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Cezirnate is an antibiotic indicated in mild to moderate infections of the lower respiratory tract such as sinusitis, otitis media, pharyngitis, ... To limit the risk of side effects, you need to take the drug according to the instructions. directed by Doctor.
1. What is Cezirnate?
Cezirnate contains the main ingredient Cefuroxim, which is a 2nd generation Cephalosporin antibiotic. The drug has good bactericidal effect on Gram-negative bacteria lines such as Enterobacter, Escherichia coli, Klebsiella, Neisseria, Haemophilus Influenzae; Gram-positive cocci;...
Cefuroxime component works by inhibiting bacterial cell wall synthesis by binding to essential proteins, thereby preventing bacteria from multiplying.
After oral administration, Cezirnate is rapidly absorbed from the gastrointestinal tract and is hydrolyzed in the intestinal mucosa and released into the systemic circulation. The drug can pass through cerebrospinal fluid, placenta and breast milk. Finally, the drug is excreted unchanged in the urinary tract.
2. Indications of the drug Cezirnate
Cezirnate is indicated for use in the following cases:
Otitis media; Tonsillitis ; Recurrent sinusitis; Sore throat; Acute bronchitis with superinfection; Community-acquired pneumonia ; Urinary tract infections: urethritis, cystitis,...; Cervicitis, acute gonorrhea urethritis; Nail boils, impetigo, pustular dermatitis.
3. Contraindications of the drug Cezirnate
Cezirnate is not contraindicated in patients who are allergic to the Cefuroxime component of the drug or to any drug of the Cephalosporin group of antibiotics.
4. Cezirnate drug interactions
Use of high doses of Probenecid increases the concentration of Cezirnate in the blood. Aminoglycoside antibiotics or potent diuretics (such as furosemide) when co-administered with Cezirnate may increase nephrotoxicity. Cezirnate may affect the intestinal microflora Cezirnate may reduce estrogen reabsorption, thereby reducing the effectiveness of oral contraceptives containing estrogen and progesterone. The combination of Ranitidine, sodium bicarbonate with Cezirnate reduces the bactericidal effect of the drug. Antacids or H2 blockers should be administered 2 hours after taking Cezirnate due to an increase in gastric pH. Cezirnate is not indicated for patients being treated with penicillin.
5. Dosage and usage
How to use:
Take the pill whole, do not crush the medicine. Take the medicine with meals to increase the effect. Dosage:
Respiratory tract infections: 1-2 tablets x 2 times/day. Use for 7-10 days. New Lyme disease: Take 2 tablets x 2 times/day. Use for 20 days. Uncomplicated gonorrhea: Take a single dose of 4 tablets (250mg tablets). Children with respiratory tract infections: Dose of 20mg/kg/day (maximum 500mg/day) divided into 2 oral doses/day. Use for 7-10 days. Patients with renal failure undergoing dialysis: Maximum dose 1g/day.
6. Side effects of the drug Cezirnate
When treated with Cezirnate, some unwanted side effects may occur:
Common side effects
Diarrhea; Erythema, erythematous, pruritic rash. Uncommon side effects
Anaphylactic reactions; Candida infection of the oropharynx; Eosinophilia, neutropenia, positive Coomb's test; Nausea, vomiting; Get angry. Rare side effects
Pseudomembranous colitis; headache, convulsions, agitation; Joint pain; Steven-Johnson syndrome ; Hemolytic anemia; Increased liver enzymes; Acute renal failure, interstitial nephritis; Bacterial, fungal infections of the vagina.
7. Precautions when using Cezirnate
Patients with a history of allergy to beta-lactams when forced to take the drug should be cautious; Diuretics when taken with Cezirnate may affect kidney function; Cezirnate long-term treatment causes drug resistance in susceptible strains of bacteria; The drug crosses the placenta and breast milk, so the benefit of taking the drug in pregnant and lactating women should be considered. Thus, Cezirnate is an antibiotic with bactericidal effect on many susceptible strains of bacteria. The drug has a broad antibacterial spectrum, so it is widely indicated in respiratory, urinary, and genitourinary infections. However, to avoid drug resistance, it is necessary to use the drug according to the dose and duration prescribed by the doctor.
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