Uses of Enarena

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1. What is Enarenaline?

What is Enarenaline? Enarenal is a cardiovascular drug with the main ingredient Enalapril maleate 5mg and excipients croscarmellose sodium, sodium hydrocarbonate, lactose monohydrate and pregelatinized corn starch, and magnesium stearate. The drug is usually used for the treatment of essential hypertension or kidney disease, hypertension with diabetes...
Enarenaline 5mg is made in tablet form and packaged in a box of 3 blisters x 10 tablets.

2. Uses of Enarena 5mg

2.1 Effect of the main ingredient of the drug Enalapril contained in the drug Enarenal 5mg is an active ingredient that acts on the renin-angiotensin-aldosterone system by inhibiting ACE. Enalapril reduces peripheral arterial resistance and in heart failure Enalapril maleate reduces pre and afterload, cardiac output can be increased with little effect on heart rate.
Enalapril long-term treatment reduces hypertrophy and symptoms, as well as the degree of heart failure and increases exercise tolerance.
2.2 Indications With the effect of the active ingredient Enalapril maleate, Enalapril 5mg is usually used for indications in the following cases:
Hypertension: Enalapril is indicated for cases of hypertension of any degree, essential hypertension or hypertension due to kidney disease, hypertension with diabetes. Congestive heart failure: The drug is indicated for the treatment of symptomatic congestive heart failure, often in combination with diuretics and digital drugs. Asymptomatic left ventricular dysfunction: Drugs can prevent and reduce the rate of development of congestive heart failure, prevent ventricular dilatation after myocardial infarction. 2.3 Contraindications Enarenal 5mg drug is contraindicated in some of the following cases:
People with hypersensitivity to Enalapril or excipients of the drug, or hypersensitivity to ACE inhibitors ( ACE) other. Angioedema at the beginning of treatment (as with ACE inhibitors in general). Aortic stenosis and severe obstructive cardiomyopathy. Pre-existing hypotension. Renal artery stenosis (may cause acute renal failure). Children do not take the drug because there are no studies.

3. Usage – Dosage of Enarena 5mg

Uses of Enarenaline 5mg will promote the healing effect if used in the right dose, in the right way as prescribed by the treating doctor. Patients can refer to the method of use and dosage below:
How to use:
Enarenaline is made in the form of tablets, so it should be taken orally. When taking, the patient can split the pill but should not crush or break the pill, scattering the tablet may affect the effectiveness of the drug.
The drug should be taken with cooled boiled or purified water. Do not take the drug with beer, wine, coffee, carbonated drinks, fruit juice... will reduce the effect of the drug and may increase side effects.
Dosage:
Dosage is adjusted depending on the specific condition of each patient, the usual recommended dosage for adults is as follows:
Hypertension: Initial dose 2.5 - 5mg/1 time /day and the optimal dose is applied based on the patient's ability to respond. Congestive heart failure: Initial dose is 2.5 - 5 mg/day or may be divided into 2 doses depending on individual patient response. Asymptomatic left ventricular dysfunction: The starting dose is 5mg/day, divided into 2 doses in the morning and evening, the dose can be adjusted according to individual patient response. In case of renal failure: The starting dose should be reduced depending on the creatinine clearance such as: Creatinine clearance 30-80ml/min orally 5-10mg/day, and creatinine clearance from 10-29ml/minute orally 2.5- 5mg/day, creatinine clearance <10ml/min orally 2.5-5mg/day. Note: This is a reference dose, the dose may be changed according to the prescription of the treating doctor after assessing the patient's condition and ability to respond. Therefore, patients need to take the drug exactly as prescribed by the doctor to achieve the best treatment effect.

4. Side effects of Enarena 5mg

Enarenal 5mg drug may cause some side effects for patients during use such as:
Common, 4DR > 1/100: Headache, dizziness, insomnia, fatigue, paresthesia, asthenia, taste disturbance, diarrhea, abdominal pain, nausea and vomiting, angioedema, severe hypotension, syncope, palpitations and chest pain, rash, dry cough or possibly renal failure. Uncommon: 1/1000 < ADR < 1/100: Decreased hemoglobin and hematocrit, agranulocytosis, neutropenia, proteinuria, agitation, panic attacks, major depression. Rarely, ADR <1/1000: Intestinal obstruction, toxic cholestatic hepatitis, pancreatitis, oral mucosal sensitization. Other side effects: Hypersensitivity, blurred vision, depression, stuffy nose, myalgia, asthma and bronchospasm. If you experience one of the side effects of the above medicine or other unusual signs, immediately notify the treating doctor for advice or go to the nearest medical facility for instructions on timely treatment.

5. Enarenaline 5mg . drug interactions

Concomitant use of enalapril with certain other vasodilators or anesthetics may cause severe hypotension. Therefore, in this case, the patient should be closely monitored and corrected with intravenous fluids. Concomitant administration of enalapril with diuretics may result in excessive hypotension after initiation of enalapril therapy. When enalapril is used concurrently with drugs that cause renin release, the antihypertensive effect of enalapril is increased. Concomitant use with drugs that increase serum potassium may cause increased serum potassium, especially in individuals with renal impairment. Concomitant use of enalapril with lithium may increase serum lithium concentrations leading to lithium toxicity. Concomitant use of enalapril with non-steroidal anti-inflammatory drugs or sympathomimetic bronchodilators may reduce the antihypertensive effect of Enarenal. Concomitant use with oral contraceptives increases the risk of damaged blood vessels and uncontrolled blood pressure. Concomitant use of the drug with beta-adrenergic blocking drugs, methyldopa, calcium channel blockers, hydralazine, prazosin and digoxin did not show clinical side effects. Do not drink alcohol, beer and alcoholic beverages while taking the drug. In order to avoid drug interactions that adversely affect the effectiveness of Enarenaline and other drugs, the patient needs to inform the treating doctor about the drugs he is using (including prescription and non-prescription drugs). prescriptions, functional foods or herbs...) for the most appropriate advice and prescriptions.

6. Notes and cautions when using Enarenal 5mg

In order to ensure safety and help the use of Enarenaline to promote its full effect, patients need to be careful about the following issues:
Use the drug exactly as prescribed and prescribed by the treating doctor, do not change it on your own. Change the dose or stop taking the medicine suddenly, or stop the course of treatment without consulting your doctor. Before and during treatment with Enarena, renal function should be assessed. Caution should be exercised when administering the drug to patients with renal impairment and needing to reduce the dose or frequency of administration. For patients with suspected renal artery stenosis, serum creatinine should be measured prior to initiating treatment with Enarenal. Hypotension may occur after the first dose of Enalapril in patients with fluid loss due to diuretic therapy, dietary salt, diarrhea or vomiting. Severe hypotension may occur in patients with severe heart failure. Similarly, in patients receiving repeated high doses of diuretics, hyponatremia or renal failure may occur. Enalapril should be used with caution in patients with hepatic impairment. Enalapril can cause illness and death in an unborn baby, so pregnant women should not take it. The drug can also be excreted in breast milk, so pregnant women should not use it, only use it when absolutely necessary as prescribed by the doctor. Enalapril can cause dizziness, headache, fatigue, so do not use the drug while driving and operating machinery.

7. Handling missed dose, overdose of Enarenal 5mg

Missed dose: If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and take the next scheduled dose. Do not take double the prescribed dose to avoid overdose.
Overdose: When enalapril overdose, patients often experience severe hypotension. In this case, treatment should be discontinued and the patient closely monitored, supportive measures and symptomatic treatment should be applied.
Perform gastric lavage, intravenous plasma and sodium chloride to maintain blood pressure and treat electrolyte imbalance, hemodialysis can remove enalapril from the circulation.
If an overdose occurs, immediately take the patient to the nearest hospital or medical center for timely and effective treatment.

8. How to store Enarena 5mg

The medicine should be stored in a cool and dry place, with a room temperature below 30 degrees Celsius with a temperature below 30 degrees Celsius, away from moisture and away from direct sunlight. It is necessary to keep the medicine out of sight and reach of children, to avoid letting children play and take the wrong medicine, which affects the health of children.
If the medicine is expired or no longer used, do not throw the medicine in the toilet or under the tap for daily use, but contact your doctor or waste disposal company for instructions on how to safely dispose of the medicine. whole.
Above is all the information about Enarenaline that everyone needs to know to use the drug safely and achieve the best therapeutic effect when indicated for use.
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