This is an automatically translated article.
Claminat is a combination antibiotic used in the treatment of bacterial infections. The drug is mainly indicated in upper respiratory tract infections, skin and soft tissue infections.1. Uses of Claminat 500mg
Claminat is an antibiotic with two main active ingredients, including: Amoxicillin (as Amoxicillin trihydrate) with the content of 500mg and clavulanic acid (as Potassium clavulanate) with the content of 62.5mg.In which, Amoxicillin is a semi-synthetic beta-lactam antibiotic with a broad bactericidal spectrum against many Gram-positive and Gram-negative bacteria because it inhibits bacterial cell wall synthesis. But Amoxicillin antibiotic is very easily degraded by beta lactamase enzyme secreted by gram-negative bacteria and staphylococcus aureus, causing hydrolysis of beta lactam ring in the structure of Amoxicillin, so this antibiotic has limited effect and has no effect on these yeast-producing strains.
For component Clavulanic acid has a higher affinity than Amoxicillin, so it binds to some beta lactamase enzymes secreted by bacteria, making these enzymes not destroy the ring of beta lactam antibiotics. It has a high affinity for beta lactamases because clavulanic acid is structurally similar to penicillins and cephalosporins. Therefore, it was found that clavulanic acid has the ability to inhibit beta lactamase enzymes produced by most Gram-negative bacteria and Staphylococcus (yellow staphylococcus).
When these two substances are combined, clavulanic acid helps prevent Amoxicillin from being degraded by lactamases, extending the antibacterial spectrum of Amoxicillin to be effective against many common bacteria that produce beta lactamases resistant to Amoxicillin when used alone. . Co-administration with clavulanic acid did not alter the mechanism of action of Amoxicillin.
Thus, the antibiotic Claminat has antibacterial effects with a broad spectrum of action on both gram-negative and gram-positive bacteria, especially effective against Staphylococcus aureus. Therefore, Claminat is used in the treatment of respiratory tract infections, skin and soft tissue infections, urinary tract infections,...
2. Indications and contraindications for Claminat 500mg
Claminat 500mg medicine is used in the following cases:Upper respiratory tract infections such as: nasopharyngitis, sinusitis, otitis media, tonsillitis. Lower respiratory tract infections: Exacerbation of chronic bronchitis, lobar pneumonia, bronchopneumonia. Genitourinary tract infections: Cystitis, urethritis, pyelonephritis, female genital infections, postpartum infections, abortion. Skin abscess, infectious dermatitis. Oral infections such as oral mucositis, gingivitis,... Bone and joint infections, osteomyelitis. Peptic ulcer disease caused by infection with the bacteria Helicobacter pylori (HP). Endocarditis Prophylaxis: Amoxicillin may be used to prevent bacteremia that may develop to cause endocarditis. Contraindications of Claminat 500mg:
Allergy to penicillin or other beta lactam antibiotics. Cross-allergy to Cephalosporin antibiotics. Patients with a history of jaundice or hepatobiliary dysfunction associated with antibiotics Amoxicillin and clavulanic acid. Patients with severe renal impairment should not use. Avoid use in patients with infectious mononucleosis because of the high risk of rash in these patients if Amoxicillin is used.
3. Dosage and how to use Claminat 500mg
The drug is taken orally, put the powder in a cup and then add water, stir well and drink immediately. Note to increase the tolerance of the drug in the gastrointestinal tract, should be taken at the beginning of a meal (on an empty stomach) for the best absorption of the drug.Dosage of Claminat 500mg:
For adults or children weighing 40kg or more: Mild to moderate infections use 1000mg/125mg (corresponding to 2 sachets/time) and use 2 times a day. Severe infections such as recurrent urinary tract infections, lower respiratory tract infections, use 1000mg/125mg (corresponding to 2 sachets/time) 3 times/day. Children under 12 years of age or weighing less than 40 kg: Doses range from 40 mg Amoxicillin or 5 mg clavulanic acid per kg body weight/day to 80 mg Amoxicillin or 10 mg clavulanic acid per kg body weight/day. Drink 3 times each time 8 hours apart. Note that the dose should not exceed 3000mg / 375mg per day, corresponding to 6 packs / day. Elderly: No dose adjustment is required and can be used as adults. If there are signs of renal impairment, the dose should be adjusted according to the patient's renal impairment. Renal impairment: Adjust dose according to degree of renal impairment.
4. Note when using Claminat 500mg
Pay attention to your close friend's medical history and allergy history before taking the drug. When taking this medicine can cause some side effects such as: Diarrhea, stomach pain, nausea and vomiting, skin rash, itching, hives, difficulty breathing, difficulty swallowing, wheezing, itching and increased secretions. vaginal discharge, yellowing of the skin or eyes. If you see dangerous side effects such as shortness of breath, abdominal pain, swelling of the face, etc., you should contact your doctor immediately. Adhere to the correct dose and time of use, do not arbitrarily increase the dose, stop the drug when the dose is not enough to avoid antibiotic resistance. If there are signs of resistance to this antibiotic such as no response to the drug when used, this antibiotic should not be prescribed. Claminat 500mg drug can interact with some other drugs, so it is important to inform your doctor about any medications you are taking. Some drugs have been shown to interact with this drug such as antihypertensive drugs Nifedipine, Methotrexate, Allopurinol, oral contraceptives,... During pregnancy, Claminat 500mg may cause adverse effects on the fetus. children, the drug should be avoided during pregnancy. Breastfeeding women when taking the drug is excreted in breast milk, so when using it, it is necessary to consider to avoid the risk of harm to the nursing infant. Store the medicine in a dry place, below 30 degrees, away from direct light and out of the reach of small children. Claminat 500mg is a broad-spectrum antibiotic, widely used and can be used for many subjects when infected. However, this is an antibiotic that should be used under a doctor's prescription, not indiscriminately used to avoid the risk of harm to the body and antibiotic resistance.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
