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The drug Godartem has the main ingredients Artemether and Lumefantrin, commonly used in the treatment of malaria. When using Godartem, patients may experience some unwanted effects such as headache, dizziness, loss of appetite, abdominal pain.
1. What is Godartem?
Godartem is a prescription drug in the treatment of malaria, the main active ingredients of which are Artemether and Lumefantrin.
Dosage form: tablets. Each tablet contains 80mg Artemether, 480mg Lumefantrin and excipients just enough for 1 tablet.
Packing form: box of 1 blister x 6 tablets
2. Uses of Godartem
Artemether and Lumefantrin both have the effect of killing the schizonts of the malaria parasite in red blood cells. The mechanism of action of these two substances is to prevent the conversion of heme to non-toxic hemozin (hem is a toxic intermediate produced by hydrolysis of hemoglobin).
Inside the diseased red blood cells, the malaria parasite feeds on and degrades the hemoglobin, thereby releasing the iron in the toxic form of heme. Hem will concentrate in the digestive vacuoles of the malaria parasite. Then, the heme will be converted to non-toxic hemozin.
After oral administration, Artemether will distribute mainly in the digestive vacuoles of malaria parasites and interfere with the conversion of heme to hemozin, and destroy hemozin to release heme and free radicals. Besides, Lumefantrin affects the detoxification process of malaria parasites. Artemether and lumefantrin together inhibit the synthesis of nucleic acids and proteins of the malaria parasite, this combination has a rapid killing effect on the gametophyte.
3. Indications and contraindications of the drug Godartem
Godartem is usually indicated in the following cases:
Uncomplicated malaria caused by Plasmodium falciparum in patients with body weight over 35kg. Malaria in chloroquine resistant endemic areas. Contraindications: Absolutely do not use Godartem in the following cases:
Patients with hypersensitivity to any component of Godartem Adults and children with body weight under 35kg in the first 3 months of pregnancy
4. Dosage and how to use Godartem
In order for Godartem to promote its anti-malarial effect and avoid adverse effects, you need to follow your doctor's instructions, do not arbitrarily change the dose, route of administration or stop taking the drug when your condition improves. In addition, do not give Godartem to other people if they have the same symptoms as you.
Dosage:
Starting: 1 tablet, 8 hours after taking 1 tablet. After 24 hours: take 1 tablet After 36 hours: take 1 tablet After 48 hours: take 1 tablet After 60 hours: take 1 tablet A total of 6 tablets.
How to use: Should be taken with a high-fat meal or milk. Malaria patients often have anorexia, so it is necessary to encourage the patient to eat, because food helps to increase the absorption of Godartem. If the patient vomits within 1 hour of taking the drug, give the patient another dose.
What to do when you forget a dose of Godartem ?
Take another dose as soon as you remember, maybe 1-2 hours after the usual time. If it is almost time for your next dose, skip the missed dose and take your next dose as directed. Do not take a double dose to make up for a missed dose. What to do in case of an overdose of Godartem?
When overdose, patients may experience some symptoms such as cardiac abnormalities, arrhythmias, central nervous system disorders. It is necessary to bring the patient to the nearest medical facility for timely emergency treatment, and bring all the medication that the patient has taken. Treatment of Godartem drug poisoning includes symptomatic treatment and supportive treatment, possibly using activated charcoal to reduce the amount of drug absorbed into the blood. In addition, it is necessary to monitor the patient's electrocardiogram and blood potassium levels.
5. Undesirable effects of Godartem?
In addition to the therapeutic effects that Godartem brings, you may also experience adverse effects such as:
Common: dizziness, dizziness, headache, insomnia, digestive disorders, cough, tachycardia, musculoskeletal pain, rash, pruritus, fatigue, weakness, ... Frequency unknown: somnolence, involuntary muscle contractions, sensory disturbances, abnormal gait, ataxia Rare: Hypersensitivity Inform the doctor when there are unusual symptoms during the use of the drug.
6. Godartem drug interactions?
When treating many different drugs, it may cause synergism or competition between drugs and affect drug absorption. Therefore, it is necessary to inform the doctor about all the drugs you are taking to avoid drug interactions. Drugs that can interact with Godartem drugs such as:
Mefloquine Quinine Halofantrin Tranquilizers Tricyclic antidepressants
7. Some notes when using Godartem
Using Godartem for pregnant women: Contraindicated to use Godartem in the first trimester of pregnancy. During the next 6 months, the drug is used only when the benefit to the mother outweighs the harm to the fetus.
Do not use Godartem for driving, operating machinery, working at height because this medicine can cause dizziness, insomnia, ...
Using Godartem on breastfeeding women: wait at least 28 the day after taking the new medicine, breastfeed the baby.
Be careful when using Godartem for the following subjects: patients with impaired liver and kidney function, unable to eat or drink.
Above is important information about the drug Godartem, before using it, patients need to carefully read the instructions for use and follow the doctor's instructions to achieve the best treatment results.
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