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Donova contains the main ingredient Diacerein, which is used in the symptomatic treatment of some osteoarthritis. So what is the effect of Donova drug, please read the following shared content.
1. What is Donova?
Each Donova hard capsule contains:
Active ingredients: Diacerein 50mg. Excipients: Magnesium stearate, Sodium starch glycolate,Lactose, Povidon K30, hard gelatin capsule (No. 1). Dosage form: Donova drug is produced in the form of hard capsules by Domesco Medical Import-Export Joint Stock Company.
Packing specifications: Box of 1 blister x 10 tablets, box of 3 blisters x 10 tablets and box of 10 blisters x 10 tablets.
2. What are the effects of Donova?
Diacerein is an anthraquinone derivative with moderate anti-inflammatory activity. Donova has analgesic, non-steroidal anti-inflammatory effects, is used in the treatment of manifestations of osteoarthritis.3. Donova is contraindicated for which subjects?
Donova 50mg is contraindicated for use with some subjects as follows:
Patients with hypersensitivity to the components of Donova drug. The patient has a history of hypersensitivity, allergy to Anthraquinone derivatives. The patient is suffering from certain liver diseases or has a history of liver disease. People with a history of severe diarrhea, dehydration, and hypokalemia need hospital treatment. People with inflammatory bowel disease such as: Crohn's disease, ulcerative colitis, ... People with intestinal obstruction syndrome or partial obstruction. Patients with abdominal pain syndrome have not found the cause. Children under 15 years of age should not use Donova. Women who are pregnant or breastfeeding should not use Donova. Patients with congenital galactose disease, glucose and galactose malabsorption syndrome or lactase deficiency.
4. Dosage and how to use Donova 50mg
Patients only use the right dose of medicine in the prescription and according to the doctor's instructions.
4.1 Donova Dosage Recommended starting dose: 50mg x 1 time/day. May be combined with NSAIDs or analgesics for 2 to 4 weeks. Dose increase at the next time: 50mg x 2 times / day (morning and evening). For patients with severe renal impairment (creatinine < 30 ml/min) the daily dose is halved. 4.2 How to use Donova Donova is used orally, using the drug with a sufficient amount of water 250ml and taking the drug with meals. Donova should be swallowed whole (do not break). If you forget to take a dose of Donova, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose of Donova and continue taking the next dose at the usual time. A double dose of Donova should not be used to make up for a missed dose.
5. Some side effects when using Donova 50mg
At therapeutic doses, Donova is well tolerated. However, during the use of Donova, patients may still experience side effects such as:
Digestive disorders: Diarrhea, abdominal pain, increased intestinal motility and flatulence. (Severe cases of diarrhea can cause complications such as dehydration and electrolyte imbalance.) Hepatobiliary system disorders: Increased serum liver enzymes. Skin and Subcutaneous Tissue Disorders: Pruritus, skin rash and eczema. Risk of cardiovascular thrombosis Tell your doctor about any side effects you experience while using Donova.
6. Donova drug interactions
Some drug interactions may be encountered during use such as:
Using drugs containing the active ingredient Diacerein can cause diarrhea and hypokalemia. Therefore, caution should be exercised when diacerein is used concomitantly with diuretics (loop diuretics and thiazides) or with cardiac glycosides (Digitoxin, Digoxin) because the combination may increase the risk of arrhythmias. Drugs containing salts, oxides and hydroxides of aluminum, calcium and magnesium: Decreased absorption of Diacerein (Diacerein can be used away from these drugs for more than 2 hours). Antibiotics (eg, amoxicillin and clavulanic acid) and/or chemotherapy because of the potential for increased risk of gastrointestinal events.
7. Donova overdose and how to handle it
Symptoms of Donova overdose are persistent diarrhea.
Guidelines for treatment of overdose Donova:
Restore electrolyte balance in the symptomatic treatment of overdose. Actively monitor the patient for appropriate treatment measures. When prescribed Donova 50mg, patients should strictly follow all instructions of the doctor to ensure the best treatment effect and limit the unpredictable side effects caused by the drug.
