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Fawagy drug has the main active ingredient Metronidazole 250mg and other excipients in sufficient quantity. This is an antibiotic of the Nitro-5 family Imidazole has the effect of treating parasites, anti-infectives, antivirals and antifungals.
1. What is Fawagy?
The main active ingredient Metronidazole in Fawagy is an antibacterial drug of the nitro-5 imidazole family.Ability to absorb: After oral administration, drug Metronidazole is rapidly absorbed, at least 80% after 1 hour. With equivalent doses, the same serum concentrations are achieved following oral and parenteral administration. Oral bioavailability is 100% and is not affected by food. Distribution: Approximately 1 hour after oral administration of 500 mg, maximum serum concentrations average 10 mcg/mL. The mean serum half-life is 8 to 10 hours. This active substance has the ability to diffuse rapidly and strongly, with concentrations in lungs, kidneys, liver, bile, cerebrospinal fluid, saliva, semen, vaginal secretions equivalent to serum concentrations. Metronidazole active ingredient crosses the placental barrier and through breast milk. Biotransformation: The main active ingredient Metronidazole is metabolized mainly in the liver, oxidized to give 2 main metabolites: Alcohol metabolite, which is the main metabolite, has the effect of killing anaerobic bacteria. about 30% compared with metronidazole), half-life: 11 hours. Acid metabolite, about 5% bactericidal effect compared to metronidazole. Excretion: High concentrations in liver and bile, low in colon. This active substance is rarely excreted in the feces. Excretion is mainly in the urine because metronidazole and its oxidised metabolites are present in the urine from 35 to 65% of the dose. Drug substance Metronidazole has good effect on both amoeba in and outside the intestine, both acute and chronic. In the treatment of chronic intestinal amoebic dysentery, the drug has a weaker effect due to less penetration into the colon. Metronidazol also works well with Trichomanas vaginalis, Giardia, gram-negative anaerobes including Bacteroides, Clostridium, Helicobacter but has no effect on aerobic bacteria. The mechanism of action of metronidazole is as follows: The nitro group of metronidazole is reduced by electron transport proteins or by ferredoxin. The reduced form of metronidazole destroys the helix structure of DNA, killing bacteria and protozoa.
2. What are the effects of Fawagy?
Fawagy drug is used in the treatment of the following diseases:
Treatment of urinary tract infection - genital tract for both men and women. Treatment of Giardia lambia and amebic infections. Treatment of mouth ulcers. Prophylactic treatment of infections caused by anaerobic bacteria. Prophylactic treatment after gastrointestinal surgery and gynecological surgery.
3. Usage and dosage of Fawagy
3.1. Usage of drug Fawagy Fawagy drug is prepared in the form of tablets, suitable for direct oral use. The time to take the medicine is to take it during or after a meal with a little water. 3.2. Dosage of Fawagy Drug Dosage for treatment of anaerobic infections 7 days: For adults: oral dose of 30-40 mg/kg/day, divided into 4 times; for children: 20 - 30mg/kg/day, divided into 4 times. Duration of dose used to treat intestinal amoebic dysentery is from 7 to 10 days; duration of treatment for liver amoeba is 5 days; for adults: 1.5 g - 2 g/day, divided into 4 times a day; for children: 40 - 50 mg/kg/day, divided into 4 times a day. Dosage for treatment of Trichomoniasis in the genital tract is 250mg, 3 times a day (for women and men) for 7 days, for women, it can be combined with vaginal placement. Dosage for treatment of Giardia infection is 2 g daily, divided into 4 times, the duration of treatment is 3 days.
4. Undesirable effects of drug Fawagy
In the process of using Fawagy drugs rarely encounter unwanted effects. However, occasionally reported adverse effects such as mild gastrointestinal disturbances: nausea, anorexia, metallic taste in the mouth, burning pain in the epigastrium, vomiting, diarrhea.
Some other undesirable effects of unknown frequency may occur when using the drug, including:
Skin and mucosal reactions: urticaria, vasomotor flushing, itching, glossitis with a burning sensation in the mouth; Neurological and psychiatric signs: headache, dizziness, confusion, convulsions; Pancreatitis, reversible upon discontinuation of treatment with this drug. Decrease in white blood cell count. Peripheral sensory neuropathy, these signs and symptoms always decrease and then completely disappear when treatment is stopped. Urine may be red-brown due to pigments formed during drug metabolism.
5. Fawagy drug interactions
Fawagy should not be combined with the following drugs:
Disulfiram: Because it can cause paranoia and psychosis. Alcohol: Antabuse effect with signs including heat, redness, vomiting, heart palpitations. Caution should be exercised when combining Fawagy with oral anticoagulants. Specifically, Warfarin: increases the effect of anticoagulants and increases the risk of bleeding (caused by decreased metabolism in the liver). The treating physician will adjust the dose of anticoagulants during treatment with metronidazole-containing drugs up to 8 days after stopping treatment.
Other Fawagy combinations should also be noted:: Using Fawagy with 5 Fluoro-uracil: increased toxicity of 5 Fluoro-uracil due to decreased clearance.
Laboratory tests: The active ingredient Metronidazole can immobilize spirochetes, thereby distorting the results of Nelson's test.
6. Some notes when using Flametro
6.1. Contraindications of Fawagy People who are sensitive or hypersensitive to the main active ingredient Metronidazole or other ingredients in the drug. People who have or have a history of epilepsy. People with blood clotting disorders. The woman is in the first 3 months of pregnancy, breastfeeding. 6.2. Other notes and precautions when using Fawagy Monitor white blood cell counts for people taking high doses or taking this drug for a long time. In case of leukopenia, continued treatment depends on the severity of the infection. Use in pregnancy: According to animal studies, metronidazole is not teratogenic and is not embryotoxic. The study was conducted on hundreds of pregnant women using the active ingredient Metronidazole during the first 3 months of pregnancy, there were no cases of malformations; and studies used after this period of 3 months did not find toxicity to the embryo. Therefore, the active ingredient Metronidazole is not contraindicated in pregnant women in case of necessity. Use in women who are breastfeeding: Avoid using medicines containing the active ingredient Metronidazole while you are breastfeeding. This is because metronidazole can be excreted in breast milk. Fawagy should be stored at room temperature, away from direct sunlight. Above is all information about Fawagy drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Fawagy medicine to treat diseases at home, because there may be unwanted side effects on health.
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