This is an automatically translated article.
Eldoper is a medicine to treat diarrhea in the form of capsules. This drug is often indicated in the treatment of acute and chronic diarrhea, loose stools, and idiopathic diarrhea, including in people with AIDS.
1. What is Eldoper? What is Eldoper used for?
Drug name: Eldoper Dosage form: Capsules Category: Gastrointestinal drugs 1.1. Ingredients of Eldoper: Loperamide hydrochloride with a concentration of 2mg/tablet is the main ingredient in Eldoper. The drug has a stimulating effect on gastrointestinal contractions and increases the tone of the anal sphincter. Loperamide is rapidly absorbed from the intestine, usually excreted in the feces and urine. The drug is prepared in the form of hard capsules, packed into a box of 10 blisters, each blister contains 10 tablets. 1.2. Pharmacodynamics of the drug Eldoper Loperamide is a pharmaceutical ingredient containing active ingredients that bind to opiate receptors in the intestinal wall, reducing mucosal irritation and stimulating gastrointestinal contractions. Eldoper is effective in reducing intestinal peristalsis, prolonging the circulation time in the intestinal lumen. Loperamide increases the tone of the anal sphincter, thereby reducing urgency in the incontinence reflex.
The reason is because the drug has a high affinity for the intestine and is metabolized mainly in the first pass through the liver, so it is difficult to reach the circulatory system. Loperamide inhibits intestinal motility due to its direct peripheral effect on the intestinal wall. Therefore, loperamide-containing drugs can be used reasonably to treat signs of acute and chronic diarrhea, increase circulation time and time to absorption in people after open airway surgery. colon.
1.3. Pharmacokinetics of Eldoper Pharmacokinetics Loperamide is readily absorbed from the intestine (approximately 40% of a dose of loperamide is absorbed from the intestine) but is largely filtered and metabolized by the liver to the inactive form and excreted in the feces. urine both unchanged and metabolized. The concentration of the drug excreted in breast milk is relatively low. The binding capacity of the drug to plasma proteins is about 97%. The half-life of loperamide in humans ranges from 9 to 14 hours. Eldoper is eliminated mainly in the faeces.
1.4. Effects of Eldoper Drug Loperamide is a medicine for acute diarrhea of unknown etiology and some chronic diarrhea conditions. This is a synthetic form of opiate that at usual therapeutic doses has little effect on the central nervous system. Active ingredient Loperamide reduces intestinal motility, reduces gastrointestinal secretion capacity and increases anal sphincter tone. Eldoper also has the effect of prolonging the transit time through the intestines, increasing the transport of fluids and electrolytes, and reducing the amount of stool. This effect is related to a decrease in the release of acetylcholine and prostaglandins.
2. What disease does Eldoper treat?
Eldoper drug has the following therapeutic effects:
Relieves signs and symptoms of acute nonspecific diarrhea, chronic diarrhea caused by intestinal inflammation. Reduces stool volume for people who have had an ileostomy. Symptomatic treatment of acute diarrheal disease in adults and children 12 years of age and older Symptomatic treatment of acute episodes of diarrhea associated with irritable bowel syndrome in adults 18 years of age and older undergoing treatment preliminary diagnosis.
3. Usage and dosage of Eldoper
3.1. How to take Eldoper Eldoper is made in capsule form and is taken orally, you should take it with a sufficient amount of boiled and cooled water. You need to pay attention to follow the treatment dose and time of using Eldoper that your treating doctor recommends.
3.2. Dosage of Eldoper For the cases of using Eldoper to treat acute diarrhea in adults, the usual treatment dose is: Initially used with the first therapeutic dose of 2 tablets/time. then if after each diarrhea for people who use 1 tablet at a time, usually give people 3 or 4 tablets in a day. For children aged 2 to 5 years with a weight of about 13 to 20 kg, Eldoper is used to treat diarrhea with the usual dose of 3mg of the drug per day (equivalent to 3/2 tablets). ) For subjects who are children aged 6 to 8 years old with a weight of about 20 to 30 kg, Eldoper is used to treat diarrhea with a treatment dose of 4mg of the drug equivalent to 2 tablets per day. Children aged 8 to 12 years old with a weight greater than 30kg should use Eldoper to treat diarrhea with a treatment dose of 6mg of the drug equivalent to 3 tablets per day. If you have chronic diarrhea, it is used with a therapeutic dose of 2 to 4 tablets / day with the first dose, then depending on the case of treatment, the dose is appropriate to the specific case until the stool is visible. gelation. When using Eldoper, patients need to follow the dose prescribed by the doctor and pay attention to avoid unwanted effects caused by overdose, so patients should not take more than 8 tablets per day, even during treatment for acute or chronic diarrhea. 3.3. Handling under or overdosage When the therapeutic dose is under or overdosed Eldoper can cause you to experience unwanted effects. For forgetting to take a dose, the patient's health is usually not affected. However, the effectiveness of the treatment process will be reduced. And if you take an overdose of the drug, side effects can easily arise. You need to know how to handle it so that you can avoid the risks when encountering any situation.
In case of missing dose:
Only happens when you take Eldoper to treat chronic diarrhea. You should take it as soon as you remember the missed dose If it is too close to the time for your next dose, skip the missed dose Avoid making up for a dose by taking double the dose. Use for a single dose In case of overdose: You may experience clinical signs such as dizziness, abdominal pain, constipation... You need to take the initiative to notify the treating doctor to receive prompt care. time.
4. Undesirable effects of Eldoper
When using Eldoper medicine, you may experience some unwanted effects related to the immune system, but with rare frequency such as: anaphylaxis or hypersensitivity reactions. Some effects related to the nervous system may be encountered when using the drug such as headache, dizziness. Some undesirable effects related to digestion may occur after using Eldoper such as constipation, nausea, flatulence with frequent frequency, especially can cause bowel obstruction in young children, so care should be taken when using the drug for this object. Some other undesirable effects on the digestive system may occur such as abdominal pain, vomiting, discomfort or dry mouth,... However, the frequency is less common when taking Eldoper. Some unwanted effects on the skin when using Eldoper drugs such as rash, itching, but the frequency is less common. Some undesirable effects are more serious such as: toxic epidermal necrolysis, Stevens-Johnson syndrome, but the frequency is rare. Undesirable effects on the urinary system when using Eldoper are: urinary retention, but the frequency is rare. When experiencing the above-mentioned undesirable effects, the patient should report it to the treating doctor, especially if constipation occurs for treatment.
5. Eldoper drug interactions
When Eldoper is used concurrently with some other drugs that inhibit P-glycoprotein such as quinidine, ritonavir may increase the concentration of the drug in the blood, because the drug is transported by P-glycoprotein, but not yet. whether it is clinically significant or not. Concomitant use of Eldoper with Itraconazole or Gemfibrozil or with both may increase the concentration of the drug in the blood. When Eldoper is used simultaneously with drugs containing Desmopressin, due to the effect of reducing intestinal motility of the drug, it is possible to interact with Desmopressin to increase absorption, thereby increasing the concentration of this drug in the blood.
6. Some notes when using Eldoper
6.1. Contraindications of Eldoper: Do not use Eldoper for children under 12 years old and the elderly. The drug should not be used in patients with acute ulcerative colitis or pseudomembranous colitis caused by broad-spectrum antibiotics. People with acute dysentery, characterized by blood in the stools and high fever. Patients with acute ulcerative colitis. People with enteritis caused by invasive bacteria. Vigorous activities that cause inhibition of intestinal motility should be avoided. Eldoper must be discontinued as soon as intestinal obstruction, constipation, distention occurs. Hypersensitivity to drug components: acute infectious diarrhea caused by bacteria capable of penetrating deep into the intestinal mucosa such as infection with E.coli, Salmonella, Shigella, severe liver failure. 6.2. Note to other special populations For pregnant women: Eldoper belongs to the Pregnancy Category C subgroup. Although there are no data indicating adverse effects on the fetus, the drug is not recommended. Use in pregnant women, so only use when absolutely necessary when the benefits outweigh the risks. Lactation: The drug Loperamide is present in breast milk when the mother uses the drug, so it should be used with caution in nursing subjects. Eldoper is not recommended for use in this population, only used when absolutely necessary to ensure safety for the baby and should consider giving formula milk when the mother uses Eldoper. Eldoper is an antidiarrheal medicine that comes in the form of a capsule. This drug is often indicated in the treatment of acute and chronic diarrhea, loose stools, and idiopathic diarrhea. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
