Uses of Curam tab 625mg

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1. Uses of Curam tab

Curam medicine contains the active ingredient combination between amoxicillin and clavulanic acid in the form of Curam tab 625mg (containing 500mg amoxicillin and 125mg clavulanic acid) and Curam 1000mg drug (containing 875mg amoxicillin and 125mg clavulanic acid). The drug is indicated in the treatment of the following infections:
Sinusitis caused by well-defined acute bacterial species; Acute otitis media , community acquired pneumonia ; Acute exacerbation of chronic bronchitis has been confirmed; Pyelonephritis, cystitis ; Skin and soft tissue infections such as cellulitis, severe tooth abscesses, animal bites; Bone and joint infections, especially osteomyelitis.

2. Dosage of Curam tab

Curam 625mg and Curam tab 1000mg 10x8's dose depends on the patient's medical condition. The drug is taken orally, and should be taken at the beginning of a meal to help optimize the absorption of amoxicillin/clavulanic acid and minimize the possibility of gastrointestinal intolerance.
The dose of Curam drug selected in the treatment of bacterial infections may be based on the drug's susceptibility to pathogenic bacteria, specifically as follows:
Infection severity and infection site: The use of Curam tab 625mg or Curam tablets 1000mg (different ratio between amoxicillin and clavulanic acid) should be considered as needed:
For adults and children weighing 40 kg or more, a daily dose of 1,500 mg amoxicillin/375 mg clavulanic acid. The dose may be adjusted depending on the patient's response; The duration of treatment depends on the severity of the infection and the patient's ability to respond. In some cases of bacterial infections (eg, osteomyelitis), the duration of treatment may be longer. The course of drug therapy should not last more than 14 days without evaluation or review. Adults and children over 40kg: Take the dose of Curam tab 625mg is 1 tablet / time x 3 times / day. Children can be treated with Curam suspension or children's package (especially children 6 years of age and younger).
Elderly: No dose adjustment is required in this population.
Patients with renal impairment: Dosage is adjusted based on the maximum recommended dose of amoxicillin. Patients with renal failure with creatinine clearance greater than 30ml/min do not need to adjust the dose. Patients with creatinine clearance less than 10ml/min should take the recommended dose of 1 tablet of Curam tab 625mg x 1 time/day.
Patients with liver failure : Be careful when treating with Curam tab 1000mg, Curam drug tab 625mg and need to monitor liver function at regular dose intervals.

3. Side effects of the drug Curam tab

Curam tab can cause some side effects as follows:
Common: Diarrhea, Candida infection in mucous membranes and skin, vomiting, nausea; Uncommon: Headache, dizziness, dyspepsia, increased AST and/or ALT 5, pruritus, skin rash, urticaria, dyspepsia, headache, dizziness; Rare: Reversible leukopenia, erythema multiforme, thrombocytopenia; Frequency unknown: Overgrowth of susceptible organisms, reversible agranulocytosis, hemolytic anemia, prolonged bleeding time and prothrombin time, angioedema, anaphylaxis, syndrome-like serum sickness, hypersensitivity vasculitis, reversible hyperactivity, convulsions, antibiotic-associated colitis, hepatitis, cholestatic dermatitis, exfoliative bullous dermatitis...

4. Notes when using Curam tab

4.1. Contraindications Curam tab 625mg and 1000mg are contraindicated in the following cases:
Patients with hypersensitivity to any ingredient of Curam tab drug or hypersensitivity to any antibiotic of the penicillin group; Patients with a history of severe immediate hypersensitivity (eg, anaphylaxis) to beta-lactam drugs (eg, carbapenem, cephalosporin or monobactam); Patients with a history of jaundice or liver failure due to amoxicillin/clavulanic acid. 4.2. Precautions for use Before treatment with the antibiotic Curam, the patient should be carefully examined for previous hypersensitivity reactions to cephalosporins, penicillins or beta-lactam antibiotics. Serious (possibly fatal) hypersensitivity reactions have been reported in patients being treated with penicillins. Hypersensitivity reactions are more likely to occur in patients with a history of hypersensitivity to penicillins and in patients with a predisposition to atopy. In the event of an allergic reaction, the patient should immediately discontinue drug therapy and notify the treating physician so that an appropriate alternative treatment regimen can be established. For pathogens resistant to beta-lactam drugs that are not mediated by beta-lactamases, treatment with Curam tab is not recommended. Convulsions when taking the drug may occur in patients with renal failure or in patients treated with high doses of the drug. Avoid the use of Curam tab 1000 10x8's or Curam tab 625mg in patients with suspected infectious mononucleosis, because the occurrence of a measles-like rash after amoxicillin therapy has been associated with this condition. Long-term treatment with Curam can lead to overgrowth of resistant bacteria. Generalized erythema with fever during initial treatment combined with pustules may be indicative of an acute generalized pustular rash. Patients experiencing this reaction should discontinue Curam and any subsequent treatment with any form of amoxicillin is contraindicated. Hepatic side effects (mainly male and elderly patients) have been reported in association with long-term drug therapy. Therefore, caution should be exercised when using the drug in patients with evidence or history of liver disease. Antibiotic-associated colitis has been reported with nearly all antibacterial agents, and its severity can range from mild to life-threatening. Therefore, it is important to review and diagnose patients with diarrhea during and after antibiotic therapy. In case of colitis related to the use of antibiotics, treatment with Curam should be discontinued, and the treating doctor should be informed to have an appropriate alternative treatment regimen. In cases where long-term drug therapy is required, the patient should have the function of the organ systems (kidneys, liver and hematopoietic organs) evaluated periodically. Ability to drive and use machines: No adverse effects on the ability to drive or use machines have been reported. However, patients may experience unwanted effects such as convulsions, dizziness, allergic reactions... affecting the ability to drive, operate machinery... Pregnant women : Animal studies have shown that Amoxicillin/clavulanic acid has no harmful effects on pregnancy, embryonic development, pregnancy and postnatal development. Data on the use of Amoxicillin/clavulanic acid in pregnant women do not indicate an increased risk of birth defects. However, it is still advisable to avoid using the drug during pregnancy, unless directed by your doctor. Lactation: Both amoxicillin and clavulanic acid are excreted in breast milk and may cause diarrhea or fungal mucosal infections in breastfed infants. Therefore, the mother should stop breastfeeding during treatment with the drug. Curam should only be used in lactating women after being prescribed by a physician (benefit outweighs risk).

5. Curam tab drug interactions

Oral anticoagulants: Limit the simultaneous use of oral anticoagulants (warfarin, acenocoumarol) with amoxicillin. In cases where use is imperative, careful monitoring of prothrombin time or the internationally normalized ratio with the addition or discontinuation of amoxicillin is recommended. Methotrexate: Amoxicillin in particular and penicillin antibiotics in general can reduce the excretion of methotrexate, thereby increasing the side effects and toxicity of methotrexate. Probenecid: Concomitant use of Curam with probenecid is not recommended. Because probenecid reduces the renal tubular secretion of amoxicillin, leading to increased serum amoxicillin concentrations. Mycophenolate mofetil: There has been a reported risk of a 50% reduction in the starting dose of the active metabolite of mycophenolate mofetil (mycophenolic acid) when co-administered with the antibiotic amoxicillin. Curam tab contains an active ingredient that is a combination of amoxicillin and clavulanic acid. The drug is indicated in the treatment of infectious conditions such as inflammation of the upper and lower respiratory tract, acute sinusitis, otitis media, acute and chronic bronchitis. To ensure the effectiveness of treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, professional pharmacist.
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