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CoAprovel 300/12.5 mg is a prescription drug, the patient needs to be prescribed by a doctor. CoAprovel is an antihypertensive drug and is used to treat primary hypertension.
1. What is CoAprovel 300/12.5 mg?
CoAprovel 300/12.5 mg drug is used to treat primary hypertension. The drug is manufactured in France by the pharmaceutical company Sanofi Winthrop Industrie. CoAprovel is available as a peach-colored, oval, biconvex film-coated tablet. Various packing specifications: a blister of 14, 28, 30, 56, 84, 90 or 98 tablets. There may not be a full range of packaging on the market.
CoAprovel 300/12.5 mg drug is made up of the main ingredients Irbesartan and Hydrochlorothiazide and other excipients. Irbersartan helps to block the receptors that cause vasoconstriction and Hydrochlorothiazide has a diuretic effect as well as helps urine to pass quickly out of the body. Both active ingredients help lower blood pressure in patients.
2. What are the effects of CoAprovel 300/12.5 mg?
CoAprovel 300/12.5 mg is a combination of two drugs Irbesartan and Hydrochlorothiazide. Active ingredient Irbesartan belongs to the Angiotensin-II receptor antagonist group. This receptor is originally located on cell membranes in tissues, but when attached to blood vessels, Angiotensin-II constricts blood vessels and causes an increase in blood pressure. Irbesartan blocks the process of binding this receptor to blood vessels, thereby dilating blood vessels, lowering circulating blood pressure, helping to lower blood pressure. The active ingredient Hydrochlorothiazide is a group of thiazide diuretics, which increase the amount of urine excreted, thereby lowering blood pressure.
The combination of these two agents helps lower blood pressure faster and better when compared to patients taking only one of the two agents to lower blood pressure. CoAprovel 300/12.5 mg is indicated for use in patients with primary hypertension and failure to control blood pressure with either individual active ingredient.
3. Usage of CoAprovel 300/12.5 mg
3.1. How to use CoAprovel 300/12.5 mg For the drug CoAprovel, patients can use it orally. Swallow the medicine whole with an appropriate amount of liquid, usually cooled boiled water. Absolutely do not deform the drug such as breaking, crushing, chewing because this causes the pharmacokinetics of CoAprovel to be different from the original purpose of the drug.
Regarding dosage and usage, patients should consult a doctor or pharmacist for further reference.
3.2. Dosage of CoAprovel 300/12.5 mg Take one tablet per day. CoAprovel is usually prescribed after a previous antihypertensive drug has failed to work. The patient's treating physician will advise further on how to transition from the previous product to the CoAprovel product.
3.3. Treatment of missed dose, overdosage Missed dose: When the patient forgets to take a dose during the day, take CoAprovel 300/12.5 mg as soon as he remembers. If it is almost time for your next dose, take your next dose as usual. Do not make up the dose, double the dose because it can cause an overdose.
Overdose: The patient goes to the nearest doctor or medical facility. Symptomatic treatment occurs in the event of an overdose, possibly with severe hypotension. May induce vomiting and gastric lavage.
Electrolyte transfusion and renal creatinine should be monitored. When hypotension occurs, the patient should be promptly recumbent, treated with rehydration and electrolyte replacement.
3.4. Contraindications CoAprovel 300/12.5 mg Patients with hypersensitivity to Irbesartan, to Hydrochlorothiazide or to any other ingredient of CoAprovel. The use of CoAprovel is contraindicated in pregnant and lactating women. Patients with liver failure, cirrhosis of the liver due to cholestasis or severe renal failure Patients with urinary tract stenosis, renal artery stenosis or other obstructions in urine excretion Patients with diseases that increase calcium levels or decreased potassium in the blood. Not for use by children under 18 years old
4. Note when using CoAprovel 300/12.5 mg
4.1 Side effects of CoAprovel 300/12.5 mg When using CoAprovel 300/12.5 mg, patients may experience unwanted side effects such as:
Headache, dizziness, fatigue, nausea/vomiting , Urinary abnormalities, increased indices and levels of renal function such as creatinine or blood urea Other rare reactions such as skin allergies (rash, urticaria) have been associated with the use of Irbesartan. 4.2 Drug Interactions CoAprovel 300/12.5 mg When co-administered with antihypertensive agents: the hypertensive effect is increased when concomitantly administered with antihypertensive agents Potassium-sparing diuretics, potassium supplements or Potassium-containing salt substitutes: the potassium-losing effects of hydrochlorothiazide are attenuated by their retention by irbersartan. Concomitant use of these drugs may increase serum potassium. Non-steroidal anti-inflammatory drugs: may reduce the therapeutic ability of CoAprovel by reducing diuresis, reducing urinary sodium excretion. 4.3 Storing CoAprovel 300/12.5 mg CoAprovel 300/12.5 mg Storing CoAprovel 300/12.5 mg in a cool, dry place, away from direct sunlight.
The appropriate storage temperature for CoAprovel medicine is below 30 degrees Celsius
The shelf life of CoAprovel medicine is from 24 months from the date of manufacture
Store the medicine and store the medicine in a place out of reach of children
CoAprovel 300/ 12.5 mg is a specific drug in cases where a single activity cannot control blood pressure. This drug is a prescription drug and requires a doctor's prescription to use it. Patients should carefully read the instructions for use and follow the dosage prescribed by the doctor.
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