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Dexastad 4mg drug contains the active ingredient Dexamethasone which is indicated in many diseases such as rheumatoid arthritis, cerebral edema and shock due to many causes... Let's learn about the uses, the notes when using the drug Dexastad 4mg through the post. write below.
1. Uses of the drug Dexastad 4mg
"What is Dexastad 4mg?". Dexastad medicine 4mg contains the active ingredient Dexamethasone, which is prepared in the form of an infusion solution. Dexamethasone is a synthetic glucocorticoid with anti-inflammatory, anti-allergic and immunosuppressive effects. The drug has anti-inflammatory activity 30 times stronger than Hydrocortisone and 7 times stronger than Prednisolone. At pharmacologically active doses, systemic dexamethasone inhibits the secretion of corticotrophin by the pituitary gland (ACTH), and inhibits the secretion of endogenous corticosteroid hormone by the adrenal glands. In the case of long-term corticosteroid therapy, only the lowest effective dose should be used and often used as an adjunct to therapy. When discontinuing use, the dose should be gradually reduced and should not be stopped abruptly.
Dexastad 4mg is indicated in the following cases:
Used as non-specific therapy in the active treatment of bronchial asthma, blood transfusion reactions, severe allergies, laryngitis hissing; Combination in the treatment of shock, cerebral edema due to various causes; Use as hormone replacement therapy in patients whose adrenal glands do not produce adequate amounts of corticosteroids; Support in the treatment of pneumococcal meningitis; Injected around joints and in joints in patients with osteoarthritis, rheumatoid arthritis, periarthritis.
2. Dosage of Dexastad 4mg
Dexastad medicine 4mg is prepared in the form of intravenous injection, intramuscular injection, intra-articular or soft-tissue injection, intralesional injection. The dose of the drug used is prescribed by the treating doctor based on the disease condition and the patient's response. Some recommendations on the dose of Dexastad 4mg are as follows:
Adults: The recommended dose is from 0.5 to 24mg / day:
Shock from causes: Use a dose of 1 - 6mg/kg Dexastad IV once or 40mg every 2 - 6 hours. High-dose therapy should be maintained until the patient is stable, but not for more than 48-72 hours; Cerebral edema: 10 mg intravenously, then repeated intramuscularly every 6 hours until symptoms improve. Response to the drug manifests itself in 12-24 hours and the dose may be reduced after 2-4 days, gradually stopping treatment over 5-7 days. Where possible, replace parenteral route with oral dexamethasone 1-3 mg/time x 3 times/day; Allergies: Use intramuscular dose of 4mg - 8mg of Dexamethasone phosphate in the first day. Days 2 and 3, taking oral dexamethasone 3mg divided into 2 times. On the 4th day, take 1mg orally divided into 2 times. Days 5 and 6 use a single dose of Dexamethasone 0.75mg, then stop taking the drug; Prevention of postoperative vomiting: Intramuscular dose of 10-20mg near the end of surgery; Inflammatory disease: Administer intra-articular, intra-soft tissue or lesional route with dosage depending on condition and site of injection.
3. Side effects of Dexastad 4mg
Dexastad 4mg medicine can cause some side effects as follows:
Common: Sodium retention, hypokalemia, edema and hypertension, decreased ACTH secretion, Cushing's syndrome, decreased glucose tolerance, gland atrophy adrenal gland, menstrual disorders, osteoporosis, reversible muscular atrophy, spina bifida, pathological fracture, aseptic osteonecrosis, bleeding ulcer, peptic ulcer, acute myelitis, dermatitis, rash skin...; Uncommon: Hypersensitivity, anaphylaxis, venous thrombosis, leukocytosis, weight gain, nausea, malaise, infectious abscess, hiccups...; Discontinuation symptoms: Rapid dose reduction after a long period of treatment can lead to acute adrenal insufficiency, hypotension, and death. In case of experiencing side effects of Dexastad 4mg, the patient should notify the treating doctor for timely treatment.
4. Notes when using Dexastad 4mg
Contraindicated to use Dexastad 4mg drug in patients with hypersensitivity to any component of the drug, patients with viral infections, systemic fungal infections or tuberculosis, gonorrhea infections that have not been controlled by antibacterial drugs.
Use caution when using Dexastad 4mg in the following cases:
Patients with bacterial infection or suspected bacterial infection; Patients with osteoporosis, psychosis, recent bowel surgery, diabetes, heart failure, hypertension, kidney failure, tuberculosis... should be closely monitored in case of using Dexamethasone; Long-term corticosteroid therapy may reduce the adrenal gland's ability to excrete corticosteroids. Therefore, when stopping the drug, the patient should be stopped gradually to minimize the symptoms of corticosteroid deficiency. For pregnant women, lactating women: Do not use Dexastad in the treatment of these subjects.
5. Drug interactions
Drugs Dexastad 4mg can cause some interactions as follows:
Phenytoin, Barbiturates, Carbamazepine, Ephedrine, Aminoglutethimid... increases the clearance of Corticosteroids, thus reducing the therapeutic effect of Dexastad; Corticosteroids reduce the hypoglycemic effect of antidiabetic drugs (including insulin), reduce the effect of antihypertensive drugs and diuretics; Dexastad enhances the hypokalemic effect of Thiazide diuretics, Acetazolamide; The effect of Cumarin-derivative anticoagulants is increased when used concomitantly with Dexastad. Therefore, patients should be closely monitored Prothrombin time in the case of mandatory co-administration; Salicylate clearance is increased with concomitant use of corticosteroids. Possible drug interactions that reduce the therapeutic effect of Dexastad and increase the risk of unwanted effects. Therefore, to ensure safety and effectiveness, patients need to inform their doctors about the drugs and functional foods they are using before being treated with Dexastad 4mg.
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