This is an automatically translated article.
Barcavir drug is a drug that is prepared in tablet form, the drug is taken orally with water on an empty stomach. So what is the use of Barcavir?
1. What is Barcavir drug?
Barcavir is manufactured by Incepta Pharmaceuticals Limited - Savar Bangladesh in the form of film-coated tablets. Each Barcavir tablet contains Entecavir 0.5mg and the system of excipients is just enough for 1 tablet.
2. Effects of the drug Barcavir
Entecavir is an active substance similar to purine Nucleoside, this is a guanine derivative with anti-hepatitis B virus (HBV) activity. When entering the body, the active ingredient Entecavir will be converted into the active substance, Entecavir triphosphate. This metabolite will compete with the substrate Deoxyguanosin triphosphate thereby inhibiting the reverse transcriptase enzyme DNA polymerase of the human hepatitis B virus, providing the effect of blocking the stages of virus development. Active ingredient Entecavir is effective against even strains of hepatitis B virus that are resistant to Lamivudin.
Barcavir drug should not be used in the following cases:
Patients with a history of hypersensitivity to any component of Barcavir drug. Children under 16 years old. Pregnant women; Women are breastfeeding.
3. Barcavir is indicated in which disease?
Barcavir is used to treat chronic hepatitis B virus (HBV) infection in adults and children 16 years of age and older when:
The patient has evidence that the hepatitis B virus is active replication, elevated blood DNA-HBV and persistent elevation of liver enzyme levels ALT or AST. The patient has histological evidence of active liver disease.
4. Usage and dosage of Barcavir
Barcavir is used orally at a frequency of 1 time / day. Barcavir should be taken on an empty stomach, at least 2 hours before or 2 hours after a meal.
Barcavir drug dosage depends on each case, specifically as follows:
Chronic HBV has never been treated with nucleoside analogues, it is recommended to use Barcavir drug with a dose of: 0.5 mg / time, 1 time / day ; Patients with a history of HBV infection during treatment with Lamivudine or whose HBV is known to be resistant to lamivudine or telbivudine: use Barcavir at a dose of 1 mg once a day. The optimal duration of Barcavir is unknown, but Barcavir should be used for at least 1 year. Barcavir therapy may be discontinued when:
Patients are HBeAg positive, must be treated with Barcavir at least until HBe seroconversion: loss of HBeAg (HBeAg negative) and HBV DNA becomes negative. below the detection threshold), accompanied by detection of anti-HBe antibodies at 2 consecutive blood draws at least 3-6 months apart, or until HBs seroconversion or in cases where Barcavir does not work after 1 five. HBeAg-negative patients should be treated with Barcavir at least until their DNA-HBV levels are negative (below the detection threshold) and HBs seroconversion occurs, or until Barcavir is no longer effective. In the case of Barcavir treatment lasting more than 2 years, the doctor should regularly reevaluate to determine whether this drug should be continued for the patient or not.
Patients with liver failure do not need to adjust the dose of Barcavir drug while patients with renal failure must adjust the dose of Barcavir according to Clcr, if Barcavir dose < 0.5mg should be switched to a specific oral solution:
Clcr ≥ 50 ml/min: The recommended dose of Barcavir for those who have not used Nucleoside: 0.5 mg/time, once a day; The recommended dose of Barcavir for Lamivudine-resistant people: 1 mg/time, once a day. Clcr 30 - 49 ml/min: The recommended dose of Barcavir for people who have not used Nucleoside: 0.25 mg/time, once a day or 0.5 mg every 48 hours; The recommended dose of Barcavir for Lamivudine-resistant people: 0.5 mg/time, once a day. Clcr 10 - 29 ml/min: The recommended dose of Barcavir for those who have not used Nucleoside: 0.15 mg/time once a day or 0.5 mg/time every 72 hours; The recommended dose of Barcavir for Lamivudine-resistant people: 0.3 mg once a day or 0.5 mg once every 48 hours. Clcr < 10 ml/min Recommended dose of Barcavir for people who have not used Nucleoside: 0.05 mg/time, once a day or 0.5 mg/time, once every 5-7 days; The recommended dose of Barcavir for Lamivudine-resistant people: 0.1 mg/time, once a day or 0.5mg/time, every 72 hours There are currently no data on Barcavir overdose, if used exceed the recommended dose of Barcavir, it is necessary to monitor for abnormal symptoms and immediately notify medical staff for advice and timely treatment.
5. Undesirable effects of the drug Barcavir
Some of Barcavir's side effects are reported according to the specific frequency below:
Common side effects of Barcavir: Blood in urine (9%), increase in creatinine (1-2%), urine glucose (4%), insomnia, headache, dizziness, vomiting, diarrhea, nausea, dyspepsia, increased transaminases (> 10%), increased lipase (7%), increased amylase (2-3%), increased hyperbilirubinemia (2-3%), fatigue. Rare side effects of Barcavir: Rash, hair loss, bloating, indigestion. Rare side effects of Barcavir: Anaphylactic reactions. Some cases of lactic acidosis have been reported when the liver is decompensated or the patient has another serious medical condition or the patient is taking certain other medications.
Common laboratory abnormalities with Barcavir are:
ALT elevation (greater than 5 times the upper limit of normal - 5ULN); Hematuria ; Increased lipase (greater than 2 times the high level of normal - 2ULN); Hyperbilirubinemia (greater than 2 times ULN); Increased ALT (greater than 10 times the ULN and 2 times the concentration at the beginning of treatment); Fasting hyperglycemia (over 250 mg/dl); Increased creatinine (increased by at least 0.5 mg/dl). Immediately notify the doctor of the side effects encountered when taking Barcavir for timely treatment.
6. Drug interactions of the drug Barcavir
There have been no reports of Barcavir drug interactions with other drugs used together, but some notes need to be considered when combining Barcavir:
Ganciclovir, valganciclovir, ribavirin: Increases the effect of Barcavir. Drugs affecting renal function or renal elimination ability compete with Entecavir, which may increase serum Barcavir drug concentration, doctors need to monitor to prevent side effects; Immunosuppressants (cyclosporin, tacrolimus) may alter kidney function, increasing blood levels of Barcavir; Inform your doctor about the drugs you are using for guidance on safe and effective use of drugs. Barcavir can be used to drive or operate machinery because the drug does not affect these subjects.
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