Uses of Duragesic

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1. Uses of the drug Duragesic

Each Duragesic drug patch has the main ingredient Fentanyl 8.4mg and excipients. Ingredients Fentanyl is an Opioid pain reliever, a Phenylpiperidine derivative. Its main effects are pain relief and sedation. The Duragesic patch 50μg/h is indicated for the management of severe chronic pain requiring long-term continuous opioid use.
Contraindications to the use of Duragesic:
People with hypersensitivity, at risk of allergies to the drug's ingredients; Patients with acute or postoperative pain (because there is no opportunity for dose titration during short-term use, due to severe or life-threatening hypoventilation); Patient has severe respiratory failure.

2. Usage and dosage of Duragesic

2.1 How to use Before applying the patch on the skin, the patient should clean the skin with clean water and dry it; Remove the patch from the bag, apply it to the area to be treated, gently press for about 30 seconds to make sure the patch is firmly attached to the skin. *Note:
Should stick the patch on non-irritated, flat skin, need to avoid exposure to light, on the torso and on the upper arm; For young children, priority should be given to the back area; With hairy skin, hair should be removed by clipping (not shaving); Stick the patch continuously for 72 hours; After removing the old patch, the new patch should not be immediately applied to the old position, but should wait for about 2-3 days. 2.2 Dosage The dose of Duragesic drug is calculated based on the patient's current Opioid dose, according to the doctor's instructions: Oral morphine dose 30 - 44μg/24h: 12μg/h dose; Oral morphine dose 45-134μg/24h: Use a dose of 25μg/h; Duragesic has not been studied in children under 2 years of age. The drug should only be used for children 2 years of age and older who are able to tolerate Opioids; Duragesic should only be used in patients who have tolerated opioids. Other factors that need to be considered include: The patient's current and medication status including age, body size, debilitation, and Opioid tolerance. Fentanyl overdose symptoms are prolonged pharmacological effects of the drug, the most serious effect is respiratory depression. The treatment is to remove the patch immediately, take the patient to the nearest medical facility for timely monitoring and treatment.

3. Side effects of the drug Duragesic

The side effects that patients may encounter when using Duragesic include:
Very common: Dizziness, headache, drowsiness, nausea, vomiting, constipation; Common: Hypersensitivity, depression, anxiety, insomnia, hallucinations, confused state, anorexia, tremor, dysesthesia, tachycardia, increased blood pressure, dry mouth, diarrhea, abdominal pain, Few Common: Excitement, agitation, disorientation, amnesia, loss of consciousness, decreased level of consciousness, cyanosis, bradycardia, blurred vision, respiratory failure, low blood pressure, skin disorders, illness eczema, atopic dermatitis, dermatitis, contact dermatitis, erectile dysfunction and sexual dysfunction, local reactions; Rare: Apnea, hypoventilation, dermatitis or eczema in the area of ​​application. Patients should inform their doctor about the side effects of Duragesic for guidance and timely treatment.

4. Be careful when using the drug Duragesic

Fentanyl component of the drug crosses the placenta, so its use in pregnant women can cause respiratory depression in the newborn. Duragesic should not be used during pregnancy; Fentanyl component of the drug is secreted into breast milk, may cause respiratory depression in children, so the drug should not be used for breastfeeding women; Duragesic drugs may impair cognitive function, affect the ability to drive or operate machines, so caution should be exercised when using the drug in this group of subjects; Special attention when using the drug in people with chronic constipation. If the patient is suspected of intestinal obstruction due to paralytic ileus, the drug should be stopped immediately; Elderly patients taking Duragesic should be carefully monitored for signs of toxicity, and if necessary, the dose should be reduced; Avoid exposing the body part with the patch to a heat source; Use caution when using Duragesic in patients with liver failure, kidney failure, cardiovascular disease; Duragesic should only be used as directed by a doctor.

5. Duragesic drug interactions

Some Duragesic drug interactions include:
When Duragesic is combined with other central nervous system depressants (Benzodiazepines and tranquilizers, Opioids, general anesthetics, sedating antihistamines, Phenothiazines, alcohol, CNS depressants) and skeletal muscle relaxants may lead to a risk of hypotension, respiratory depression, deep sedation, coma or death; Concomitant administration of Duragesic with MAO inhibitors may potentiate the Opiate or Serotonergic-type effects; Concomitant use of Duragesic with Serotonergic drugs may increase the risk of Serotonin syndrome; The drugs Buprenorphine, Nalbuphine or Pentazocine partially antagonize the analgesic effect of Duragesic, which may cause withdrawal symptoms in Opioid dependent patients; Cytochrome P450 3A4 inhibitors may increase Duragesic plasma concentrations, possibly increasing/prolonging therapeutic and side effects, even causing severe respiratory depression; Concomitant use of Duragesic with CYP3A4 inducers may reduce plasma concentrations, reducing the therapeutic effect. When using Duragesic, the patient should absolutely follow the doctor's instructions on how to use and dose. At the same time, to avoid the risk of drug interactions or side effects, patients should inform their doctors about the drugs they are using, the medical conditions they are suffering from to receive appropriate advice.

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