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Cebest 50mg brand-name drug is often indicated for use in the treatment of mild - moderate bacterial infections, such as skin infections, gonococcal infections,... Before and during the treatment period. With Cebest 50mg, patients need to strictly follow the medication plan recommended by the doctor.
1. What is Cebest 50mg?
Cebest 50mg drug is often used to treat and reverse symptoms of bacterial infections, such as skin infections, respiratory infections, gonococcal infections,... Cebest 50mg is a product of the Joint Stock Company. part of Merap Group, is prepared in the form of nuggets mixed with oral suspension, with packaging specifications of 20 packs x 1.5g.
In each packet of Cebest 50mg nuggets, the main active ingredient is Cefpodoxime (in the form of Cefpodoxime proxetil) with a concentration of 50mg and other excipients just enough. This active ingredient belongs to the 3rd generation Cephalosporin group, has antibacterial ability based on the mechanism of preventing bacterial cell wall synthesis by acylation of membrane-bound transpeptidase enzyme. This effect also helps inhibit the cross-linking of peptidoglycan chains, which are important for the strength and strength of the bacterial cell wall.
The active ingredient Cefpodoxime in the drug Cebest 50mg has the ability to fight both Gram-positive and negative bacteria, such as:
Staphylococcus aureus. β-lactamase-producing strains. H. para-influenzae. Neisseria meningitidis. Providencia rettgeri. Peptostreptococcus spp. Proteus vulgaris. Neisseria gonorrhoeae. E. Coli . Citrobacter diversus.
2. Indications and contraindications to the use of Cebest 50mg
2.1 Indications for use of Cebest 50mg Drug Cebest 50mg is usually indicated for use in cases of mild to moderate infections caused by susceptible strains of bacteria, including:
Bacterial infections lower respiratory tract, such as community-acquired pneumonia; acute exacerbation of chronic bronchitis caused by H. influenzae or S. pneumoniae. Upper respiratory tract infections, such as acute otitis media caused by Moraxella (Branhamella) catarrhalis or Streptococcus pneumoniae; acute maxillary sinusitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis; pharyngitis/tonsillitis caused by Streptococcus pyogenes. Genital tract infections such as uncomplicated cervical/urethral gonorrhea, acute gonorrhea caused by Neisseria gonorrhoeae, acute anorectal infections caused by Neisseria gonorrhoeae. Skin and tissue infections caused by Streptococcus pyogenes or Staphylococcus aureus (including penicillinase-producing strains) Uncomplicated urinary tract infections (cystitis) caused by Proteus mirabilis, Escherichia coli, Staphylococcus saprophyticus or Klebsiella pneumoniae. 2.2 Contraindications of the drug Cebest 50mg Do not use Cebest 50mg for the following subjects:
Patients with hypersensitivity or history of allergy to Cefpodoxime, other Cephalosporins or any of the excipients in the drug. Do not use Cebest 50mg for people with hypersensitivity to antibiotics of the Beta lactam or Penicillin family. Relative contraindications Cebest 50mg for pregnant women, planning to become pregnant or breastfeeding.
3. Dosage and how to use Cebest 50mg
3.1 Dosage of Cebest 50mg Dosage for children > 12 years old & adults:
Take a dose of 100-400mg x 2 times / day, each dose is 12 hours apart. Dosage for treatment of acute exacerbation of chronic bronchitis or mild - moderate pneumonia in the community: Oral 200mg x 2 times / day, each dose is 12 hours apart, maintained for 10-14 days. Dose to treat tonsillitis or pharyngitis caused by Streptococcus pyogenes infection: Oral 100mg x 2 times / day, each dose is 12 hours apart, maintained for 5 - 10 days. Dosage for treatment of mild - moderate uncomplicated skin/skin structure infections: Oral 400mg x 2 times/day, each dose is 12 hours apart and maintained for 1-2 weeks. Treatment of uncomplicated urinary tract infections: Oral 100mg x 2 times / day, each dose is 12 hours apart and used for 1 week. Treatment of uncomplicated gonorrhea: Single oral dose of 200mg or 400mg, followed by oral doxycycline treatment to prevent Chlamydia infection. Dose for children from 2 months to 12 years old:
Usual recommended dose: Oral 10mg/kg body weight/day, divided into 2 times/day, taken 12 hours apart. Drink up to 400 dong/day. Treatment of acute otitis media: Oral 5mg/kg, divided into 2 times/day, each dose 12 hours apart and administered for 5 days. Treatment of tonsillitis or pharyngitis: Take 5mg / kg, divided into 2 times / day and about 12 hours apart, orally within 5 - 10 days. Treatment of acute sinusitis: Oral 5mg/kg, divided into 2 times/day and taken within 10 days. Treatment of community-acquired acute pneumonia: Oral 200mg, divided into 2 times / day and used within 10-14 days. Treatment of uncomplicated urinary tract infections: Oral 100mg, divided into 2 times / day and maintained for a week. 3.2 Instructions for effective use of the drug Cebest 50mg Cebest 50mg drug is prepared in the form of granules mixed with oral suspension, so patients can use the drug orally according to the dosage recommended by the doctor. In all cases, Cebest 50mg drug is only allowed to be used when prescribed by a doctor, so patients should avoid self-medicating or adjusting the dose not according to instructions. This can have many potential health hazards.
4. Possible side effects when treating infections with Cebest 50mg
Below are some adverse effects that patients are at risk of experiencing while taking Cebest 50mg:
Hematologic disorders (thrombocytopenia, decreased hemoglobin, leukopenia, thrombocytopenia, leukopenia). eosinophils) or hemolytic anemia. Neurological symptoms such as dizziness, unusual sensations or headache (uncommon). There are some abnormalities in the ear, such as tinnitus and hearing disorders. Common gastrointestinal symptoms after taking Cebest 50mg, including nausea, increased stomach pressure, vomiting, flatulence, diarrhea, abdominal pain, bloody diarrhea (related to enteritis) , pseudomembranous colitis. Metabolic and nutritional disorders, most commonly loss of appetite. Rarely, immune system disorders have been reported with Cebest 50mg, such as bronchospasm, anaphylactic reactions, angioedema or purpura. Very rarely, symptoms of kidney-urinary disorders, such as mild elevations of creatinine and blood urea nitrogen, have been reported. Rarely, hepatobiliary disorders, including transient elevations in liver enzymes of ALAT, ASAT, bilirubin or alkaline phosphatase; sometimes liver damage. Subcutaneous tissue disorders such as hypersensitivity to skin-mucosal reactions, urticaria, pruritus or skin rash. Very rarely, Johnson Stevens syndrome, erythema multiforme or toxic epidermal necrolysis have been reported. Bacterial or parasitic infections caused by prolonged use of the drug, leading to the uncontrolled growth of non-susceptible strains of bacteria such as Clostridium difficile or Candida. General disorder symptoms, eg malaise or weakness (uncommon). Patients should notify their doctor as soon as possible if they notice the appearance of any of the side effects mentioned above.
5. Important notes when using Cebest 50mg
5.1 Be careful in the process of taking Cebest 50mg During the treatment of mild - moderate infections with Cebest 50mg, you should note a few things as follows:
Active ingredient Cefpodoxime is not preferred to be used to treat conditions staphylococcal pneumonia, and avoid this antibiotic for atypical pneumonia caused by strains of bacteria such as Mycoplasma, Legionella and Chlamydia. Medicines containing Cefpodoxime are not recommended for the treatment of pneumonia caused by strains of S. pneumoniae. When a serious hypersensitivity reaction occurs, the patient should immediately stop treatment with Cebest 50mg and seek appropriate emergency support measures. The patient's history of allergy to beta-lactam antibiotics, penicillin and cefpodoxime, and cephalosporins should be carefully investigated. In patients with severe renal impairment, the dose should be titrated down based on creatinine clearance. Patients with diarrhea symptoms when using Cebest 50mg drug should beware of the risk of pseudomembranous colitis and mild or even life-threatening colitis. Patients with a history of gastrointestinal disease, such as colitis, should be used with extreme caution. Prolonged treatment with Cebest 50mg can reduce white blood cell count. The safety and effectiveness of the drug for children under 2 months of age have not been determined, it is best not to give this drug to this patient population. There is a risk of a false positive for glucose in the urine. Cebest 50mg medicine may affect patients with Phenyl syndrome because it contains Aspartame - Phenylalanine producing factor. 5.2 Drug Interactions The following are drugs that have the potential to interact if combined with Cebest 50mg:
H2 antihistamines, antacids when used with Cebest 50mg may reduce bioavailability. of the active ingredient Cefpodoxime. If it is necessary to take these drugs, the patient should take them 2-3 hours after taking Cebest 50mg. The renal excretion of cefpodoxime may be reduced when administered with Probenecid. Reduces the activity of live typhoid vaccine if used with Cebest 50mg. Increases the effect of Coumarin anticoagulants or reduces the contraceptive effect of estrogen.
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