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Esomeprazole injection is indicated for use as an alternative therapy when the patient's oral administration is inappropriate. Edizone medicine 40mg containing this active ingredient is very popularly used today in clinical practice. So how is Edizone 40mg used?1. What is Edizone 40mg?
Edizone 40mg is a drug product of Laboratorios Normon, S.A. - Spain is prepared in the form of lyophilized powder for injection and infusion. Each vial of Edizone 40mg contains Esomeprazole Sodium equivalent to Esomeprazole 40mg content and the system of excipients is just enough for 1 vial. Esomeprazole is an active ingredient in the group of proton pump inhibitors in the stomach, the drug concentrates and transforms into the active form in the secretory tubules of the cells, thereby giving an irreversible inhibitory effect on the enzyme H + / K+ - ATPase, prevents the release of gastric acid.
2. Effects of Edizone 40mg
Indications of Edizone 40mg:
Edizone 40mg is used to fight gastric acid secretion in case the patient cannot use esomeprazole orally as follows:
Indication Edizone 40mg for adults:
Reflux disease gastroesophageal reflux disease in patients with esophagitis and/or severe reflux symptoms; Prevention of re-bleeding after endoscopic procedures for acute hemorrhagic peptic ulcers. Indications Edizone 40mg for children from 1 to 18 years old: indicated in reflux esophagitis or severe reflux symptoms.
3. How to take Edizone 40mg
Edizone 40mg drug is used by injection or intravenous infusion.
Intravenous injection of Edizone 40mg:
40mg dose: Inject Edizone 40mg slowly with 5ml of solution for injection for at least 3 minutes; Dose 20mg: Inject Edizone with 2.5ml or half solution for injection over 3 minutes; 10mg dose: Inject 1.25 ml of solution for injection over a minimum of 3 minutes. Intravenous infusion of Edizone 40mg:
40mg dose: Edizone 40mg drug solution infusion for 10 - 30 minutes. Dose 20mg: Infuse 1⁄2 solution for injection Edizone 40mg in 10-30 minutes. 10mg dose: Infuse 1⁄4 solution for injection over 10-30 minutes. 80mg bolus dose: Infusion over 30 minutes; Dose 8mg/hour: Perform continuous infusion of Edizone for 71.5 hours. How to make Edizone 40mg injection solution:
Dose of Edizone 40mg intravenously: Add 5ml of 0.9% sodium chloride solution for injection into the vial to get a concentration of 8mg/ml. Doses of 20mg, 10mg intravenously: Take 1⁄2 and 1⁄4 of solution for injection, respectively, to mix into the vial. 40mg intravenous infusion: mix the vial with 100ml of 0.9% sodium chloride solution; Dose of 80mg intravenous infusion: Dissolve the powder of 2 vials with 100mg of 0.9% sodium chloride solution. Attention when using Edizone 40mg:
Edizone solution after being mixed must be clear, colorless or very light yellow, without foreign particles to be used; The unused portion of Edizone 40mg medicine must be discarded immediately. Use Edizone 40mg immediately after mixing.
4. Dosage of Edizone 40mg
Refer to the dose below: Use 1 time per day.
Adults:
Anti-acid secretion in patients not using oral: 20 - 40mg/day; Reflux esophagitis: 40mg/day; Severe reflux: 20mg/day; Treatment and prevention of stomach ulcers caused by NSAIDs: 20mg/day; Prevention of re-bleeding: 80mg bolus intravenously over 30 minutes followed by a continuous infusion of 8mg/hour for 3 days, ending the intravenous infusion with an oral acid-suppressor. Children from 1 to 11 years old:
Reflux esophagitis: children weighing < 20kg: 10mg/day, weighing ≥ 20kg: 10 or 20mg/day; Symptomatic treatment of reflux: 10mg/day. Children 12 - 18 years old:
Reflux esophagitis: dose of Edizon e 40mg/day; Symptomatic treatment of GERD: 20mg/day.
5. Contraindications Edizone 40mg
Do not use Edizone 40mg in the following cases:
Hypersensitivity to Esomeprazole or other Benzimidazole derivatives; I am taking Nelfinavir.
6. Undesirable effects of Edizone 40mg
In the process of taking Edizone 40mg, some unwanted effects may occur such as:
Common: Headache, abdominal pain, diarrhea, constipation, indigestion, nausea, vomiting, reactions at the site injection; Uncommon: Fractures of hip, wrist or spine, urticaria, rash, pruritus, dermatitis, elevated liver enzymes, dizziness, dizziness, somnolence, paresthesia, blurred vision, insomnia, dry mouth, edema Peripheral; Rare: Leukopenia, thrombocytopenia, blood sodium, agitation, depression, confusion, taste disturbances, bronchospasm, gastrointestinal candidiasis, stomatitis, hepatitis, possibly with biliary obstruction , hair loss, sensitivity to light, increased sweating, malaise; Very rare: Interstitial nephritis, gynecomastia in men, muscle weakness, erythema multiforme...; Frequency not known: hypomagnesaemia, gastritis.
7. Edizone 40mg drug interactions with other drugs
Edizone 40mg drug interactions may occur with other drugs when combined, such as:
Edizone 40mg drug affects the effectiveness of pH-dependent absorbed drugs such as: Ketoconazole, Itraconazole, Atazanavir, Nelfinavir... because Esomeprazole changes gastric pH; Edizone 40mg drug increases the bioavailability of Digoxin ; Edizone 40mg drug increases the plasma concentration of drugs metabolised by CYP2C19 such as: Phenytoin, Imipramine, Diazepam... leading to an increased risk of side effects; Edizone 40mg interacts with CYP3A4 inhibitors (Clarithromycin) increasing exposure to Esomeprazole; Edizone 40mg drug interacts with inducers of CYP2C19 and/or CYP3A4 such as: Rifampicin; St. John' wort causes a decrease in Esomeprazole plasma concentrations, reducing the therapeutic effect of Edizone 40mg.
8. Note when using and storing Edizone 40mg
Edizone 40mg drug for pregnant and breast-feeding women: It is not known whether Edizone 40mg drug will cause adverse reactions to the development of the fetus and breast-feeding children, therefore, do not arbitrarily use Edizone medicine. 40mg without a doctor's prescription. Edizone 40mg drug for drivers and machine operators: Edizone 40mg drugs can cause headaches, dizziness, insomnia... should be used with caution for the above subjects. If the patient shows signs of abnormal weight loss, difficulty swallowing, black stools, vomiting blood, etc., it is necessary to exclude the possibility of malignancy before Esomeprazole treatment. Edizone 40mg slightly increases the risk of gastrointestinal infections such as Salmonella and Campylobacter infections. Some patients experienced severe hypomagnesaemia for at least 3 months of treatment and most patients received Edizone 40mg for 1 year. Increased hip, wrist and spine fractures if Edizone 40mg is used in high doses and lasts for more than 1 year, especially in the elderly or people with high risk factors. Store Edizone 40mg medicine in a closed, dry, protected from light, below 30°C, do not freeze.
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