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What is Esomeptab 40mg, what are the uses of Esomeptab 40mg, how to use it and how to use it, what to pay attention to when using? Here is all the information about Esomeptab 40mg that everyone needs to know. From there, use the drug to ensure safety, in the right way to achieve the best effect when prescribed.1. What is Esomeptab 40mg?
Esomeptab 40mg is a pharmaceutical product manufactured by Quang Binh Pharmaceutical Joint Stock Company - Vietnam.
Esomeptab 40mg drug belongs to the category of antacids, anti-reflux and ulcer drugs. The drug contains the active ingredient Esomeprazole 40mg, which works to prevent and treat gastro-oesophageal reflux disease, peptic ulcer disease, severe gastric-duodenal bleeding,...
The drug is made in the form of tablets. compressed film-coated and packed in a box of 3 blisters x 10 tablets.
2. Uses of Esomeptab 40mg
Esomeprazole is a proton pump inhibitor that reduces gastric acid secretion by inhibiting a specific enzyme in the parietal cells of the stomach. Esomeprazole is the S-isomer of omeprazole, converted by protons to an active inhibitor in the acidic environment of the parietal cells of the stomach, the free form of sulphenamide. Therefore, Esomeprazole will block the final step in acid production, thereby reducing stomach acid levels. With the above effects, Esomeptab 40mg is used to appoint for the following cases:Adults:
Patients with peptic ulcer disease. Prevention and treatment of gastric ulcer, duodenal ulcer caused by taking NSAIDs (non-steroidal anti-inflammatory drugs). Prevention and treatment of peptic ulcers caused by stress. Treatment of gastroesophageal reflux - esophagus. Zollinger-Ellison syndrome. Hemorrhage due to severe peptic ulcer. In combination with an appropriate antibacterial regimen in the treatment of duodenal ulcer disease caused by Helicobacter pylori. Children over 12 years old:
Treatment of gastroesophageal reflux disease - oesophagitis. In combination with antibiotics in the treatment of duodenal ulcers caused by Helicobacter pylori.
3. Contraindications to Esomeptab 40mg
Esomeptab 40mg is contraindicated in the following cases:
Patients with hypersensitivity to Esomeprazole or Benzimidazole derivatives or any of the ingredients in the drug. Do not combine drugs with Nelfinavir and Atazanavir. Patients with hypersensitivity to proton pump inhibitors. Children under 12 years old.
4. How to use, dose of Esomeptab 40mg
Uses Esomeptab 40mg will be fully effective if used correctly and at the right dose. Therefore, users should follow the doctor's prescription or can refer to the usage and dosage below:
How to use:
Esomeptab 40mg is made in tablet form, should be taken orally before eating a small amount of food. least 1 hour. The drug should be swallowed whole with cooled boiled water, should not be broken, crushed or chewed as this may reduce the effectiveness of the drug. Dosage in adults:
Gastro-esophageal reflux syndrome: The starting dose is 40mg/day, which can last 4 to 8 weeks for patients who have not recovered. Peptic ulcer disease caused by non-steroidal anti-inflammatory drugs: The required dose is 40mg x 1 time/day and used for 4-8 weeks. Treatment of Zollinger - Ellison syndrome: The starting dose is 40mg, twice a day. Then adjust the dose according to the patient's response, continue treatment as prescribed by the doctor. Treatment of gastric and duodenal ulcers caused by Helicobacter pylori infection: 40mg/day for 10 days. Dosage for other subjects:
Children 12 years and older: The dose can be used as adults. Patients with renal impairment: No dose reduction is required, but if renal impairment is severe, caution should be exercised. Hepatic impairment: No dose reduction is required in mild and moderate patients, and in severe hepatic impairment, 20 mg/day may be considered. Note: The above dosage is for reference only, and the specific dose depends on the progress of the disease and the patient's condition. Therefore, to have the right dose, the patient should consult a doctor / pharmacist or medical professional.
5. Handling missed dose, overdose
If you forget to take a dose, take it as soon as you remember it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take a double dose of medicine to make up for a forgotten dose that will affect your health.
When taking Esomeptab doses as high as 280mg, symptoms related to the gastrointestinal tract and fatigue may appear.
There is currently no specific antidote to Esomeprazole. Therefore, when an overdose occurs, take the patient to the nearest medical unit for timely examination and treatment.
6. Side effects
The unwanted effects when taking Esomeptab 40mg that you may encounter are:
Common: Headache, abdominal pain, diarrhea, constipation, flatulence, nausea, vomiting. Uncommon: Peripheral edema, insomnia, somnolence, dizziness, dry mouth, elevated liver enzymes, urticaria, rash, pruritus, dermatitis. Rare: Leukopenia, thrombocytopenia, fever, angioedema, anaphylaxis, agitation, depression, hyponatremia, blurred vision, taste disturbances, bronchospasm, gastrointestinal candidiasis, inflammation liver, baldness, joint pain, muscle pain, increased sweating. Very rare: Temperament, hallucinations, pancytopenia, agranulocytosis, liver failure, muscle weakness, interstitial nephritis. Note: When experiencing unwanted side effects of the drug, the patient should stop using the drug and notify the doctor or go to the nearest medical unit for timely and effective treatment.
7. Drug interactions
Esomeptab 400mg will reduce absorption when co-administered with Ketoconazole and Itraconazole. In healthy subjects, when 40 mg of Esomeprazole was co-administered with cisapride, the AUC (area under the curve) was increased by 32% and the half-life of cisapride was prolonged by 31%, but peak plasma concentrations were not significantly increased. Esomeprazole inhibits CYP2C19, so when co-administering Esomeprazole with drugs metabolised by CYP2C19 such as Citalopram, Clomipramine, Diazepam, Imipramine, Phenytoin,... the concentration of these drugs in the blood plasma will increase. Esomeprazole has no clinically significant effects of Amoxicillin and Quinidine. Esomeprazole is metabolised by CYP2C19 and CYP3A4, therefore, co-administration of Esomeprazole with a CYP3A4 inhibitor, clarithromycin doubles the area under the curve (AUC) of Esomeprazole.
8. Attention and caution
In order for the use of Esomeptab 40mg to be effective in treating the disease, users need to be cautious:
Before taking proton pump inhibitors, it is necessary to exclude the possibility of stomach cancer because it can delay the diagnosis. cancer. Use with caution in people with liver disease, pregnant or lactating women. Prolonged use of esomeprazole may increase the risk of gastric infection or atrophic gastritis. Proton pump inhibitors may increase the risk of diarrhea. Proton pump inhibitors, especially in high doses and for many years, may increase the risk of fractures of the wrist, pelvis, or spine due to osteoporosis. Hypomagnesaemia is rare in patients on prolonged proton pump inhibitors.
9. How to store
Should store the medicine in a cool and dry place with a temperature below 30 degrees Celsius, not exposed to sunlight. Should not be stored in bathrooms, refrigerators and places with high humidity, it will easily cause the medicine to be damaged, watery... It is necessary to keep the medicine out of the reach of small children. Above is the information related to the drug Esomeptab 40mg. To ensure the safety of your health and maximize the effectiveness of treatment, you need to take the medicine exactly as directed by your doctor.
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