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What is the effect of Darinol 300mg, is it a treatment for gout? In fact, Darinol 300mg is a drug that reduces uric acid levels in the blood and one of its indications is to treat arthritis caused by chronic gout.1. What is the effect of the drug Darinol 300mg?
Darinol 300mg belongs to the group of pain relievers and antipyretics, non-steroidal anti-inflammatory drugs, drugs for the treatment of osteoarthritis, with the main ingredient being Allopurinol 300mg. Allopurinol is effective in reducing serum and urine uric acid levels. In addition, Allopurinol also works to prevent arthritis progression due to gout, kidney disease caused by urate.Darinol 300mg drug is made in the form of tablets and is indicated for the treatment of complications when uric acid levels increase, including: Arthritis due to chronic gout, kidney stones, recurrent calcium oxalate kidney stones, reduce uric acid levels in patients undergoing chemotherapy for malignancies, lymphomas, and leukemias.
2. How to use and dose Darinol 300mg
Darinol 300mg is taken orally, taken with water and should be taken after meals. The patient should take the medicine according to the prescription and instructions of the doctor. Dosage should be started with the lowest dose and can then be increased gradually.Dosage of Darinol 300mg in adults is as follows:
Dosage is based on weight: 2 - 10mg/kg body weight/day. Dosage is based on the condition and severity of the disease: Mild disease and early stage use 100-200mg/day; For moderate and advanced disease, the dose is 300 - 600mg/day; For severe disease, the dose is 700-900mg/day. Dosage of Darinol 300mg in children is as follows:
Children under 15 years old: Dosage is based on the child's weight, 10-20mg/kg body weight/day, the maximum should not exceed 400mg/day. The use of Darinol 300mg in children should be limited, except in some cases directly prescribed by a doctor. Dosage of Darinol 300mg in patients with liver and kidney failure is recommended as follows:
Liver failure : Use a lower dose than usual. In the initial phase of taking the drug, it is necessary to periodically check liver function. Severe renal impairment: Take a lower dose than usual or as specifically directed by your doctor. The dose can be less than 100mg/day or 100mg every other day. Hemodialysis patients: Increase the dose of Darinol 300mg to 300-400mg after each hemodialysis session because of the rapid elimination of the drug. Overdose of Darinol 300mg only appeared when taking a dose of 20g with symptoms such as dizziness, diarrhea, nausea, vomiting, but no allergic reactions were recorded.
In case of overdose of Darinol 300mg, the patient needs to be replenished with water to help the body quickly eliminate the drug through urination. If necessary, hemodialysis can be performed.
3. Side effects of the drug Darinol 300mg
Darinol 300mg may cause some unwanted side effects with the frequency of occurrence as follows:Common: Itching, rash, skin rash. Uncommon: Vasculitis, arthralgia, fever, chills, leukopenia or leukopenia, lymphadenopathy. Rare: Hypertension, headache, dizziness, somnolence, peripheral neuropathy, alopecia, alopecia, abdominal pain, diarrhea, nausea, paresthesia. If you see any strange symptoms after taking Darinol 300mg, the patient should immediately report it to a doctor or go to a medical facility for examination.
4. Some notes when taking Darinol 300mg
Do not use Darinol 300mg in people with hypersensitivity to the ingredients of the drug, patients with severe renal or hepatic impairment, pregnant or lactating women, patients with elevated uric acid but no symptoms, patients with acute gout. acute or acute attack of chronic gout. Before starting the drug Darinol 300mg, the patient should be cured of acute gout for at least 15 days because in the initial stage of taking the drug, the active ingredient Allopurinol can increase the concentration of uric acid and urate in the blood plasma, causing make the disease worse. Patients should take the drug at the lowest starting dose, then gradually increase the dose. For the prevention of acute attacks, colchicine and an NSAID should be combined for at least the first 3 months of treatment. As mentioned above, Darinol 300mg should not be used in the treatment of acute gout. But if an acute attack occurs while taking the drug, the patient needs to continue taking Darinol and take another course to treat the acute attack of gout. After taking Darinol 300mg, if you see any abnormality or symptoms do not improve, the patient should stop taking the drug and consult a doctor. Patients with renal or hepatic impairment who take Darinol 300mg should be adjusted to reduce the dose and closely monitored during drug use. While taking the drug Darinol 300mg, if the patient uses alcohol, beer can cause the concentration of uric acid in the blood to increase and the effectiveness of the drug to decrease. Limit the activity of driving or operating, operating machinery when using Darinol 300mg because the drug can cause drowsiness, dizziness. Darinol 300mg may interact with the following drugs: Inhibits the metabolism of drugs azathioprine and mercaptopurine when taken together, so the dose of these two drugs should be reduced to 1/4 or 1/3 of the therapeutic dose. normally; reduce the effectiveness of treatment if used together with aspirin or salicylates due to increased uric acid in the blood; There is an increased risk of side effects if taken with antihypertensive drugs of the ACE inhibitor class or thiazide diuretics (especially in patients with renal impairment). Darinol 300mg if used concurrently with amoxicillin or ampicillin will increase the risk of skin rash; use with anticoagulants dicoumarol or warfarin,... increases the risk of bleeding, so the dosage of these drugs should be adjusted. The use of the drug Darinol 300mg is to reduce uric acid levels in the blood and is used to treat complications caused by increased uric acid such as arthritis caused by acute gout, kidney stones,...Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
