction of vitamin D); People with a calcium-deficient diet, especially during periods of increased calcium requirements such as: Growth period in children, pregnancy and lactation, the elderly; Hyperkalemia; Increased blood magnesium ; Patients with calcium blocker overdose or ethylene glycol poisoning; Patients after a large volume of blood transfusion containing calcium citrate causes hypocalcemia. Growpone is contraindicated in the following cases:
Ventricular fibrillation in cardiac resuscitation; Heart disease; Kidney disease; Hypercalcemia; Malignant tumors destroy bone; Severe urinary calcium; Osteoporosis due to immobility; The patient is taking the drug Digitalis.

2. Dosage and how to use Growpone

Growpone is given as a solution for intravenous injection, by direct injection into a slow vein or by continuous or drip intravenous infusion. Use of the drug is carried out by trained medical personnel.
Dosage of Growpone drug depends on the requirements of each patient. The recommended dose of Growpone for adults is as follows:
Treatment of hypercalcemia usually uses an initial dose of 7-14mEq for adults. This dosage may be repeated after 1 - 3 days if necessary; In spastic hypocalcaemia, a dose of 4.5 - 16mEq may be used until a response occurs; The maximum daily dose should not exceed 15g calcium gluconate equivalent to 67.5mEq calcium ion; Treatment of severe hypocalcaemia can use doses of 4.5 - 9.0 mEq of calcium and repeated as required under ECG control; For the treatment of hypermagnesaemia in adults, an initial dose of 7mEq intravenously is used, which may then be administered with subsequent doses adjusted according to the patient's response; In cardiac resuscitation, the recommended intravenous dose is 7-14mEq in adults and 0.5mEq in children. The recommended dose of Growpone for children is as follows:
For children and infants, a starting dose of 1-7mEq, respectively, and doses below 1mEq are commonly used to increase serum calcium levels. If necessary, the dose of Growpone can be repeated after 1 to 3 days; For children with hypocalcemia causing spasticity, the recommended dose is 0.5 - 0.7 mEq/kg body weight, repeated every 6 - 8 hours until a response is seen; Neonates with spasticity can be treated with the above dose with total daily doses in the range of 2.4mEq/kg; Growpone is contraindicated for subcutaneous and intramuscular injection in children. Overdosage of Growpone can cause hypercalcemia. Symptoms of hypercalcemia include: Anorexia, nausea, vomiting, abdominal pain, muscle weakness, mental confusion, thirst, constipation, polyuria, bone pain, renal calcium infection, kidney stones and in some cases Severe cases may appear arrhythmia, coma, cardiac arrest.

3. Growpone side effects

Growpone side effects are usually caused by the injection being given too quickly. Possible side effects of Growpone include:
Vasodilation; Lower blood pressure ; slow heart rate; Arrhythmia; Faint; Heart stop . When Growpone solution escapes into the surrounding tissue, it can cause necrosis and this is often the result of too fast intravenous administration. To avoid this side effect when given intravenously, Growpone should be injected slowly through a fine needle in a large vein.
Other possible side effects when using Growpone include:
Tingling sensation, feeling of oppression and heat wave, fishy taste after intravenous calcium salt injection; vein irritation; Slight increase in blood pressure, especially in the elderly or in patients with increased blood pressure during injection; Hypercalcemia is very rare with Growpone alone, but may occur when high doses are given to patients with chronic renal failure. Since hypercalcemia may be more dangerous than hypocalcaemia, overdose should be avoided. You need to tell your doctor right away about the side effects you experience while using Growpone.

4. Interactions with other drugs

Cardiac Glycosides: The effect on cardiac contractility and toxicity of cardiac glycosides and Growpone are synergistic. Arrhythmias may occur if these drugs are taken together. Intravenous use of Growpone should be avoided in patients receiving cardiac glycosides. If absolutely necessary, Growpone should be taken slowly in small amounts; Tetracycline: Calcium forms complexes with tetracycline antibiotics, rendering them inactive. Therefore, do not mix Growpone with Tetracycline before injection; Vitamin D : Avoid high doses of vitamin D during treatment with Growpone unless specifically indicated; Use of Growpone may reduce the response to Verapamil and perhaps to other calcium channel blockers. The article has provided information about uses, dosage and precautions when using Growpone. To ensure safety for your health and maximize the effectiveness of your treatment, you need to use Growpone exactly as directed by your doctor.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.