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Buprine 200 is prepared in the form of an aerosol with the main ingredient being Budesonide. The drug is used in the treatment of a number of respiratory diseases such as asthma, allergic rhinitis, ...
1. What is Buprine 200?
Buprine 200 has the main ingredient is Budesonide 200mcg/dose. Budesonide is a corticosteroid: Inhaled glucocorticoid. Budesonide has obvious anti-allergic, anti-inflammatory and immunosuppressive effects. As with other corticosteroids, budesonide reduces the inflammatory response by reducing prostaglandin synthesis by activating phospholipase A2. Corticosteroids increase the concentration of certain membrane phospholipids that inhibit prostaglandin synthesis. These drugs also increase levels of lipocortin, (a protein that reduces the phospholipid substrates of phospholipase A2). Corticosteroids reduce capillary permeability by inhibiting the activity of kinins and bacterial endotoxins and by reducing the amount of histamine secreted by basophils.
Buprine 200 is used in the following cases:
Use of nasal spray in children and adults for the treatment of year-round or seasonal allergic rhinitis; Inhalation through the mouth for maintenance treatment and prevention of asthma. In many patients, the use of inhaled Buprine 200 reduces the need for oral corticosteroids or may completely replace this medication. Inhaled corticosteroids are effective for acute asthma attacks but require continuous use as a daily prophylactic. Do not use Buprine 200 in case the patient is hypersensitive to Budesonide or to any other ingredient in the medicinal product.
2. Usage and dosage of Buprine 200
Buprine 200 is to be used as directed by your doctor for specific use and dosage.
3. Side effects of Buprine 200
Some side effects patients may encounter when using Buprine 200 are:
Common: Central nervous system: Headache, dizziness, agitation, insomnia, mental changes; Cardiovascular: Heart palpitations; Gastrointestinal - Gastrointestinal: Occurrence of gastric - intestinal irritation, bitter mouth, loss of appetite, appetite, oral candidiasis, dry throat, dry mouth, loss of taste; Respiratory: Cough, bronchitis, hoarseness, upper respiratory tract infections, nosebleeds; Skin: Skin rash, skin itching, acne, urticaria; Endocrine and metabolic: Menstrual cycle disorders; Eyes: Cataracts; Other common side effects: Loss of sense of smell; Uncommon: Digestive system: Abdominal bloating; Respiratory: Shallow breathing, bronchospasm; Endocrine and metabolic: Children with growth retardation, ACTH inhibition. When experiencing side effects of Buprine 200, patients should notify their doctor early to receive advice on the most appropriate treatment and response.
4. Be careful when using Buprine 200
Some notes patients need to remember before and while using Buprine 200 are:
Caution when using Buprine 200 in patients with viral or fungal rhinitis, pulmonary tuberculosis; When a patient is also using an inhaled bronchodilator, it should be administered prior to Buprine 200 to increase the amount of Budesonide that is absorbed into the bronchi. 2 drugs should be used a few minutes apart; After long-term therapy with inhaled budesonide in asthmatics, when the drug is discontinued, bronchial reactivity may return and patients' symptoms may worsen (although one-third of patients Buprine 200 inhalation can be completely stopped without any worsening of symptoms after long-term treatment); A general rule of thumb is to avoid the use of Buprine 200 during pregnancy unless the potential benefits outweigh the possible risks. If corticosteroid therapy during pregnancy cannot be avoided, inhaled corticosteroids should be used because of their low systemic effect; Neonates whose mothers have received significant doses of corticosteroids during pregnancy should be carefully monitored for weight and adrenal insufficiency; There is no information available on the excretion of Budesonide into human milk. Therefore, it is best to stop breastfeeding while the mother is taking Buprine 200; Because Buprine 200 can cause dizziness and headache side effects, it should be used with caution when driving or operating machinery.
5. Buprine 200 . drug interactions
Although to date there have been no reports of drug interactions with Buprine 200, it is thought that Budesonide has the potential to interact with drugs that interact with other corticosteroids such as:
Phenytoin, Barbiturates and rifampicin: Causes sensitization liver enzyme reactions and may increase the metabolism of corticosteroids; Oestrogens may potentiate the effects of hydrocortisone; Anti-inflammatory drugs; Drugs that cause potassium loss may potentiate the potassium-sparing effect of corticosteroids. Patients should inform their doctor about the drugs they are taking before taking Buprine 200 to receive advice and adjust the dose accordingly. At the same time, the patient should not arbitrarily change the dose, route of administration, stop the drug, ... without consulting the doctor.
During the use of Buprine 200, patients should pay attention to listen and follow the instructions from the treating doctor to bring about good therapeutic effects and limit unwanted effects.
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