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Currently on the market there are many drugs to treat cancer, Citafine 1g drug belongs to the group of cancer drugs. Let's find out more clearly how Citafine 1g works, how to use it, in what cases, ... Knowing this information is also a way to use the drug safely.1. What is Citafine 1g?
Citafine 1g belongs to the group of anti-cancer drugs, anti-metabolites, used according to the doctor's prescription. Citafine 1g is manufactured by Emcure Pharmaceuticals Ltd. (India)Main ingredients of Citafine 1g include:
Gemcitabin; Mannitol; Sodium Acetate Trihydrate; Sodium Hydroxide; Hydrochloric Acid. The drug is packaged in a cardboard box, each box contains 1 vial, inside is a drug prepared in the form of a dry powder for injection. Citafine 1g is sold by prescription at pharmacies, hospitals, and specialized clinics nationwide. The selling price depends on the unit.
2. Uses and indications of Citafine 1g
Citafine 1g contains Gemcitabin that is specific to the cell cycle, especially cells in the process of DNA synthesis. Along with that, it also helps inhibit cell growth across the boundary of the G1/S period.The drug Citafine 1g is indicated in cases of cancer such as:
Breast cancer; Ovarian Cancer; Lung cancer; Pancreatic cancer; Bladder cancer. In other forms of cancer, use only when prescribed by a doctor. Patients absolutely do not arbitrarily use.
3. How to use – dose of Citafine 1g
What are the effects of Citafine 1g? This is a drug that supports cancer treatment, used by intravenous infusion under the direction and monitoring of doctors and nurses. Citafine 1g drug can be used in combination with some other drugs in the treatment of each specific form of cancer.Specific dosage of Citafine 1g is as follows:
Citafine 1g dose for pancreatic cancer: In case of pancreatic cancer The recommended dose of Citafine 1g is 100mg/m2 body. Intravenous infusion over 30 minutes in room 1 week. Or it can be used until toxicity is enough to reduce the dose or stop the drug. Take a week off, then use it once a week for 3 weeks, then stop at the 4th week. Dosage of Citafine 1g for lung cancer: Citafine 1g is used for non-small cell lung cancer. Dosage 1000mg/m2 body on days 1, 8 and 15. Treatment regimen within 4 weeks/course. In addition, with the 3-week regimen/course, use 1000mg/m2 body on day 1 and day 8. Used in combination with Cisplatin at a dose of 75-100 mg/m2 body, used every 3 weeks. Dosage of Citafine 1g for breast cancer: 21-day course, intravenous infusion of Paclitaxel (175 mg/m2 body) on the first day for 3 hours. Then use intravenous infusion 1250mg/m2 body within 30 minutes on day 1 and day 8. Before taking Citafine 1g, it is necessary to do a blood count test. Dosage of Citafine 1g with ovarian cancer patients: 21-day course, intravenous infusion of 1250mg/m2 body within 30 minutes on days 1, 8. Carboplatin is infused on day 1, after taking Citafine 1g. Check the patient's blood count before administering the drug. Citafine 1g treatment course for bladder cancer patients: 28-day course, intravenous infusion of 1000mg/m2 body within 30 minutes on days 1.8 and 15. Combined dose with Cisplatin 70 mg/m2 body on day 1 or 2 of a 28-day course.
4. Contraindications Citafine 1g
The drug Citafine 1g should not be used in cases of allergy to any of the ingredients in the drug.5. Precautions and notes when using Citafine 1g
Some cautions when taking Citafine 1g should be noted:Elderly people should reduce the dose to reduce drug clearance; For subjects with liver failure can make the disease worse; Patients with renal failure when using need to monitor blood counts, platelets before use; Determine the parameters of liver and kidney function before use; Electrolyte monitoring when combined with Cisplatin; The longer the use time, the higher the number of uses, the higher the toxicity; Drivers and machine operators should be cautious when using them because they may cause drowsiness and drowsiness; To ensure safety, it is necessary to pay close attention and pay attention to the above points.
6. Take Citafine 1g during pregnancy and lactation
Citafine 1g is not for pregnant women. If used, the patient should be informed of the risk to the fetus. Experimental research shows that Citafine 1g drug has a risk of causing pregnancy malformations, stillbirth,... During the use of Citafine 1g if breastfeeding, it is necessary to consider the risks.7. Side effects when using Citafine 1g
The drug is mainly used in the treatment of various forms of cancer. During use, patients may experience side effects, typically:Anemia, leukopenia or thrombocytopenia; Hemorrhagic spots or slight blood loss; Nausea, vomiting, diarrhea, stomatitis; Fever, erythema, edema; Flu-like symptoms, fatigue, cough, muscle aches, fatigue, weakness,...; Hair Vibration; Hypertension, myocardial infarction, often occurs in subjects with a history of cardiovascular disease; Inform your doctor about unwanted side effects for advice and treatment.
8. Drug interactions Citafine 1g
Citafine 1g drug may interact with some other drugs, including:Increased concentration/effect when used with vaccines, natlizumab, fluorouracil,...; Reduced concentration/effectiveness of vitamin K antagonists; Increased sensitivity to radiation leading to dangerous side effects (in patients with non-small cell lung cancer); ... It is necessary to inform the doctor of all drugs currently or recently used when prescribed Citafine 1g.
8. Preservation of Citafine 1g
Citafine 1g is stored at a temperature not exceeding 25 degrees. The solution after reconstitution can be stored for 1 week at a temperature of 23 degrees. However, it is recommended that the drug should be used up within 24 hours. Do not store the medicine in the refrigerator because it can cause precipitation, affecting the intravenous infusion process.Citafine 1g is a prescription drug, used in the treatment of cancer. In the process of using there are certain interactions and side effects, so it is necessary to be very careful.
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