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The drug Glomoti or Glomoti-M has the main ingredient Domperidon Maleat, which is commonly used in the treatment of digestive disorders. Learning the information related to the use, dosage, side effects of Glomoti drug will give patients the best treatment effect.1. What is Glomoti?
Glomoti -M is prepared in the form of 10mg/tablet film-coated tablets, with the main ingredients including:
Active ingredient: Domperidone maleate 12.73 mg (equivalent to Domperidon 10mg) Excipients: Microcrystalline cellulose , Lactose monohydrate, Pregelatinized starch, Magnesium stearate, Sodium starch glycolate, Opadry white. Just enough for 1 10 mg tablet. Active ingredient Domperidone has anti-dopamine properties, similar to Metoclopramide hydrochloride. Domperidone has no effect on the psyche and nervous system, so there is almost no mechanism of action on dopamine receptors in the brain.
In addition, Domperidone also has the effect of stimulating peristalsis in the gastrointestinal tract, helping to increase the tone of the cardiac sphincter, and at the same time increase the expansion amplitude of the pyloric sphincter after meals. However, this active ingredient does not affect gastric secretion.
2. What are the effects of Glomoti?
Glomoti-M is indicated for the treatment of the following cases:
General case: Digestive disorders such as nausea, vomiting, bloating, indigestion, heartburn, belching a lot, anorexia. Adults: Support treatment of esophageal reflux, treatment of signs after gastric bypass surgery. People with chronic gastritis or gastric prolapse. Children: Treat children with periodic vomiting, support treatment of children with upper respiratory infections or are using cancer drugs. Glomoti-M is effective in reducing the symptoms of acute nausea and vomiting, both nausea and vomiting, caused by the use of levodopa or bromocriptin in people with Parkinson's disease.
3. Contraindications to the use of Glomoti-M:
Hypersensitivity to any ingredient of the drug. History of allergy to drugs containing domperidone. Children < 1 year old. People with pituitary tumors secrete the hormone prolactin. People with gastrointestinal bleeding. People with intestinal obstruction due to mechanical causes. Do not use for people with gastrointestinal perforation. Do not use in patients with symptoms of vomiting after surgery. Take the medicine regularly and for several days.
4. Dosage and usage of Glomoti-M:
4.1. Dosage: Adults or children ≥ 12 years old (or ≥ 35kg):
Dose: Take 1-2 tablets (10-20 mg)/time every 4-8 hours. Take no more than 8 tablets (80mg) a day. For children 5-12 years old:
Dose: Take 1⁄2 - 1 tablet (5-10 mg)/time every 4-8 hours. Take no more than 4 tablets (40mg) a day. Use for children 1-5 years old:
Dose: Oral 0.2 - 0.4 mg/kg/time every 4-8 hours. 4.2. How to use Take the medicine 15-30 minutes before meals. Swallow the tablet whole, do not crush or break the pill. It is recommended that treatment with Glomoti-M not exceed 3 months.
5. Glomoti-M side effects
High dose or prolonged treatment with Glomoti-M, especially in children, can cause side effects such as:
Common: Dry mouth. Uncommon: Neuropsychiatric disorders such as anxiety, agitation, nervousness. Drowsiness, headache. Diarrhea, itching, urticaria, rash, breast pain, abnormal lactation, breast tenderness. Asthenia, decreased or lost libido, extrapyramidal disorders. Frequency not known: Hypersensitivity, severe allergic reactions may cause anaphylaxis. Convulsions, dyskinesia. Cardiac arrhythmias such as ventricular arrhythmias, QT prolongation, torsades de pointes, and sudden cardiac death in patients over 60 years of age. Angioedema, urinary retention, amenorrhea, breast enlargement in men. Hyperprolactinemia, abnormal liver function. Currently, there is no specific antidote for the active ingredient Domperidone. In the event of undesirable effects, the drug should be discontinued immediately. At the same time, report the situation to the doctor and immediately go to the nearest medical examination and treatment facility for timely treatment.
6. Use caution when using drugs in subjects
Caution when using Glomoti-M in the following cases: People with Parkinson's disease because the active ingredient Domperidone can have harmful effects on the nervous system. Do not treat people for more than 12 weeks with Parkinson's or consider safer antiemetics. Patients with impaired liver or kidney function should be reduced dose by 30-50% and divided into several times a day. Patients with cardiovascular disease such as congestive heart failure, disturbances of cardiac impulse conduction. People with electrolyte disturbances such as hypokalemia or marked hypomagnesaemia Pregnant or lactating women: Currently, there are no accurate data to assess the potential for complications in pregnancy, so its use should be limited. pregnant women. The active ingredient Domperidone in Glomoti-M can be excreted in breast milk in low concentrations. Do not breastfeed while using Glomoti-M. Drivers or workers who operate machinery are unlikely to have little or no effect with Glomoti-M.
7. Glomoti-M drug interactions:
The active ingredient Domperidone in Glomoti-M is inhibited by drugs with anticholinergic effects. CYP3A4 Inhibitors: Erythromycin, Ketoconazole, or Ritonavir increase blood levels of the active ingredient Domperidone. At the same time, the simultaneous use of these two drugs may cause cardiac arrhythmias with manifestations of QT interval prolongation. In addition to Paracetamol and Digoxin, Glomoti-M may reduce the absorption of other medicinal products when taken together. The class of drugs that inhibit acid secretion or antacids reduce the bioavailability of Glomoti-M. Do not take these drugs concurrently with Glomoti-M. The above is general information and notes when using Glomoti-M. In order to achieve the best treatment results, patients should carefully read the instructions for use and strictly follow the instructions of the doctor.
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