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B-neurine drug is one of the drugs used to treat and prevent vitamin B group deficiency due to nutrition or medication by combining with other vitamins. To better understand what is the drug B-neurine? What are the uses of B-neurine? What are the harmful interactions of B-neurine drugs? What is the correct way to drink? What points to pay attention to or note when using? The following article will help you better understand the drug B-neurine.
1. What is B-neurine drug?
B-neurine is a synthetic drug whose main ingredient is Thiamine mononitrate - Pyridoxine hydrochloride - Cyanocobalamin. The drug is prepared in the form of film-coated tablets, manufactured by Vacopharm pharmaceutical joint stock company.
Ingredients in 1 B-neurine tablet include:
Thiamine mononitrate with 125mg Pyridoxine hydrochloride content with 125mg Cyanocobalamin content with 125mcg content Excipients: Tapioca starch, Magnesium stearate, Lactose, Talc powder, Titanium dioksid, Polyvinyl pyrrolidone K30, Sodium starch glycolate, Hydroxypropyl methylcellulose 615, Erythrosine lake, PEG 6000.
B-neurine is prescribed by doctors for use in the following cases:
Treatment and prevention of vitamin B deficiency caused by poor nutrition or other causes. Detoxification treatment of patients with alcoholism. In some pain syndromes due to rheumatism or neuritis drugs are used in high doses.
2. What is the use of B-neurine?
2.1 Pharmacodynamics Vitamin B1 has practically no pharmacological effects, even when taken in high doses. Thiamine pyrophosphate - a physiologically active form of Thiamine, is a carbohydrate-metabolizing coenzyme responsible for decarboxylation of alpha-cetoacids such as pyruvate and alpha-cetoglutarate and in the use of pentose in the hexose monophosphate cycle. Thiamine deficiency will cause edema, peripheral neuritis along with cardiovascular symptoms such as dyspnea on exertion, tachycardia, palpitations and other cardiac disorders. Vitamin B6 exists in 3 forms: pyridoxal, pyridoxine and pyridoxamine, when entering the body, it is converted into pyridoxal phosphate and partly into pyridoxamine phosphate. These two substances act as coenzymes in protein, glucose and lipid metabolism. Pyridoxine participates in the synthesis of gamma-aminobutyric acid (GABA) in the central nervous system and participates in the synthesis of hemoglobin. Vitamin B12 is the common name for a group of cobalt-containing compounds (cobalamins), of which cyanocobalamin and hydroxocobalamin are the two main drugs used in clinical practice. In the human body, these cobalamins form the active coenzymes methylcobalamin and 5-deoxyadenosylcobalamin which are essential for cell replication, growth, hematopoiesis, nucleoprotein and myelin synthesis.
2.2 Pharmacokinetics Vitamin B1: The absorption of thiamin from the daily diet through the gastrointestinal tract is due to active Na+ dependent transport. In adults, the minimum daily requirement is 1mg. When absorbed at this level, little or no thiamine is excreted in the urine. When the minimum requirement is exceeded, the thiamine stores in the tissues are first saturated. The excess is then excreted in the urine as an intact thiamine molecule. Vitamin B6: is rapidly absorbed from the gastrointestinal tract, the drug is stored mostly in the liver and partly in the muscles and brain. Excreted by the kidneys as metabolites. If the amount of drug taken into the body exceeds the daily requirement, most of the drug will be eliminated unchanged.
Vitamin B12 : After oral administration, vitamin B12 is immediately absorbed in the gastrointestinal tract, in the second half of the ileum. When reaching the stomach, under the action of gastric juice, vitamin B12 is released from food protein, then it is attached to intrinsic factor to form vitamin B12-intrinsic factor complex. As this complex descends to the terminal ileum, it binds to receptors on the ileal mucosa and is then actively absorbed into the circulation. In the bloodstream, vitamin B12 binds to transcobalamin II, a plasma globulin, for transport into tissues. The liver is where up to 90% of vitamin B12 stores are stored, with some stored in the kidneys. Peak plasma concentrations are reached 8 to 12 hours after oral administration. Vitamin B12 is metabolised in the liver, the elimination half-life is about 6 days. Vitamin B12 is eliminated via the bile and has a hepato-enteric cycle. Vitamin B12 in excess of the daily requirement is excreted in the urine largely as unchanged drug. Vitamin B12 crosses the placenta and breast milk.
2.3 Contraindication of B-neurine Drugs Patients who are allergic to any ingredient or excipients of B-neurine drugs People with malignant tumors Patients with Leber's disease or vision loss caused by smoking 2.4 Effects Side effects when using B-neurine Nausea, cramps, urticaria, hypotension, peripheral nerve syndrome. In relation to Pyridoxine (Vitamin B6): Doses of 200 mg/day and long-term (over 2 months) can cause severe peripheral neuropathy, progressing from unsteady gait and frostbite to frostbite and clumsiness. hand. This condition can be reversed when the drug is stopped, although there are still some sequelae. 2.5 Drug Interactions Related to Vitamin B1 Ingredients People who are allergic to penicillin are more likely to be allergic to vitamin B1 and vice versa.
Related to Vitamin B6 component Pyridoxine reduces the clinical effect of levodopa in the treatment of Parkinson's disease; but this is not the case with a mixture of levodopa–benserazide or levodopa-carbidopa.
Doses of 200 mg/day may cause a 40-50% decrease in phenytoin and phenobarbital blood levels in some patients
Pyridoxine may alleviate depression in women taking oral contraceptives. Oral contraceptives may increase the need for vitamin B6
Related to the composition of Vitamin B12 Absorption of vitamin B12 from the gastrointestinal tract may be reduced when taken with aminosalicylic acid, neomycin, histamine H2 receptor antagonists. and colchicine.
Serum concentrations may be reduced when used concomitantly with oral contraceptives.
Chloramphenicol given parenterally may reduce the effect of vitamin B12 in anemia.
The therapeutic effect of Vitamin B12 may be reduced when used concurrently with Omeprazole. Omeprazole reduces gastric acid, thus reducing vitamin B12 absorption. If it is necessary to use in combination, it should be used parenterally with vitamin B12.
2.6 Precautions when using B-neurine Vitamin B6 activates the peripheral enzyme dopadecarboxylase. Therefore, vitamin B6 should not be used with levodopa if this substance does not have a dopadecarboxylase enzyme inhibitor combination.
After a period of using Pyridoxine at a dose of 200mg/day, neurotoxicity may have been observed (such as severe peripheral neuropathy and severe sensory neuropathy). Doses of 200mg per day for more than 30 days can cause pyridoxine dependence syndrome.
Vitamin B12: regularly monitor the patient's blood. Most megaloblastic anemia is caused by vitamin B12 deficiency; or folic acid. It is imperative to determine the cause before treatment, not to use folic acid to treat megaloblastic anemia of unknown cause, unless it is combined with vitamin B12, otherwise it will promote damage. neuropathy due to vitamin B12 deficiency).
Caution when using for pregnant and lactating women
3. How to use B-neurine effectively
3.1 How to take Take the medicine with cooled boiled water, do not crush the tablet or mix it with other mixtures. Should take the drug during the day to avoid insomnia at night 3.2. Dosage Adults: Take 1-2 tablets each time x 2-3 times/day. Children: Take 1/2 adult dose or as directed by a physician. 3.3. Treatment in case of emergency or overdose In case of emergency or overdose, call 911 or go to the nearest local health facility. Relatives need to provide the doctor with the prescription they are taking, the medicines they are taking, including prescription and non-prescription drugs.
What to do if a dose is missed?
In case you miss a dose while taking the medicine, take it as soon as possible (usually it can be taken 1-2 hours before the time ordered by the doctor). However, if it is almost time for your next dose, skip the missed dose and take your next dose at the prescribed time. Be careful not to double the prescribed dose.
4. Cautions, warnings and cautions
4.1. Note before taking B-Neurine Use the drug strictly according to the doctor's prescription. Do not use this medicine if you are allergic to any of its ingredients or have been warned by your doctor or pharmacist. Use with caution in children, pregnant or lactating women or operating machinery.
4.2. Notes on taking B-Neurine during pregnancy General note during pregnancy: Drugs used during pregnancy can cause adverse effects (miscarriage, teratogenicity, fetal malformations... ) to any stage of pregnancy, especially the first trimester. Therefore, it is best not to use the drug for pregnant women. In the case of mandatory use, it is necessary to consult carefully with your doctor, pharmacist before making a decision.
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