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What is Candesartan, what disease is it used to treat? What precautions should be taken when using Candesartan? All information surrounding the drug Candesartan will be provided in the article below.
1. Uses of the drug Candesartan
Candesartan is an antihypertensive drug, prescribed by the treating doctor alone or in combination with other drugs to treat patients with hypertension depending on specific conditions. Candesartan has the effect of reducing aortic blood pressure, the effectiveness of reducing blood pressure depends on the dose of medicine prescribed by the doctor in accordance with the patient's blood pressure status.
Treatment of elevated blood pressure with Candesartan reduces mortality and hospitalization for heart failure, a complication of hypertension, as well as improves symptoms in patients with left ventricular systolic dysfunction .
2. Indications for the drug Candesartan
Treatment of hypertension Support treatment of heart failure
3. Contraindications to the drug Candesartan
Patients with allergies, hypersensitivity to the ingredients of the drug Patients with severe liver failure, cholestasis Pregnant and lactating women Should not use the drug in patients with renal failure with serum creatinine concentration ≥ 250 micromol / liter or blood K+ ≥ 5 mmol/liter or Clcr ≤ 30 ml/min.
4. Dosage and how to use Candesartan
Candesartan to treat high blood pressure alone is prescribed by the doctor as follows:
Adult patients, elderly people take 8 mg / time / day Every 4 weeks, if blood pressure is not reduced unsatisfactory and patients can still tolerate the drug is prescribed an increase of 8 mg/day until satisfactory blood pressure reduction or to the maximum dose of Candesartan 32 mg/day (administered 1-2 times). Do not use Candesartan dose > 32 mg/day. If the dose of Candesartan 32mg/day has not been effective, it is necessary to appoint a combination therapy or another drug. At effective doses, blood pressure usually decreases after 2 weeks and maximal reduction after 4-6 weeks. To maintain the dose of Candesartan 8 - 32 mg / day depending on the patient's condition. For patients with hepatic or renal impairment, patients should be started with Candesartan 2mg/day. For patients with renal failure or with intravascular volume depletion, Candesartan 4 mg/day should be used.
Patients with heart failure should be started with Candesartan 4mg/day, and every 2 weeks if there is no response to the drug, the dose should be doubled to a maximum of Candesartan 32mg/day if tolerated. good. However, in the process of using Candesartan to treat hypertension, patients should be closely monitored, especially during the increase in dose.
5. Candesartan side effects
C andesartan is evaluated as an effective antihypertensive drug that responds well to most patients. However, during use, some patients may still face some side effects such as headache, mild dizziness, occasional chest pain, insomnia, fatigue, back pain, muscle pain... Therefore, when using Candesartan, doctors and patients should note the following:
In case the patient has renal artery stenosis, aortic or mitral valve stenosis, muscle hypertrophy Heart should be cautious when taking angiotensin II receptor blockers. Attention should be on good control of blood potassium levels, especially in the elderly, in patients with renal failure, starting with a low dose of Candesartan will be more appropriate for those patients. this statue
6. Subjects need to pay attention when appointing and using Candesartan to treat hypertension
Drivers or machine operators: Candesartan has side effects causing drowsiness, fatigue, dizziness. For subjects that need high concentration, attention should be paid when using antihypertensive drugs. . Pregnant women: It is not recommended to use Candesartan in the first 3 months of pregnancy, especially contraindicated in the second and third trimesters. When pregnancy is diagnosed, it is necessary to stop taking Candesartan and prescribe an alternative antihypertensive therapy appropriate to the medical condition. Candesartan causes major fetal effects such as decreased renal function, oligohydramnios, skull retardation, and is very toxic to the neonate. Therefore, Candesartan is contraindicated in pregnant women. Lactation: It is not recommended to use Candesartan, alternative treatments in lactation, nursing infants, premature babies will be better than Candesartan for both mother and baby. Management of Candesartan Overdosage: If hypotension requires symptomatic treatment, monitor vital signs. The patient should be placed in supine position, legs elevated, plasma volume can be increased by isotonic saline infusion if not effective. Note Candesartan is not removed by hemodialysis. Management of missed dose of Candesartan: The patient should take it as soon as he remembers that he has missed a dose. In case the next dose is missed, skip the missed dose and take the next dose on schedule. Take special care not to take a double dose to make up for the missed dose. Patients treated with high blood pressure with Candesartan need to be very careful about the use, dosage and important information mentioned above. During use, if there is any abnormality, you should immediately contact the treating doctor for timely advice.
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