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The drug Caelyx belongs to the group of anti-cancer drugs. Caelyx contains the active ingredient Doxorubicin HCl with a concentration of 20mg/10ml. So what is Caelyx and how is it used?
1. In what cases is Caelyx used?
Caelyx drug is indicated for use in the following cases:
Indication for treatment of breast cancer in women who have failed treatment with Taxan regimen. Treatment of advanced ovarian cancer in women who have failed platinum-based first-line chemotherapy. Caelyx is indicated in combination with Bortezomib for the treatment of advanced multiple myeloma. Caelyx is used to treat patients with Sacorma Kaposi associated with AIDS and widespread visceral or mucocutaneous disease. Caelyx is contraindicated in the following cases:
Do not use for patients with a history of hypersensitivity to Doxorubicin or any of the excipients of Caelyx. Do not use for pregnant women and nursing mothers. When the patient is being effectively treated with systemic or topical interferon alpha regimens, Caelyx is not indicated for the treatment of AIDS-related Sacorma Kaposi in this case.
2. How to take and dose of Caelyx
2.1. How to take Caelyx
The use of Caelyx should be supervised by a treating doctor. Use Caelyx in intravenous infusion every 4 weeks / 1 time. For a dose less than 90mg, dilute Caelyx with 250ml of 5% Dextrose solution. With a dose of 90mg or more: Dilute Caelyx with 500ml of 5% Dextrose solution. To minimize the risk of infusion-related reactions, the initial dose should be infused at a rate not greater than 1 mg per minute, if no reaction occurs, continue the infusion of Caelyx for 60 minutes. 2.2. Dosage of drugs Caelyx
For breast cancer, ovarian cancer: The starting dose used is 50mg/m2 of the patient's body surface area. The dosing interval is 4 weeks if the patient is not severely ill and tolerating this treatment. For Kaposi sarcoma, the dose used is 20mg/m2 of the patient's body surface area. Dosing interval is from 2 to 3 weeks, lasting for 2-3 months. For multiple myeloma, the dose is 30 mg/m2 body surface area, on the fourth day of each 3-week Bortezomib treatment cycle. In patients with liver problems or certain adverse events that require discontinuation of Caelyx or a dose reduction, it is not recommended for patients who have had their spleen removed.
3. Undesirable effects
During treatment with Caelyx, besides the therapeutic effects, patients also experience unwanted effects depending on the type of cancer.
The most common side effects seen in all cancers are nausea, vomiting, rash, stomatitis, asthenia, palmar erythema, low blood cell count, hair loss, boredom eating, fatigue, constipation, diarrhea, inflammation of the lining of the mouth and throat...
These side effects are usually mild and reversible when Caelyx is discontinued. However, it is recommended that patients when experiencing adverse effects should immediately report to the treating doctor for timely intervention.
4. Drug interactions of the drug Caelyx
There are currently no formal studies or reports of interactions with Caelyx. However, it is inevitable that interactions will occur when used simultaneously with drugs, functional foods as well as other foods. The treating physician should carefully advise the patient to avoid unwanted interactions.
5. Notes when using Caelyx
During treatment with Caelyx, there is a potential for cardiovascular risks, so patients need to have regular ECG examination. Caelyx should be used with caution in patients with impaired cardiac function. There is initial multifactorial bone marrow suppression when the patient is taking Caelyx, caution should be exercised if the patient is taking multiple medications or has pre-existing HIV disease. The patient's blood count should always be checked periodically during treatment with Caelyx. Pay special attention to intravenous infusion-related reactions, features of an allergic or anaphylactoid reaction such as: flushing, asthma, rash, urticaria, fever, chest pain, tachycardia, increased blood pressure,...
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