This is an automatically translated article.
Ezensimva is a drug for the treatment of primary or mixed hyperlipidemia (uncontrolled with statin monotherapy or with statin and ezetimibe treatment separately). Although there are relatively few side effects, users of Ezensimva still need to know some characteristics of the drug to use the drug effectively.
1. Effects of Ezensimva
Ezensimva medicine has the main ingredients ezetimibe and simvastatin which work to lower bad cholesterol and fats such as LDL, triglycerides and increase good cholesterol (HDL) in the blood thereby reducing the risk of heart disease and helping to prevent stroke, pain heart , specifically as follows:
Ezetimibe works by reducing the amount of cholesterol the body absorbs from the diet thereby lowering blood cholesterol. Simvastatin is synthesized from a fermentation product of Aspergillus terreus that inhibits HMG-CoA reductase, thereby reducing low-density lipoprotein (LDL) cholesterol levels. Thanks to the above active ingredients, Ezensimva is commonly prescribed in the following cases:
Treatment of primary hypercholesterolemia or mixed hyperlipidemia. The patient is not adequately controlled on statin alone. The patient was treated with statins and ezetimibe separately.
2. How to use Ezensimva?
While using the drug and after finishing treatment with Ezensimva, the patient should adhere to a low cholesterol diet. Take the drug only once in the evening, can be taken with or without food. The drug is not for children, only used for adults with the following reference doses:
The starting dose is the lowest dose that the drug has an effect, then the dose can be adjusted according to the patient's response to each adjustment. less than 4 weeks until desired LDL cholesterol level or maximum dose is reached. Recommended starting dose is 10/10 mg/day or 10/20 mg/day Patients with hepatic impairment do not require dose adjustment with hepatic impairment Patients with renal impairment do not require dose adjustment if renal disease is mild or moderate with creatinine clearance < 60 ml/min. If drug therapy is required in patients with severe renal impairment (creatinine clearance <30ml/min), close monitoring is required if doses higher than 10/10mg/day are used Elderly patients do not require dose adjustment Patients receiving verapamil , diltiazem, dronedarone: dose of Ezensimva should not exceed 1 tablet/day. Patients taking amiodarone, amlodipine, ranolazine should not exceed 1 tablet of Ezensimva/day.
3. Contraindications and side effects of Ezensimva
Contraindications to the use of Ezensimva in the following cases:
Patients with hypersensitivity to simvastatin, ezetimibe or any of the excipients of the drug Patients with active liver disease or persistent elevations in serum transaminases that do not resolve Suitable for pregnant or lactating women Do not take the drug in combination with strong CYP3A4 inhibitors such as: Itraconazole, ketoconazole, erythromycin, clarithromycin,... In addition, during the use of Ezensimva, the patient may Some of the side effects are as follows:
Unexplained muscle pain, pain or weakness Memory problems, confusion Fever, unusual tiredness, dark urine Burning pain when urinating Swelling, increased weight, little or no urinating Thirsty, frequent urination, hunger, dry mouth, fruity breath, drowsiness, dry skin, blurred vision, weight loss Nausea, upper abdominal pain, itching, loss of appetite, colored stools clay, jaundice Less serious side effects may include headache, joint pain, mild muscle pain, constipation or indigestion, mild rash, insomnia, sneezing steam, stuffy nose.
4. Drug interactions with Ezensimva
Long-term treatment with Ezensimva may increase the risk of myopathy, therefore caution should be taken when co-administering drugs with the following interactions:
Inhibitors of cytochrome CYP3A4: avoid this combination therapy. with cyclosporin, erythromycin, gemfibrozil with niacin at lipid-lowering doses (>1g/day), with colchicine and other fibrate-lowering agents, because of possible myositis, rhabdomyolysis. Coumarin Derivatives: Simvastatin may potentiate the effects of warfarin, determine prothrombin time before initiating this drug and monitor it frequently during the early stages of treatment to ensure there is no significant change in prothrombin time. Bile acid binding resins: Simvastatin and bile acid binding resins such as cholestyramine, colestipol have complementary mechanisms of action. Therefore, it is necessary to combine this group of drugs with synergistic effects on LDL cholesterol. However, this class of drugs can significantly reduce the bioavailability of simvastatin when taken together, so the time between these two drugs should be about 2 hours apart to avoid drug interactions. Ezensimva is a drug for the treatment of primary or mixed hyperlipidemia (uncontrolled with statin monotherapy or with statin and ezetimibe therapy separately). To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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