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Binexcadil belongs to the group of cardiovascular drugs, used to treat hypertension and benign tumors. However, users may not understand the dosage and effects of Binexcadil. The following article will summarize the knowledge about the uses and uses of Binexcadil.
1. What is Binexcadil?
Binexcadil is a cardiovascular drug. Drugs used to lower blood pressure and reduce the size of benign tumors. Binexcadil is prepared in the form of tablets, 1 box includes 1 blister, each blister of 10 tablets.
Binexcadil helps reduce blood pressure with the presence of the main active ingredient, Doxazosin. This drug is often used with the effect of blocking the activity of alpha1 - adrenergic receptors. Doxazosin is a derivative of quinazolin. Doxazosin reduces vascular resistance by dilating both arteries and veins. The action of Doxazosin on alpha1-adrenergic receptors is not only in blood vessels but also in muscle tissues containing this receptor.
2. What are the effects of Binexcadil?
Binexcadil drug includes the drug Doxazoxin 2 mg and other excipients enough for one tablet. The effect of this drug in the drug is to block alpha1 - adrenergic receptors at the posterior membrane of the sinape, reducing vasoconstriction, causing increased blood pressure and increased blood pressure.
The mechanism of action of the drug Binexcadil is as follows:
Doxazosin when entering the body will be activated into a drug with properties in the liver, then selectively inhibit alpha1 - adrenergic receptors behind the synaptic membrane. This effect helps to reduce the peripheral resistance in the blood vessel wall, by inhibiting alpha1 receptors in the smooth muscle of the vessels to help dilate the arteries and veins, besides helping to reduce blood flow from the veins to the heart.
Alpha1-adrenergic receptors on other smooth muscles in the body are also subject to the inhibitory effect of Doxatosin. Smooth muscle tissues include the gastro-intestinal sphincter, the basal bladder sphincter, the capsule sphincter of prostate or uterine sphincter, or nonmuscular tissues such as nerves, liver, and kidneys.
Binexcadil can also be prescribed for patients with hypertension and hyperlipidemia. Explain the effect of increasing HDL high-molecular cholesterol and slightly lowering LDL low-molecular cholesterol; Besides reducing total cholesterol and bad blood fat triglycerides.
Doxatosin's inhibition of the contractile effects of muscle tissue with benign prostatic hypertrophy reduces the tone of these organs. The urethral pressure and urinary resistance in the bladder are reduced, helping to reduce urinary obstruction, thereby reducing complications caused by benign prostatic hypertrophy.
Binexcadil is indicated for use in the following cases:
Patients with primary hypertension. Binexcadil can be used alone or in combination with other antihypertensive agents. Patients with benign prostatic hypertrophy The patient should follow the dosage and instructions for using Binexcadil from the doctor.
3. Usage of Binexcadil
3.1. How to use Binexcadil For this drug, patients can use it orally. Take the whole pill, do not break the pill to divide the dose or crush the pill to make it easier to take, as this may cause the medicine to lose its effectiveness.
3.2. Dosage of the drug Binexcadil Treatment of benign tumors in prostate enlargement: Use 1 mg/day, severe cases can be increased to 2 mg, 4 mg and up to 8 mg; Monitor and consider dose adjustment from 1 to 2 weeks. Treatment of hypertension in primary hypertension: The recommended dose is 1 mg and maintenance use for 1 to 2 weeks. The dose can be increased gradually, to 2 mg, 4 mg, 8 mg & up to a dose of 16 mg; Monitor and adjust dose from 1 to 2 weeks. The usual dose for adults with high blood pressure is between 2 and 4 mg, taken once daily. Please apply and strictly adhere to the exact dose of Binexcadil as directed by your doctor or pharmacist. 3.3. In case of missed dose, overdosage Missed dose:
In case of missed dose, take Binexcadil when you remember. If it is almost time for your next dose, skip the missed dose and take your next dose as prescribed. Never take a double dose of Binexcadil.
Overdose:
In the case of an overdose of Binexcadil, severe hypotension may occur. In this case, please call 911 or take the patient to the nearest clinic or medical facility for treatment.
3.4. Contraindications
Patients with a history of severe hypersensitivity to doxazosin and quinazolin derivatives, such as prazosin or tetrazosin. The patient has a history of orthostatic hypotension. Patients with benign prostatic hypertrophy and comorbid conditions such as urinary obstruction, urinary tract infection or bladder stones. Bineccadil should not be used in patients with benign prostatic hypertrophy and hypotension. Women with high blood pressure and are breast-feeding
3. Notes when using Binexcadil
Do not use the drug on an empty stomach, because when the stomach is empty, the drug can be digested too quickly without showing its pharmacodynamics.
Side effects of Binexcadil
When using Binexcadil, patients may experience side effects including:
Common: Patients may experience dizziness, dizziness, headache; hypotension, leg edema, chest cold, cough; infection in the upper respiratory tract; digestive disorders such as stomach pain, nausea; urinary tract infections;... Uncommon: Patients may have severe disordered reactions in the digestive organs such as constipation, flatulence, gastroenteritis, ..; Pain and discomfort when urinating, especially blood in the urine; Musculoskeletal and central nervous system problems;...
Binexcadil drug interactions
When using Binexcadil with antihypertensive drugs containing Clonidine, the effect of this drug may be reduced. Concomitant use of Binexcadil with non-steroidal anti-inflammatory drugs reduces the hypotensive effect, due to inhibition of prostaglandin synthesis. Concomitant use of Binexcadil with cimedin causes a slight increase in Doxatosin in the blood. Estogen-enhancing drugs can antagonize doxatosin by estrogen retention, increasing blood pressure. Binexcadil storage
Store Binexcadil in a cool, dry place; The appropriate storage temperature for Binexcadil is at room temperature, below 30 degrees Celsius. Do not use the product after the expiry date printed on the package, color change, or taste change. Binexcadil is a prescription drug, so it should only be used with a prescription from a doctor. Do not arbitrarily buy Binexcadil for treatment without consulting a doctor.
