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Afovix is indicated in the treatment of chronic hepatitis B in patients with evidence of active viral replication, long-term elevations in serum aminotransferases or in patients with advanced tissue... , the notes when using the drug Afovix through the article below.
1. Uses of the drug Afovix
What is Afovix? Adefovir Dipivoxil 10mg tablet contains the active ingredient Adefovir Dipivoxil.
Active ingredient Adefovil belongs to the group of antiviral drugs that inhibit the enzyme necessary for the reproduction of hepatitis B virus. Adefovil interferes with the development cycle of HBV to prevent further viral replication, binding specifically to hepatitis B virus. The enzyme DNA polymerase thereby prevents HBV from building the genetic material needed to make more viruses and infect other cells.
Afovix is indicated for the treatment of chronic hepatitis B in adults with evidence of viral activity and long-term elevation of serum aminotransferases, in patients with advanced tissue disease.
2. Dosage of the drug Afovix
Afovix belongs to the group of prescription drugs, so the dose of the drug is prescribed by the doctor based on the patient's condition.
The recommended dose of Afovix in adults with chronic hepatitis B is 1 tablet once daily.
For patients with hepatic impairment: Clinical studies have demonstrated that the pharmacokinetics of Adefovil when administered as a single dose of 10 mg in non-chronic hepatitis B patients with hepatic impairment did not change significantly compared to patients with hepatic impairment. no liver failure. Therefore, it is not necessary to change the dose of Afovix in patients with impaired liver function.
For patients with renal failure: The dose should be changed as follows:
Patients with creatinine clearance from 20 to 49ml/min: Take 10mg every 48 hours; Patients with creatinine clearance from 10-19ml/min: 10mg every 72 hours; Patients on hemodialysis: 10mg every 7 days after hemodialysis for a total of 10 hours. Note that the dose of the drug listed above is for reference only, patients need to use the drug in accordance with the dosage and instructions of the doctor.
3. Side effects of the drug Afovix
Afovix can cause some side effects as follows:
On the digestive system: Diarrhea, dyspepsia, nausea, abdominal pain, flatulence, pancreatitis, increased blood creatinine, decreased blood phosphate, pancreatitis; On the musculoskeletal system: Osteoporosis, myopathy; On the urinary system: Renal failure, proximal tubule disease, Fanconi syndrome; Hepatic: Elevated liver enzymes and acute exacerbations of hepatitis after discontinuation of Adefovir treatment have been reported; Lactic acidosis. Patients should inform their doctor if they experience any unwanted effects during treatment with Afovix.
4. Notes when using the drug Afovix
4.1. Contraindications Contraindicated to use Afovix drug in the following cases:
Patients with hypersensitivity to Adefovir or any component of the drug; Patients with enlarged liver, fatty stools; Patients with acidemia due to metabolism. 4.2. Adefovir is excreted by the kidneys with caution, so co-administration with medicinal products that decrease renal function or compete with renal tubular secretion may increase serum concentrations of Adefovir and/or other drugs. drugs used concurrently. In case of mandatory use, the patient should be monitored for possible side effects.
Elevated liver enzymes during treatment with Adefovir have been reported, so caution should be exercised when treating patients with other liver diseases. Monitor liver and kidney function every 3 months if long-term drug therapy is required. An increased risk of acute hepatitis flare has been reported in patients discontinuing hepatitis B therapy. Therefore, patients should be monitored for liver function during and for at least 2 months after stopping treatment with Adefovir.
Renal toxicity of adefovir is characterized by a slow increase in creatinine concentration, a decrease in serum phosphorus, especially in chronic hepatitis B patients taking a dose of 30 mg/day or HIV-infected patients receiving a dose of 60-120 mg/day. . Long-term use of low-dose adefovir (10 mg/day) may lead to later nephrotoxicity, especially in patients receiving concomitant nephrotoxic drugs such as aminoglycoside antibiotics, cyclosporin, tacrolimus, etc. Vancomycin, a non-steroidal anti-inflammatory drug. Therefore, renal function should be monitored in all patients being treated with Adefovir.
Before treatment with Afovix, the patient should be tested for antibodies to HIV. Adefovir therapy is potent against HIV, and thus may lead to HIV resistance in patients with co-infected hepatitis B and HIV.
There have been reports of the risk of lactic acidosis, fatty liver when treated with Adefovir in particular and nucleoside analogues in general. The majority of cases occurred in female patients, high risk factors were obesity and long-term nucleoside therapy.
For pregnant women, lactating women: The use of Afovix in these subjects should be prescribed by a doctor based on the benefits and risks.
For drivers, operating machines: Afovix can cause some side effects such as drowsiness, headache, dizziness... affecting the patient's ability to concentrate. Therefore, caution should be exercised when using the drug in patients who drive or operate machinery.
Store Afovix at room temperature, away from sunlight and high humidity.
5. Drug interactions
Afovix may cause the following interactions:
Caution should be taken when administering Adefovir with drugs that are actively excreted by the renal tubules, because of the risk of competing for the elimination pathway that may increase serum concentrations. of either drug; Do not use the combination of Adefovir and Tenofovir Disoproxil Fumarate. The occurrence of drug interactions increases the risk of having effects and reducing the treatment effect of Afovix, so to ensure safety and effectiveness in treating patients, it is necessary to inform the doctor about the drugs and foods that are being used. used before taking Afovix.
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