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Cefxl 200 has an antibiotic as the main active ingredient, which is indicated for the treatment of diseases caused by bacteria. To use it effectively and safely, you need to understand the uses and precautions when using Cefxl 200.
1. What are the effects of Cefxl 200?
The main ingredient of Cefxl 200 is the antibiotic Cefpodoxime 200mg, prepared in the form of film-coated tablets.
Cefpodoxime is an antibiotic belonging to the 3rd generation Cephalosporin group, which is highly stable against the attack of beta-lactamase enzymes produced by gram-negative and gram-positive bacteria. The antibacterial action of Cefpodoxime is obtained through inhibition of bacterial cell wall synthesis by acylation of membrane-bound transpeptidase enzymes, which prevents cross-linking of peptidoglycan chains essential for cell wall repair. Bacterial cells maintain a certain strength and durability.
Cefpodoxime is active against most gram-positive and gram-negative bacteria. The antibacterial spectrum of this antibiotic against gram-positive bacteria includes bacteria such as Staphylococcus aureus with the exception of methicillin-resistant Staphylococci, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus spp. Cefpodoxime-susceptible Gram-negative bacteria include beta-lactamase-producing and non-beta-lactamase-producing strains of H. influenzae, H. para-influenzae, Moraxella catarrhalis, Neisseria meningitidis, Neisseria gonorrhoeae, E. .coli, Proteus vulgaris, Klebsiella pneumoniae, Providencia rettgeri and Citrobacter diversus.
The drug Cefxl 200 works on most types of gram-negative and gram-positive bacteria. Some indications of antibiotic Cefxl 200 to treat bacterial infections include:
Upper respiratory tract infections including: acute otitis media, rhinosinusitis, tonsillitis, pharyngitis, acute VA. Community-acquired acute pneumonia, acute bronchitis. Acute gonococcal infection has not caused complications. Uncomplicated urinary tract infections. Skin and skin structure infections.
2. Dosage and how to use Cefxl 200
How to use: The drug is taken orally with plenty of water. This medicine should be taken with food.
Dosage in adults:
Upper respiratory tract infections including tonsillitis, sinusitis and nasopharyngitis: 100mg every 12 hours for 10 days. Community Acquired Acute Pneumonia: Higher dose of 200 mg every 12 hours for 14 days. Uncomplicated acute gonococcal infection: Use a single Cefxd 200 tablet. Uncomplicated urinary tract infections: 100mg every 12 hours for 7 days. Skin and skin structure infections: 400mg (2 Cefxd 200 tablets) every 12 hours for 7-14 days. Children:
Acute otitis media: Oral at a dose of 10 mg/kg/day (maximum not more than 400mg/day in 2 divided doses) within 10 days. Pharyngitis and tonsillitis: Use at a dose of 10mgkg/day (maximum not more than 200mg/day divided into 2 divided doses) within 10 days. Renal Impairment:
For patients with severe renal impairment (creatinine clearance less than 30ml/min), the dose interval change should be increased to 24 hours. Elderly:
Use dose based on renal function. Hepatic impairment:
No dose adjustment of Cefxd 200 is required in patients with hepatic impairment. Missed dose and overdose:
Missed dose: If you forget to take a dose, take it as soon as possible. However, if it is too close to the next dose, skip the missed dose. Try not to forget to take your medicine as it can reduce the bacteria-killing effect of the antibiotic. Overdose: When taking an overdose of the drug than prescribed by the manufacturer, you should immediately go to a medical facility for timely treatment and supportive treatment.
3. Contraindications to using Cefxl 200
Cefxl 200 should not be used in the following cases:
Cefxl 200 is not indicated in patients with a history of hypersensitivity to Cefpodoxime. Use with caution because of possible cross-allergic reactions with cephalosporins or other penicillins.
4. Side effects when using Cefxl 200
Side effects of Cefxl 200 reported in clinical trials are usually quite mild and transient, rarely affecting drug use. Side effects include:
Diarrhea, nausea and vomiting, abdominal pain, pseudomembranous colitis; headache. Rarely, hypersensitivity reactions such as rash, skin pruritus, dizziness; Thrombocytopenia or thrombocytopenia, decreased or increased eosinophils also occasionally occur. You may also experience other side effects while taking this medicine. If when using Cefxl 200, there are side effects that make you feel worried, please notify your doctor immediately for advice or go to the nearest medical facility for treatment.
5. Things to keep in mind when using Cefxl 200
Cefxl 200 antibiotic is a prescription drug, only used when prescribed by a doctor. This medicine is only effective against bacterial infections, not viruses. Before use, inform your doctor about any allergies. When using the drug, it is necessary to think of pseudomembranous colitis in patients with persistent diarrhea after taking Cefxl 200. When this symptom is found, it is necessary to initiate treatment with appropriate antibiotics. Do not arbitrarily use the drug or change the dose, use, or stop using it without the consent of the doctor. As with other antibiotics, prolonged use may increase the risk of infection caused by bacteria that are not sensitive to this antibiotic. Alteration of laboratory values: Cephalosporins administration of antibiotics may cause a false-positive direct Coomb test. Precautions:
Particular caution should be exercised in patients who have experienced symptoms of anaphylaxis to penicillin. Ideally, cefpodoxime should not be used in patients with a history of sensitivity to cephalosporins or other beta-lactam antibiotics. For pregnant women: Studies have been conducted in a variety of experimental animals and have not shown any teratogenic or fetotoxic effects; Although it is possible to prescribe cefpodoxime for pregnant women, it should only be used when absolutely necessary. Lactation: Due to the serious and dangerous reactions that the drug may cause in the nursing infant, a careful decision should be made between whether to discontinue nursing or to discontinue the drug. Elderly people: Because elderly people often have reduced kidney function, it is necessary to pay attention to kidney function when using.
6. Drug interactions
Some drugs that can cause interactions when co-administered with Cefxl 200 include:
Peak plasma concentrations are reduced by about 30% when Cefxl 200 is used together with antacids or H2 inhibitors. Therefore, these drugs need to be taken at least 2 hours apart. When concurrent use of Cefpodoxime with nephrotoxic compounds is indicated, close monitoring is recommended. Cefpodoxime plasma concentrations are increased when co-administered with Probenecid. Storage: Store the medicine in a dry place, below 25 degrees Celsius, away from direct light and moisture. Keep out of reach of CHILDREN. Do not use if there are signs of damage and expiry date.
Above is information about the uses, usage and notes of Cefxl 200. Cefxl is to be taken only under your doctor's prescription, so ask your doctor or pharmacist directly if you have any questions.
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