This is an automatically translated article.
Candekern is a commonly used drug in the treatment of hypertension, which can be used alone or in combination with other antihypertensive drugs to bring the highest effectiveness. Along with that, the drug is also used in the treatment of a number of other diseases as prescribed by a specialist.
1. How does Candekern work?
Candekern is a drug manufactured by Kern Pharma S.L Company of Spain, imported and distributed in Vietnam market by Nhat Anh Pharmaceutical Joint Stock Company.
The main ingredient of the drug is Candesartan cilexetil 16mg, which has the ability to reduce arterial blood pressure by reducing systemic peripheral resistance. At the same time, the use of this treatment also reduces mortality, reduces hospitalization in patients with heart failure, and improves symptoms in patients with left ventricular systolic dysfunction.
2. Indications and contraindications
2.1. Indications Candekern With the above use, Candekern is indicated in the following cases:
Used in the treatment of hypertension. Support the treatment of patients with heart failure. 2.2. Contraindications Candekern drug is contraindicated in the following cases:
People with a history of allergy to any ingredient in the formula of the drug. Candekern should not be used by pregnant or lactating women. Patients with severe liver failure or severe cholestasis. Contraindicated in patients with renal failure with serum creatinine ≥ 250 micromol/liter or blood K+ ≥ 5 mmol/liter or Clcr ≤ 30 ml/min.
3. How to use Candekern
Candekern is a drug that is prepared in tablet form and taken orally. You should take the drug orally with a glass of water after eating with the reference dose as follows:
3.1. For the treatment of hypertension Adults (including the elderly) use a starting dose of 8mg/time/day. After a period of 4 weeks, if blood pressure has not decreased significantly and the patient is still tolerating the drug, then the dose should be increased by 8 mg/day until satisfactory blood pressure reduction is achieved or further increased to a maximum dose of 32 mg/day. (use 1-2 times per day). Do not use Candekern at doses > 32mg/day because higher doses do not increase the effect of the drug. For those who have increased the dose up to 32 mg/day but still no effect, you need to combine therapy or change another drug. If the drug works well, blood pressure usually decreases after 2 weeks and decreases to a maximum after 4-6 weeks. Maintain dose when blood pressure is stable from 8 to 32 mg / day depending on the patient. 3.2. Use in patients with liver failure, renal failure Should start using Candekern at a dose of 2 mg / day. In the case of patients with renal failure or intravascular volume depletion, it is necessary to use a dose of 4 mg / day. 3.3. Use for patients with heart failure When using the drug, patients take Candekern at a dose of 4 mg / time / day. After 2 weeks of taking the drug, if the body does not respond, the dose can be doubled to 32 mg / day. The patient's blood pressure should be checked frequently during dose escalation.
4. Candekern side effects
Although the drug Candekern is well tolerated, but sometimes the drug also causes some side effects to the body such as:
Whole body with signs of weakness, fever. Central and peripheral nervous system, the picture is paresthesia, dizziness. Digestive system disorders with dyspepsia, gastroenteritis. Cardiac arrhythmias include tachycardia, palpitations. Metabolic and nutritional disorders include increased creatine phosphokinase, increased blood sugar, increased triglycerides and increased blood urea. Musculoskeletal disorders cause muscle pain. Coagulation/bleeding/platelet disorders leading to nosebleeds. Nervous disorders include anxiety, neurasthenia, somnolence. Respiratory system disorder with typical symptoms of dyspnea. Skin and skin disorders including rash, profuse sweating. Disturbances of the excretory system such as hematuria. In addition, some other less common symptoms when using Candekern include:
Angina pectoris. Heart attack . Angioedema. Occasionally, patients experience some very rare side effects:
Digestive system with hepatitis and liver dysfunction. The blood system includes neutropenia, leukopenia, and agranulocytosis. Metabolic and nutritional disorders with hyperkalemia, hyponatremia. Kidney includes kidney failure or kidney failure. Skin and soft tissue disorders with typical signs of pruritus and urticaria. After taking the drug, if any allergic reaction occurs, you need to immediately notify the doctor for assistance to overcome.
5. Drug interactions
The use of Candekern with cyclosporin drugs, potassium salts, potassium-sparing diuretics and aldosterone antagonists, diuretics, angiotensin-converting enzyme inhibitors may increase the risk of hyperkalemia or a serious decrease in blood pressure. .
6. What to do in case of overdose or missed dose of Candekern?
In case of overdose, if symptomatic hypotension occurs, treatment should be symptomatic and vital signs monitored. The patient should be placed in supine position, legs elevated, plasma volume increased by infusion as isotonic saline as needed. Note that Candekern is not removed by hemodialysis.
If you miss a dose of Candekern, take it as soon as you remember that you missed the dose. If the missed dose is close to the next dose, skip it instead of taking a double dose to make up for the missed dose
7. Some notes when using Candekern
Caution should be exercised when using the drug in patients with renal artery stenosis. With good control of serum potassium levels, especially in the elderly and in patients with renal impairment, it is best to use a low starting dose in these patients. Caution should be exercised when administering the drug in individuals with aortic or mitral stenosis, and in those with myocardial hypertrophy. Candekern can cause dizziness, drowsiness, fatigue, so do not use while driving or operating machinery. Do not use the drug during pregnancy, if used, it is necessary to closely monitor for hypotension in the neonate. Above is some information about the use of Candekern as well as instructions on how to use the drug properly that readers can refer to. Make sure you take the medicine exactly as directed to get the best results.
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