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Bidizem 60 is manufactured and registered by Binh Dinh Pharmaceutical and Medical Equipment Joint Stock Company (Bidiphar), which is used in the treatment of hypertension and chest pain. What is the effect of Bidizem, how to use it, let's find out the use of Bidizem through the article below.
1. What is Bidizem?
Bidizem 60 contains the main active ingredient is Diltiazem hydrochloride 60mg, Bidizem belongs to the group of cardiovascular drugs, is made in the form of tablets, packaged in a box of 3 blisters (1 blister with 10 tablets), 10 blisters (1 blister with 10 tablets).
2. Uses of Bidizem 60
Effect of Bidizem: is a calcium-current inhibitor of benzothiazepine derivatives, the active ingredient Diltiazem inhibits the influx of calcium through the cell membrane to enter the myocardium and vascular smooth muscle, helping to reduce the concentration of calcium present in cells. cells:
Helps increase coronary flow.
Reduces arterial resistance and slows the heart rate moderately, making the heart work less.
When combined with Beta-blockers, there is no negative inotropic effect.
2.1. Indications Bidizem 60 is indicated for use in patients with essential (mild to moderate) hypertension.
Bidizem helps to prevent angina such as Prinzmetal's angina, natural angina but mainly in exertional angina.
2.2. Contraindications Bidizem 60 is contraindicated in the following subjects:
Patients with a history of hypersensitivity to any component of Bidizem Patients with left heart failure or pulmonary edema, severe congestive heart failure, the use of Bidizem use may worsen the symptoms of the disease. Patients with atrioventricular block - 2nd degree, 3rd degree without pacemaker, or dysfunction of the sinus node. Do not use Bidizem on pregnant and lactating women. Bidizem 60 should not be used in patients receiving an infusion of Dantrolen, or Ivabradin.
3. Dosage – How to take Bidizem 60
Bidizem 60 is taken with water without chewing, it is best to take it before or with a meal.
For adults: take 60mg (equivalent to 1 tablet)/1 time, 3 times a day. In severe cases, the dose can be increased to 240mg (4 tablets) or 360mg (6 tablets) per day, the dose adjustment depends on the age and symptoms of the patient, which can be specific as follows:
Elderly people and patients with renal and hepatic impairment: it is necessary to monitor the heart rate, in case the heart rate drops below 50 beats/min, the dose should not be increased. Children: Bidizem 60 is not recommended for use in children. Treatment of overdose:
When using Bidizem 60 drug overdose can lead to acute poisoning with signs such as: hypotension leading to cardiovascular collapse, sinus bradycardia, atrial-ventricular conduction disorders . The direction of treatment is to bring the patient to the emergency room immediately to wash the stomach, drink activated charcoal to reduce the absorption of active ingredients Diltiazem and osmotic diuresis. Some antidotes are suggested such as: glutagon, atropine, calcium gluconate, adrenaline.
4. Bidizem 60 . drug interactions
Contraindications to the combination of Bidizem 60 with:
Dantrolene injection and infusion: there are studies proving that the combination of a calcium inhibitor and dantrolene can be dangerous.
Should not be combined: The combination of Bidizem 60 with Esmolol causes automatic disturbances such as sinus arrest, excessive bradycardia or heart failure, atrioventricular conduction disturbances due to the synergistic effect of the two drugs. above.
Antiarrhythmic drugs: Bidizem 60 itself is a drug with antiarrhythmic properties and in terms of drug interactions Bidizem 60 is considered a drug of this class. Therefore, the concomitant use of Bidizem 60 with antiarrhythmic drugs may increase the adverse effects.
Caution when combining: all drugs after combining with Bidizem 60 need to strengthen close clinical monitoring, and check the electrocardiogram, especially on elderly subjects and new patients. treat.
Alpha blockers: when Bidizem 60 is combined with this drug, it will increase the antihypertensive effect and can especially cause severe orthostatic hypotension.
When Bidizem 60 is combined with Amiodarone, there is an increased risk of atrioventricular block or bradycardia, especially in the elderly.
Beta-blockers: impaired automaticity, heart failure, sinus-atrial and atrioventricular conduction disturbances.
Ciclosporine: the active ingredient Diltiazem inhibits the metabolism of ciclosporine, increasing the concentration of ciclosporine in the blood, similar to Carbamazepine because of the inhibition of metabolism in the liver.
Midazolam (intravenous route): increased signs of sedation, increased plasma concentrations of midazolam due to decreased metabolism in the liver.
Rifampicin: due to increased metabolism in the liver, it reduces the concentration of calcium antagonists in the blood.
Baclofene: when used with Bidizem 60 increases the antihypertensive effect.
Should be noted when combining with Bidizem 60: Antidepressants of the imipramine group and neuroleptics: due to the synergistic effect, it increases the antihypertensive effect, especially the risk of orthostatic hypotension.
5. Adverse effects of Bidizem 60
Common side effects when using Bidizem 60 such as: skin rash, headache, dizziness, lower extremity edema, drowsiness, insomnia, digestive disorders, nausea, constipation, atrioventricular block.
Less common side effects such as urticaria, bradycardia. Rarely when using Bidizem 60 such as: Quincke edema, erythema multiforme, facial rash, hypotension, tachycardia, palpitations, hepatitis, confusion, arthralgia, myalgia.
When experiencing any unwanted effects, it is recommended that the patient immediately notify the doctor for timely treatment.
Hopefully, the above sharing will give you useful information about Bidizem 60 as well as know how to use the drug effectively and safely during the treatment process.
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