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Fenilham is an opioid analgesic, commonly indicated for pain relief in oncology, surgical anesthesia and postoperative analgesia. The drug is 100 times stronger than Morphine. Follow the article below to know what Fenilham drug works?1. What is Fenilham?
Fenilham has the main ingredient is Fentanyl - belongs to the group of opioid pain relievers. Fenilham acts through the mechanism of action of the μ-opioid receptor, inducing sleep-type pain relief, sedative effects at low doses, and sedating effects at high doses. The drug acts quickly after injection from 3-5 minutes and the effect lasts 1-2 hours. Fenilham is rapidly absorbed after injection, reaching peak plasma concentrations. The effectiveness of pain relief and the effect of the drug depends on the concentration and tolerability of the individual.
2. Indications of the drug Fenilham
Fenilham is indicated in the following cases:
Pain relief in cases where strong opioid pain relief is required such as cancer and major fractures,... Pain relief during and after surgery requires a ventilator to assist. Assist in preoperative anesthesia and mechanical ventilation during resuscitation. In combination with local anesthetics in epidural and spinal anesthesia.
3. Contraindications of the drug Fenilham
Fenilham is contraindicated in cases of allergy to fentanyl or any other ingredient of the drug.
Note when using Fenilham:
Do not use Fenilham in acute pain management and after surgery because the dose is unpredictable and can cause severe respiratory depression. Monitor patients closely while taking this drug because of the possible risk of respiratory depression due to the effects of Fenilham on the central nervous system. Patients with chronic obstructive pulmonary disease taking opioids may experience decreased breathing and increased resistance to ventilation. Continuous, prolonged use of Fenilham may cause decreased tolerance and dependence. Patients with brain tumors taking drugs may increase intracranial pressure. Fenilham slows the heart rate in patients with a history of bradycardia. Monitor liver function before and during administration due to hepatotoxicity of Fenilham. Fenilham may affect the ability to concentrate, mind and body. Fenilham should be avoided in patients who require meticulous work, driving, operating machinery, etc. The safety of Fenilham for fetuses and children has not been fully studied. Therefore, pregnant and lactating women should not use the drug. Elderly patients should consider reducing the dose of Fenilham due to the potential for liver and kidney toxicity.
4. Fenilham drug interactions
Concomitant use of Fenilham with drugs that depress the central nervous system (anxiety reliever, sedative, muscle relaxant, hypnotic antihistamine) may increase the inhibitory effect. Concomitant use of Fenilham with hepatic CYP3A4 inhibitors (ritonavir) may increase drug concentrations and prolong its effectiveness, causing respiratory depression.
5. Dosage and usage
How to use:
Fenilham is prepared as a solution for intravenous injection. Use of the drug must be prescribed and monitored by a specialist.
Dosage in adults:
Pre-anesthesia in adults: 50-100 micrograms/time. Slow intravenous injection. Anesthesia support (patients breathing on their own): Initial intravenous dose of 50-200 micrograms. Then inject 50 micrograms after 30 minutes depending on response. Anesthesia support (patients with respiratory support): Initial dose 300 – 3500 micrograms. Then inject 100-200 micrograms after 30 minutes depending on response. The maximum dose is 50 micrograms/kg. Epidural anesthesia in combination with local anesthetic Bupivacaine: 50-100 micrograms/time. Spinal anesthesia: 25-50 micrograms/time. Postoperative analgesia: Slow intravenous infusion of 50-200 micrograms/hour or use of an electric syringe. Dosage in children from 2 to 12 years old:
Pre-anesthesia: 3-5 micrograms/kg/time. Slow intravenous injection. Analgesia, sedation: The starting dose is 15 micrograms/kg. Then 1-3 micrograms/kg after 30 minutes depending on response. Postoperative analgesia: Initial dose of 3-5 micrograms/kg by slow intravenous injection or by use of an electric syringe; then inject 1 microgram/kg/time.
6. Fenilham side effects
When using Fenilham, patients may experience some unwanted effects as follows:
Anaphylactic reactions. Allergic reactions at injection site: pruritus, erythema,... Hypoventilation and respiratory depression. Nausea, vomiting, constipation and diarrhea. Lower blood pressure and slow heart rate. Headache, drowsiness, hallucinations and anxiety. Increased sweating. Secret urine. In summary, Fenilham is a powerful analgesic, indicated in chronic pain, to support pain relief during and after surgery and to support anesthesia. The drug must be prescribed by a specialist and the patient's condition should be closely monitored throughout the treatment period.
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