Uses of Bicebid 200

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1. What are the effects of Bicebid 200?

The main active ingredient that makes up the drug Bicebid 200 is Cefixim with a content of 200mg. With this active ingredient, Bicebid 200 is classified in the group of antibiotics. They are produced in the form of capsules.
1.1 Bicebid 200 will be indicated in the following cases: Uncomplicated urinary tract infections caused by Escherichia Coli, Proteus mirabilis; or caused by Gram-negative bacilli such as: Citrobacter spp, Enterobacter spp, Klebsiella spp, Proteus spp; People with otitis media caused by Haemophilus influenzae (including beta-lactamase-producing strains), Moraxella catarrhalis (including beta-lactamase-producing strains), Streptococcus pyogenes; People with pharyngitis and tonsillitis caused by Streptococcus pyogenes; Acute and chronic bronchitis caused by Streptococcus pneumonia, Haemophilus influenzae or Moraxella catarrhalis; Community-acquired pneumonia in mild and moderate form; Some cases of pyelonephritis and complicated urinary tract infections caused by susceptible Enterobacteriaceae; Uncomplicated gonorrhea caused by Neisseria gonorrhoeae (including beta-lactamase-producing strains), Salmonella typhi (including multidrug-resistant strains), Shigella-susceptible dysentery (including strains resistant to ampicillin). 1.2 The effect of the drug Bicebid 200 The Cefixim component contained in Bicebid 200 is a semi-synthetic broad-spectrum antibiotic, belonging to the 3rd generation Cephalosporin group. It has antibacterial activity due to its ability to inhibit bacterial cell wall synthesis by binding to essential target proteins (penicillin-binding proteins);
This bactericidal action is achieved by inhibiting the synthesis to form the bacterial cell wall through the acylation of transpeptidase enzymes (which act on membrane binding). As a result, the bacterial cell wall will lack the cross-linking of polytidoglycan chains, so the strength and durability of the wall will be reduced.

2. Dosage and how to use Bicebid 200

For adults will take 2 tablets / day, can be used 1 time or divided into 2 times a day. Each time will be 12 hours apart.
Children:
Children weighing more than 50kg or more than 12 years old will apply the same dosage as adults; Children over 6 months to 12 years old will take 8 mg/kg daily, can be used once or divided into 2 times a day. Each time will be 12 hours apart. The duration of treatment will depend on the type of infection:
For uncomplicated urinary tract infections or upper respiratory tract infections, the treatment time will be from 5 to 10 days; For lower respiratory tract infections or otitis media, treatment will take 10-14 days. Adjust dosage for people with renal failure:
Adults with creatinine clearance from 21 to 60 ml/min should use 300mg/day; Adults with creatinine clearance < 20 ml/min should receive a dose of 200 mg/day; People on hemodialysis and peritoneal dialysis do not need additional doses because cefixime is not lost by hemodialysis; For the treatment of uncomplicated gonorrhea caused by Neisseria gonorrhoeae (including beta-lactamase-producing strains) 400 mg once and as a single dose, in addition to an antibiotic effective against Chlamydia capable of infected. Higher doses (800 mg/time) are also used to treat gonorrhea. In the presence of renal failure, the dose should be adjusted accordingly.

3. Contraindications and some side effects of Bicebid 200

3.1 Contraindications People with a history of hypersensitivity to any of the components of the drug; People with a history of allergy to Penicillin, Cephalosporin, Cephamycin; People with a history of gastrointestinal disease and colitis, especially with prolonged use because of the risk of overgrowth of resistant bacteria such as Clostridium difficile, which can cause severe diarrhea. In this case, it is necessary to stop the drug and treat with other antibiotics (metronidazole, vancomycin,...). However, if mild diarrhea occurs during the first 1-2 days of taking the drug, there is no need to stop the drug; For people with renal failure, hemodialysis must reduce the dose and monitor renal function and blood during drug use, especially when used for a long time, with high doses. Do not use the drug for the elderly with liver failure, renal failure with creatinine clearance < 60 ml/min; Not for use by pregnant or lactating women and children under 6 months of age. 3.2 Some possible side effects Drug users will often experience symptoms such as digestive disorders occurring within 1-2 days of taking the drug; Some people may also experience symptoms of neurological disorders such as: headache, dizziness, insomnia, fatigue and skin problems such as hives; A few will experience symptoms such as severe diarrhea, pseudomembranous colitis, anaphylaxis, angioedema; In a few other cases, there will be thrombocytopenia, white blood cell count, decreased HGB blood level, hepatitis and liver dysfunction; acute renal failure and possible vaginal candidiasis.

4. Instructions for storage and shelf life of Bicebid 200

Bicebid 200 should be stored in a cool, dry place, away from direct light. The effective storage temperature of the drug is not more than 30 ̊C.
The drug will have a shelf life of 36 months from the date of manufacture, do not use the drug when it has expired. Special care should be taken to keep the medicine out of the reach of children.
Drug Bicebid 200 is used in the treatment of bacterial infections such as: urinary tract infections and upper - lower respiratory tract infections,.... To ensure effective treatment and avoid side effects The patient should take the medicine exactly as directed by the doctor or pharmacist.
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