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Buminate is an infusion containing human Albumin. Therefore, the drug is often used in patients with hypoalbuminemia or hypovolemia due to various causes. So what are the effects of Buminate and what should be noted when using it?
1. What is Buminate?
Buminate drug has the composition of Human Albumin (Albumin Human), prepared in the form of an intravenous solution with 3 concentrations of 5%, 20% and 25%.
2. What effect does Buminate have?
Buminate is used to treat hypovolemia of various causes; Supplementation in people with hypoalbuminemia due to a number of reasons such as insufficient production by the body (including malnutrition, burns, major trauma or infection), excessive breakdown of albumin (from burns, trauma) pancreatitis), loss of albumin from the body (due to bleeding, excessive renal excretion, loss of secretions from burns) or redistribution of albumin (seen during major surgery or due to severe inflammation) ; Buminate is also used to treat hypoalbuminemia in patients with severe trauma, infection or pancreatitis who are unable to recover quickly even though nutritional needs have been met but still have no effect; Buminate In combination with crystalloids to correct hypoosmotic hypoglycemia and replace protein loss due to severe burns in the first 24 hours; Buminate is also used during Cardiopulmonary Bypass Surgery; Buminate 25% is used when hypovolemia persists and hypoalbuminemia is accompanied by fluid or edema. Albumin can be used in combination with certain other drugs (such as diuretics) to treat pulmonary edema and hypoproteinaemia in patients with ARDS. In addition, Buminate 25% is also indicated in the treatment of edema in patients with severe nephrotic syndrome who are taking corticosteroids or diuretics.
Note that Buminate should only be used by trained medical personnel under the direct supervision of the treating physician.
3. What should patients pay attention to before taking Buminate?
When deciding to use a drug, patients need to weigh the possible risks and benefits of the drug. The decision to use medication depends on the outcome of the discussion between the patient and the treating physician.
For Buminate, patients need to consider the following issues:
Possibility of allergies: Patients should inform their doctor about any history of unusual reactions or allergic manifestations when using Albumin. or any other medicine. Also, patients should talk to their doctor about any other allergies, including allergies to foods, dyes, preservatives, or pets; Pediatrics: Reliable studies have shown no difference in the use of Buminate in children compared with adults. However, it is necessary to adjust the dose of the drug in accordance with the child's body weight; Geriatrics: There is no information on the relationship between age and the effects of Buminate when used in elderly patients; Breast-feeding: There are no adequate studies on the use of Buminate in nursing mothers, therefore the potential risks of the drug to the nursing infant have not been established. Therefore, this subject needs to weigh the benefits of treatment against possible risks before deciding to use Buminate; Some other medical problems may affect the use of Buminate, so patients should make sure to tell their doctor treating the following medical problems:
Allergy to N-acetyl-tryptophan or sodium caprylate; Severe anemia; Heart failure with normal or increased cardiac output: Buminate should not be used in patients with this condition; Bleeding problems (eg, internal bleeding); Esophageal varices; Hypertension ; CKD; Pulmonary edema: Buminate should be used with caution.
4. Notes when using Buminate
Buminate should be administered by trained medical personnel by intravenous infusion. An important issue is that the patient must be carefully monitored by the doctor during the infusion to ensure safety, and some blood and urine tests must be performed to detect unwanted effects.
Patients taking Buminate are at risk for serious allergic reactions, especially anaphylaxis, which can be life-threatening and require medical attention as soon as possible. Patients should notify their doctor promptly if they develop symptoms of an allergic reaction such as rash, itchy skin, hoarseness, difficulty breathing or swallowing or any swelling of the hands, face or mouth after taking Buminate. .
The use of Buminate can lead to fluid overload (due to increased blood volume or blood thinning), which in turn leads to overloading of the heart, blood vessels or lungs (pulmonary edema). Patients should notify their doctor immediately if they experience unusual symptoms such as headache, shortness of breath, chest pain or tightness, distended neck veins, lightheadedness or dizziness.
Inform the doctor immediately if the patient has the following symptoms:
Blood in the urine; Blurred vision, changes in the ability to see colors, especially blue or yellow; Chest pain or discomfort; Headache ; Irregular breathing or heart rate; Backache; Nausea; Swelling of the face, fingers, or shins; unusual shortness of breath, tiredness, weakness; Vomiting. Buminate is produced and prepared from donor blood. There is therefore a (albeit very low) risk of transmission of certain viruses to the patient. Blood donors and donated blood are carefully tested to make sure they do not pass the disease on to others.
5. Side effects of Buminate
Besides the therapeutic effects that the drug brings, Buminate can still cause some unwanted effects. Although not all of these side effects will occur, if they do, the patient needs appropriate medical attention.
Patients should contact a doctor or nurse immediately if any of the following side effects occur:
Blue lips, fingernails; Chest tightness; Cough, sometimes with pink foam (due to pulmonary edema); Shortness of breath, rapid breathing, wheezing; Difficulty swallowing; Dizzy; heart palpitations; Rash, itchy skin; Increased sweating; pale skin; Swelling of the eyelids, around the eyes, face, lips, or tongue; Swollen feet and ankles; Chest tightness; Unusual fatigue or weakness. Some other serious side effects of Buminate but the frequency of occurrence have not been determined:
Blurred vision; Chest discomfort; Chills; Psychological panic; Dizziness, fainting, or lightheadedness when changing positions; Fever; Headache; Nausea; Arm, jaw, back, or neck pain; Sweat; Vomiting. Some of the following side effects can occur, which most do not require medical attention, they will usually disappear during treatment as the body adapts to Buminate, including:
Burning sensation; Loss or change in taste; Blushing of face, neck, arms and upper chest. With the above effects of Buminate, the treating doctor can teach the patient how to recognize, prevent or minimize their severity. If the above problems persist or get worse while taking Buminate, the patient should inform the doctor so that it can be resolved.
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