Uses of Sotramezol

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1. What are the effects of Sotramezol?

Each Sotramezol tablet contains 400mg Metronidazole as the main ingredient. Metronidazole is an antibacterial drug belonging to the nitro-5 imidazole family. Metronidazole has good effects on both the external and internal amoeba, both chronic and acute. With chronic intestinal amoebic dysentery, Sotramezil has a weaker effect due to less penetration into the colon. The drug also works well against Giardia, Trichomonas vaginalis and gram-negative anaerobic bacteria including Helicobacter, Bacteroides, Clostridium but has no effect on aerobic bacteria. The mechanism of action of Metronidazole is: The nitro group of Metronidazole is reduced by the electron transport protein or by the ferredoxin protein. Metronidazole in its reduced form causes the loss of the helical structure of DNA, and is capable of killing bacteria and protozoa.
Use Sotramezol in the following cases:
People infected with Trichomonas urinary tract - genitals in both women and men; Patients with amoeba and Giardia lambia infections; People with mouth ulcers ; Prevention of infections caused by anaerobic bacteria; Prevention after gynecological and gastrointestinal surgery. Do not use Sotramezol in the following cases:
Patients with blood clotting disorders; Women who are in the first 3 months of pregnancy; women who are breastfeeding; Hypersensitivity to any ingredient in Sotramezol.

2. How to use and dose of Sotramezol

2.1. How to use Use Sotramezol by drinking directly with filtered water, should take the whole pill; Do not take Sotramezol with milk or fruit juice without consulting your doctor. These drinks can reduce the absorption of the drug and thereby reduce the effectiveness of treatment; In addition, patients should be careful not to crush or break the drug when taking it. This can increase metabolism, making the drug more active and causing unwanted effects. 2.2. Dosage Usual dose in the treatment of amoebiasis: Adults: Use 1500mg/day, divided into 3 oral doses; Children: Use 30-40 mg/kg/day, divided into 3 oral doses; Duration of treatment: 1 week; Usual dose when treating diseases caused by Trichomonas: Vaginitis: Use 2000mg/day, take only 1 dose. Or can use 500mg/day, divided into 2 oral doses and treat within 10 days; Urethritis: Use 2000mg/day, take only 1 dose. Or you can take 500mg/day divided into 2 oral doses and treat within 10 days; Usual dose in the treatment of Giardia intestinalis: Adults: Use 750 - 1000mg/day, divided into 3 equal doses; Children: From 2 to 5 years old use 250mg/day; from 5 to 10 years old use 375mg/day and from 10 to 15 years old use 500mg/day; Treatment time: 5 days; Usual dose in the treatment of non-specific vaginitis: 500mg/time x 2 times/day; Duration of treatment: 1 week; Usual dose when treating infections caused by anaerobic bacteria: Adults: 1000 - 1500mg/day, divided into 03 doses; Children: 20 - 30mg/kg/day; Note: If you find that the usual dose of Sotramezol does not meet the symptoms, the patient should talk to a specialist doctor for a dose adjustment.
2.3. Missing dose and overdose Using underdose of the drug Sotramezol significantly affects the activity of the drug. This condition can cause the drug to decrease the mechanism of action, leading to not completely treating the disease symptoms; If you forget to take a dose of Sotramezol, take it as soon as you remember. In case it is almost time for the next dose, skip the missed dose and take the next dose as scheduled; An overdose of Sotramezol can cause dangerous symptoms. Patients should proactively notify their doctor if they find themselves using more than the recommended dose.

3. Sotramezol side effects

During the use of Sotramezol, patients may experience some undesirable effects:
Common side effects: Epigastric pain, nausea, anorexia, taste changes, diarrhea, vomiting; Uncommon side effects: Glossitis, urticaria, itching, dry mouth, convulsions, dizziness, confusion, headache, peripheral nerve pain, leukopenia, red-brown urine. Sotramezol causes adverse effects during use. When these symptoms arise, it is important to notify your doctor for prompt treatment. Patients should notify the doctor for timely diagnosis and treatment instructions, note that do not arbitrarily use other drugs to treat side effects of Sotramezol.
Common side effects tend to go away on their own after a few days or weeks. Meanwhile, serious reactions can develop and threaten the health of the user. With serious side effects, the doctor may order treatment to improve the situation.

4. Be careful when using Sotramezol

Some notes patients need to remember before and while taking Sotramezol are:
Consult your doctor before using Sotramezol for pregnant women and women who are breastfeeding. Arbitrary use of drugs can cause birth defects or cause unwanted symptoms in young children; It is necessary to reduce the dose of Sotramezol in patients with cirrhosis, alcoholism or severe renal dysfunction; Keep taking Sotramezol even if your symptoms have disappeared. Stop taking the drug only when directed by a specialist. Stopping the medication suddenly can cause the fungus to grow and cause the disease to return.

5. Sotramezol drug interactions;

Sotramezol may interact with some of the following drugs and drinks:
Concurrent use of Sotramezol with disulfiram may cause paranoia and psychosis; Alcohol and alcoholic beverages when taken concurrently with Sotramezol may give rise to antabuse effects (such as heat, redness, tachycardia and vomiting); The anticoagulant warfarin when used concurrently with Sotramezol may increase the risk of bleeding; Sotramezol reduces the extent of elimination and increases the toxicity of 5-Fluorouracil; The above information does not include all drugs that have the potential to interact with Sotramezol. Therefore, patients need to actively inform their doctors about the drugs they are taking so that they can consider drug interactions and make reasonable adjustments. During the treatment of Sotramezol, patients should pay attention to follow the doctor's instructions to achieve high treatment efficiency and limit unwanted side effects.

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