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Catoprine belongs to the group of anti-cancer drugs and acts on the immune system. Catoprine can cause some unwanted side effects. Therefore, patients need to take Catoprine exactly as prescribed by the doctor.
1. What is Catoprine?
Catoprine is a table A poison, in the form of tablets, packing is a box of 10 blisters x 10 tablets. Catoprine's main ingredient is mercaptopurine. The component mercaptopurine in the drug Catoprine is one of the purine analogues, which has the ability to inhibit nucleic acid biosynthesis. Mercaptopurine competes with guanine and hypoxanthine for the enzyme hypoxanthin-guanine phosphoribosyltransferase (HGPRTase). When absorbed, catoprine is metabolized in cells and becomes a ribonucleotid, which acts as a purine antagonist. As a result, DNA and RNA synthesis is inhibited.
In particular, mercaptopurine is also known to be a strong immunosuppressant. The drug has the ability to strongly suppress the initial immune response, with little effect on suppressing the cellular immune response and selectively inhibiting humoral immunity.
2. Indications of the drug Catoprine
Catoprine is indicated for the treatment of:
Acute leukemias; Sarcomas; Chronic myeloid leukemia ; Autoimmune diseases.
3. Contraindications of the drug Catoprine
Contraindicated to use Catoprine in the following cases:
Women who are breastfeeding; People with severe leukopenia; People who are having thrombocytopenia with bleeding; People with liver damage.
3. Dosage and how to use Catoprine
Usage: Catoprine drug is taken orally.
Dosage:
For adults: From 2-2.5mg/kg/day x 2 times. Each course of treatment with Catoprine is about 3-4 weeks. How to deal with missed dose, overdose of Catoprine:
In case of forgetting a dose of Catoprine, it is advisable to supplement as soon as possible. However, if it is almost time for the next dose, skip the missed dose of Catoprine and use a new dose. Catoprine overdose can cause loss of appetite, diarrhea, nausea or slowness such as liver dysfunction, marrow failure and gastroenteritis. Patients need to stop the drug immediately and go to the nearest medical facility for timely treatment.
4. Undesirable effects of the drug Catoprine
At therapeutic doses, catoprine is well tolerated. However, during the use of Catoprine, patients may still experience side effects such as:
Common: Hyperbilirubinemia, increased GOT, increased alkaline phosphatase, intrahepatic cholestasis, jaundice, hyperuricemia, tissue hyperpigmentation, nausea, diarrhea, anorexia, stomatitis, stomach pain, thrombocytopenia, leukopenia, anemia, mucositis, and nephrotoxicity. Uncommon: Dry skin, drug fever, scaling, tarry stools, glossitis and eosinophilia. If you experience these symptoms, the patient should stop using Catoprine and notify the doctor for appropriate treatment.
5. Catoprine drug interactions
Catoprine may interact with:
Allopurinol; The anticoagulant warfarin. To avoid interactions, before being prescribed Catoprine, the patient should inform the doctor about the drugs they are using, including functional foods. The doctor will base on that to prescribe the appropriate Catoprine.
6. Be careful when taking the drug Catoprine
Patients should only take Catoprine as prescribed by their doctor. Catoprine can cause severe myelosuppression, so the patient's use must be checked regularly. If leukopenia and thrombocytopenia occur, catoprine should be discontinued. Catoprine is potentially hepatotoxic. Therefore, it is necessary to regularly monitor liver function during the use of the drug. Catoprine should be used with caution in pregnant and lactating women. The drug can cause mutations, damage chromosomes in the patient's body. Therefore, caution should be exercised when using Catoprine. Above is all information about Catoprine, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Catoprine treatment at home because there may be unwanted side effects.
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