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Cifga is an antibiotic, often indicated for the treatment of bacterial infections such as urinary tract infections, prostatitis, osteomyelitis - myelitis, severe bacterial enteritis, bacteremia and to help prevent prevention of meningococcal disease and bacterial infections in immunocompromised people.
1. What is Cifga?
Cifga medicine has the main ingredient Ciprofloxacin 500mg, which is made in the form of long film-coated tablets.
Cifga with the main active ingredient is ciprofloxacin, this is a semi-synthetic, broad-spectrum antibiotic, belonging to the Quinolone group, also known as the group of DNA gyrase inhibitors. By inhibiting the enzyme DNA gyrase, the drug prevents the replication of chromosomes, preventing bacteria from reproducing as quickly. Because of this specific mechanism of action of ciprofloxacin, this drug is not subject to parallel resistance to other antibiotics not belonging to the gyrase inhibitor class. Therefore, Ciprofloxacin is highly effective against bacteria that are resistant to antibiotics such as Aminoglycosides, Penicillins, Cephalosporins, Tetracyclines and some other antibiotics.
2. Effects of the drug Cifga
Cifga drug has the effect of killing bacteria and is indicated for use in the following cases:
Treatment of urinary tract infections, prostatitis, osteomyelitis, severe bacterial enteritis, sepsis . Used to prevent meningococcal disease and bacterial infections in immunocompromised people. Cifga is contraindicated in the following cases:
Ciprofloxacin is not indicated in cases of hypersensitivity to ciprofloxacin or other quinolones. Ciprofloxacin is not indicated for children, growing adolescents, and people under 18 years of age. Pregnant or lactating women, as there is no information on the safety of the drug in this patient population.
3. Dosage and usage of Cifga
How to use: Cifga is made in the form of film-coated tablets that should be taken orally. The medicine should be taken with plenty of water while taking the medicine. Take the medicine about 2 hours after a meal.
Dosage: Depending on the case, the dose of the drug is different. Duration of taking the drug from 5 to 14 days depending on the case.
Mild to moderate infections: Take the drug from 250 - 500mg, 2 times a day. Severe infections and complicated infections: Use at a dose of 750mg, twice a day. Use 5 from 10 days. Renal impairment: Creatinine clearance 30 - 50 mL/min orally 250 to 500 mg/12 h. Renal impairment with creatinine clearance 5 - 29 mL/min orally 250 - 500 mg/18 hours. On dialysis, 250 to 500 mg/24 hours. Overdose or missed dose:
Overdose: If you have taken a large dose of the drug, it is necessary to consider to apply measures such as vomiting, gastric lavage, diuretic. Patients should be closely monitored and supportive treatment, such as adequate fluid resuscitation, required. Missed dose: If you miss a dose, take this medicine as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
4. Side effects of the drug Cifga
When using Cifga, you may experience unwanted effects, including:
Common side effects:
Nausea and vomiting, diarrhea, abdominal pain. Temporary increase in transaminase levels. Uncommon side effects:
Headache, drug fever, eosinophilia, anemia and thrombocytopenia. Fast heart beat . Rash, itching. Superficial phlebitis. Pain in the joints and swelling of the joints. Rare side effects:
Anaphylactic or anaphylactoid reactions. Hemolytic anemia, leukocytosis, thrombocytosis, altered prothrombin levels, insomnia, depression, and self-harm. Visual disturbances, hearing disturbances, taste disturbances and olfactory disturbances. Pseudomembranous colitis. Allergic skin-mucosal syndrome, Lyell's syndrome, erythema multiforme. Hepatitis, cholestatic jaundice. Muscle pain, tendinitis is common in the heel tendon and surrounding tissue. Renal failure, interstitial nephritis. Sensitivity to light from sun exposure or UV exposure, shortness of breath, bronchospasm. When experiencing side effects of the drug, you need to stop using it and notify your doctor or go to the nearest medical facility for timely treatment.
5. Notes when using Cifga
Before using the drug, you need to tell your doctor about your history of allergies and medical conditions. So that your doctor can determine the right medication for you.
When taking medicine, you need to follow the doctor's instructions, do not change the dose by yourself because it causes drug resistance or increases the side effects of the drug.
Precautions for use:
Caution should be taken when using ciprofloxacin for people with a history of epilepsy or central nervous system dysfunction, people with impaired liver or kidney function, people with glucose 6 phosphate deficiency. dehydrogenase (G6PD), people with myasthenia gravis. Ability to drive and use machines: Use caution when driving and operating machinery as it may cause dizziness or lightheadedness. Pregnancy: Ciprofloxacin should be used during pregnancy only in cases of serious life-threatening infections for which there is no alternative antibiotic, requiring the use of fluoroquinolone antibiotics. Lactation: Ciprofloxacin should not be used by nursing mothers, as it accumulates in milk and may reach concentrations harmful to the infant. If the mother must take Ciprofloxacin, then breastfeeding should be discontinued while taking the drug. Long-term use of Ciprofloxacin as well as other antibiotics can make the bacteria insensitive to the drug, the patient must be monitored and the antibiotic map is made when necessary to take appropriate treatment.
Ciprofloxacin may cause tests for bacteria such as Mycobacterium tuberculosis to be false negative.
Due to the possibility of increased sensitivity to sunlight, you should limit sun exposure when using or take appropriate protective measures when using the drug.
6. Drug interactions
Some drugs that can cause interactions with Cifga include:
Concurrent use of non-steroidal anti-inflammatory drugs (Ibuprofen, Indomethacin, ...) will increase the risk of side effects of Ciprofloxacin. Concomitant administration of antacids containing aluminum and magnesium will decrease serum concentrations and reduce the bioavailability of ciprofloxacin. Ciprofloxacin should not be taken concurrently with gastric antacids that need to be taken apart from each other (antacids should be taken 2-4 hours before taking Ciprofloxacin). The absorption of the antibiotic ciprofloxacin can be reduced by half if you take it concomitantly with some cytotoxic drugs such as Cyclophosphamide, Doxorubicin, Cytosin Arabinoside, Vincristin, Mitozantrone. Concomitant administration of Didanosine resulted in a significant decrease in blood levels of Ciprofloxacin. Ciprofloxacin should be taken 2 hours before taking Didanosine or after 6 hours. Preparations containing iron (fumarat, gluconate, sulfate) or zinc significantly reduce the intestinal absorption of ciprofloxacin, while zinc preparations have less effect. Avoid concomitant administration of the antibiotic Ciprofloxacin with iron or zinc preparations or take them as far apart as possible. Sucralfate reduces absorption of Ciprofloxacin: Antibiotics should be given 2 to 6 hours before taking Sucralfate. Ciprofloxacin increases serum theophylline concentrations when administered concomitantly. Blood levels of theophylline should be checked and dose reduction may be necessary if two drugs are required. Concomitant administration of ciprofloxacip and ciclosporin may cause a transient increase in serum creatinine. Blood creatinine should be checked twice a week with the drug, if prolonged. Probenecid reduces the glomerular filtration rate and reduces the renal tubular secretion of the antibiotic Ciprofloxacin, thereby reducing the urinary excretion of the drug and increasing side effects. Ciprofloxacin increases the activity of the anticoagulant Warfarin when co-administered. Blood prothrombin levels should be checked regularly and the dose of anticoagulants should be adjusted. Storage: The drug should be stored in a dry place, at a temperature not exceeding 300C, protected from light. Keep out of reach of children.
In short, the antibiotic Cifga is used under a doctor's prescription. Patients do not arbitrarily use to avoid the risk of harm to the body and the risk of drug resistance.
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