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Cifataze DT 100 is prepared in the form of uncoated dispersible tablets, with the main ingredient being Cefixime trihydrate. Medicines are used to treat various bacterial infections.
1. Uses of Cifataze DT 100
Cifataze DT 100 has the main ingredient is Cefixime trihydrate 100mg. Cefixime trihydrate is a 3rd generation cephalosporin antibiotic with bactericidal activity in cases of bacterial infections. Mechanism of action: The drug binds to the target proteins, inhibits the synthesis of Mucopeptides on the bacterial cell membrane, changes the permeability of the membrane and leads to the death of the bacteria. The spectrum of action of the drug against both gram-negative and gram-positive bacteria.
Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many microorganisms that are susceptible to penicillins and to some cephalosporins due to the absence of beta-lactamases may still be susceptible to Cefixime.
Indications to use Cifataze DT 100:
Treatment of uncomplicated urinary tract infections; Treatment of otitis media; Treatment of tonsillitis and pharyngitis; Treatment of dysentery, typhoid; Treatment of gonorrhea; Treatment of acute and chronic bronchitis; Treatment of community-acquired pneumonia: Mild and moderate form. Contraindications to the use of Cifataze DT 100: People who are allergic to Cefixime, Cephalosporin antibiotics or other ingredients in the drug.
2. How to use and dose Cifataze DT 100
Usage: Orally. The tablet should be put in a small cup of water (5 - 10ml of water), gently stirred to disperse the tablet and then drink it immediately.
Dosage:
Dosage in adults:
Usual dose: 400mg/day, divided into 1-2 times (each time 12 hours apart); Treatment of uncomplicated gonorrhea: 400mg once and in combination with another antibiotic. There are some cases where patients can take doses above 800mg/time; Treatment of disseminated gonorrhea: 400mg/time x 2 times/day for 7 days. Dosage in children:
Children over 12 years old or over 50kg: Use the same dose as adults; Children over 6 months - 12 years old: Use dose of 8mg/kg/day, 1-2 times/day. Duration of treatment: Extend 48 - 72 hours after the symptoms are gone:
Uncomplicated upper respiratory tract infections, urinary tract infections: Use at least 5-10 days (10 days for rheumatic heart disease prevention); Lower respiratory tract infections or otitis media: Use 10-14 days. Dosage for patients with renal failure:
Creatinine clearance above 60ml/min: No dose adjustment is required; Creatinine clearance 21 - 60ml/min: Use 300mg/day; Creatinine clearance less than 20ml/min: 200mg/day. Missed dose: When forgetting a dose of Cifataze DT 100, the patient should take it as soon as he remembers. However, if it is almost time for the next dose, the patient should skip the missed dose.
Overdose: When taking too much Cifataze DT 100, patients may have convulsions or other side effects. Patients should go to the hospital immediately for timely treatment.
3. Side effects of Cifataze DT 100
Some side effects patients may encounter when using Cifataze DT 100 include:
Central nervous system: Dizziness, headache, seizures; Dermatology: Stevens-Johnson syndrome, facial edema, urticaria, skin rash, erythema multiforme, toxic epidermal necrolysis; Gastrointestinal: Loose stools or frequent defecation, diarrhea, dyspepsia, abdominal bloating, abdominal pain, vomiting, nausea, pseudomembranous colitis; Genitourinary-urinary: Candida infection, transient increase in BUN and creatinine, acute renal failure, vaginitis, genital itching; Hematology and lymphatic system: eosinophilia, neutropenia, agranulocytosis, pancytopenia, prolongation of prothrombin time; Liver: Hepatitis, jaundice, increased AST and ALT, transient elevation of alkaline phosphatase; Hypersensitivity: Fever, angioedema, serum sickness-like reactions, anaphylactic reactions.
4. Be careful when using Cifataze DT 100
Some notes that patients need to remember before and while using Cifataze DT 100 include:
Pregnant women: There are no adequate studies in humans, only use Cifataze DT 100 when really needed. doctor's permission after careful consideration; Nursing mothers: It is not known whether Cifataze DT 100 is excreted in breast milk or not, so it is necessary to consider temporarily stopping breastfeeding while taking the drug; Use with caution in patients with a history of hypersensitivity to penicillins, cephalosporins or other drugs. There have been cases of cross-reactivity with beta-lactam antibiotics. When a patient experiences a reaction to cefixime, the drug should be discontinued. Severe acute hypersensitivity reactions may require administration of adrenaline or other emergency measures (including intravenous infusion, intravenous administration of antihistamines, corticosteroids, or vasoconstricting amines), and monitoring of glucose levels. breathing according to clinical indications; Cifataze DT 100 can mutate common bacteria in the colon, causing Clotridia to overgrow. The toxin produced by this strain is the primary cause of severe antibiotic-associated diarrhea, including pseudomembranous colitis. Symptoms of pseudomembranous colitis can range from mild to life-threatening. In moderate and severe cases, emergency fluids, electrolytes, and protein supplementation are recommended. If the colitis does not improve, take vancomycin; When prescribing Cifataze DT 100, if a prophylactic infection is suspected, there may be an increased risk of developing resistant bacteria; When using Cifataze, there is a possibility of the emergence of resistant microorganisms, especially if the treatment is long-term. At that time, the patient should be carefully observed, if there is superinfection, appropriate treatment measures should be taken; The dose of cefixime should be adjusted in patients with renal failure and those on continuous outpatient peritoneal dialysis and hemodialysis. Should monitor the patient's health on dialysis; Use caution when using Cifataze DT 100 in people with a history of gastrointestinal disease.
5. Cifataze DT 100 drug interactions
Some drug interactions of Cifataze DT 100 include:
Using Cifataze DT 100 at the same time with Carbamazepine may increase the concentration of Carbamazepine, so it is necessary to monitor the concentration of this substance in plasma; Cifataze DT 100 when used concurrently with anticoagulants will increase Prothrombin time, with or without bleeding clinically; Cifataze DT 100 may interact with laboratory tests: False-positive reactions to ketones in the urine have been observed with tests using nitroprusside. Administration of cefixime can also cause a false-positive reaction for glucose in the urine if clintest is used with Benedict or Fehling's solutions. To be on the safe side, patients should inform their doctor about any medications they are taking and any medical conditions they have. At the same time, patients should strictly follow the doctor's instructions when using Cifataze DT 100 if they want to ensure the best treatment effect and reduce the risk of unpredictable side effects.
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