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Ezenstatin drug with main ingredients Atorvastatin and Ezetimibe is effective in preventing cardiovascular events in patients with coronary artery disease with a history of acute coronary syndrome and treating hypercholesterolemia. However, because it is a group of cardiovascular drugs, patients also need to take some precautions when using it to avoid unfortunate complications.1. What is Ezenstatin drug?
Ezenstatin 10/20mg drug has the main ingredients including 10mg Ezetimibe and 20mg Atorvastatin 20mg (in the form of Atorvastatin calcium) which inhibit the absorption and synthesis of cholesterol, specifically as follows:
Ezetimibe: localized at the table border brushing the small intestine and inhibiting cholesterol absorption leads to a decrease in cholesterol transport from the intestine to the liver, thereby reducing cholesterol storage in the liver and increasing cholesterol clearance from the blood, this separate mechanism will complement the effect of cholesterol in the liver. of statins Atorvastatin: is a competitive inhibitor of HMG-CoA reductase, prevents conversion to mevalovat, a precursor of cholesterol, thereby inhibiting cholesterol biosynthesis, lowering cholesterol in hepatocytes, stimulating receptor synthesis LDL body and thereby increase the transport of LDL from the blood. As a result, blood cholesterol decreased. Atorvastatin was the strongest LDL cholesterol reducer compared with other statins alone
2. When is Ezenstatin indicated?
Ezenstatin is indicated in the treatment of the following cases:
Prevention of cardiovascular events in coronary artery disease with a history of acute coronary syndrome previously treated with or without statin therapy Treatment of hypertension blood pressure in people with metabolic complications such as diabetes Hypercholesterolemia: drugs to reduce total cholesterol, low-molecular-weight cholesterol, and high-molecular-weight cholesterol are indicated as adjunctive therapy for Diet in patients with primary hypercholesterolemia (heterozygous familial and non-familial) or mixed dyslipidemia when the patient is not adequately controlled on statin alone or patients treated with statins and ezetimibe separately Homozygous familial hypercholesterolemia or in addition to other lipid-lowering treatments Contraindications to Ezenstatin include:
Patients with known hypersensitivity to atorvastatin, ezetimibe or any excipients of the drug Patients with active liver disease or unexplained persistent elevations in serum transaminases Pregnant or lactating women
3. How to use Ezenstatin?
Patients next to taking medicine need to maintain a standard, low-cholesterol diet. A single dose can be taken at any time of the day, with a meal or on an empty stomach. Since cholesterol synthesis in the liver occurs mainly at night, taking the drug in the evening will increase its potency. When taking the drug should be swallowed whole, do not crush or dissolve, chew the medicine.
The recommended starting dose is the lowest dose at which the drug is effective. Thereafter, if necessary, the dose can be adjusted in intervals of not less than 4 weeks until the desired LDL cholesterol concentration is reached. The recommended dose is as follows:
Initial dose: 10/10mg/day or 10/20mg/day, check after 2 weeks Maintenance dose: 1 tablet 10/10mg-10/20mg/day if necessary, increase dose but no more than 80 mg/day
4. Ezenstatin drug side effects
In general, Ezenstatin is well tolerated and requires less discontinuation than other drugs. Some common side effects include:
Digestive: diarrhea, constipation, flatulence, abdominal pain and nausea Nervous: headache, dizziness, blurred vision, insomnia, weakness Muscle and joint pain Uncommon more may have neuromuscular disease, skin rash, rhinitis, sinusitis Most rarely myositis reactions, rhabdomyolysis, cognitive impairment, increased fasting serum glucose with risk of developing diabetes
5. Some notes when taking Ezenstatin
When using the drug, caution should be taken in the following cases:
Consider using the drug for patients with risk factors for muscle damage such as patients over 65 years old, hypothyroidism, kidney disease. Before taking the drug, it is necessary to rule out the causes of hypercholesterolemia such as: poorly controlled diabetes, hypothyroidism, nephrotic syndrome, alcoholism. dose response to patient's medication Use LDL cholesterol as the goal of treatment instead of total cholesterol Control blood cholesterol with appropriate diet, exercise, and weight loss in obese patients Do liver enzyme tests before starting statin therapy Consider monitoring creatine kinase (CK) Use only in women of childbearing age when it is certain they are not pregnant and only in very high blood cholesterol. This medicine contains lactose, so patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Above is important information about Ezenstatin drug. Before using, patients should carefully read the instructions for use and consult a specialist to use the drug more effectively.
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