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Aumirid medicine 200mg has the main active ingredient is Amisulprid 200mg and other excipients in sufficient quantity. Aumirid 200mg belongs to the group of psychotropic drugs, prepared in the form of tablets, suitable for direct oral use.
1. What is Aumirid 200mg?
Aumirid medicine 200mg has the main active ingredient is Amisulprid 200mg and other excipients in sufficient quantity. Aumirid 200mg belongs to the group of psychotropic drugs, is made in the form of tablets, suitable for oral use.
1.1. Pharmacodynamic properties Active ingredient Amisulpride has high affinity for dopamine D2/D3 receptors, no affinity for D1, D4 and D5. Amisulpride also has no affinity for serotonin, alpha-adrenergic, histamine H1 and cholinergic receptors. Amisulpride also does not bind to the sigma site.
Active ingredient Amisulprid blocks presynaptic D2/D3 receptors, causing Dopamine release, effective for signs and symptoms of schizophrenia.
1.2. Pharmacokinetic properties After oral administration of a therapeutic dose of 50 mg, the active substance Amisulpride has two peaks of absorption: 1 hour after oral administration and 3 to 4 hours after oral administration. Absolute bioavailability is 48%. Approximately 4% of a therapeutic dose of Aumirid 200mg is metabolized to inactive substances. The mean half-life is about 12 hours. Aumirid 200mg is mainly excreted unchanged in the urine.
2. What disease does Aumirid 200mg treat?
Aumirid 200mg is indicated for the treatment of acute and chronic schizophrenia with signs including positive symptoms such as delusions, hallucinations, thought disturbances or negative symptoms indicating the intention to withdraw from life. social life.
3. Usage and dosage of Aumirid 200mg
Dosage of Aumirid 200mg:
Acute phase: 400 mg - 800mg/day. In some cases, the therapeutic dose can be increased to 1200 mg/day. Adjust dose according to patient response. Use the lowest effective maintenance dose. For those with both negative and positive symptoms, the dose should be adjusted for optimal control of positive symptoms. For patients with predominantly negative symptoms, the dose should be in the range of 50-300 mg/day. Usage: therapeutic dose of 300mg/day or less, taken once/day; Dosage over 300 mg/day divided into 2 times/day. Renal impairment: those with a creatinine clearance of about 30 - 60 ml/min take 1⁄2 of the therapeutic dose; People with creatinine clearance about 10-30 ml/min take 1/3 of the therapeutic dose. In case of overdose/forgotten dose:
In case of overdose: Prescription drugs require a prescription from a treating doctor. Over-the-counter medicines require an instruction sheet provided by the manufacturer. You need to pay attention to carefully read and follow the exact treatment dose indicated on the prescription or instruction sheet for Aumirid 200mg. When using Aumirid 200mg drug overdose may appear signs and symptoms including feeling of drowsiness, coma, hypotension and extrapyramidal symptoms. There is currently no specific antidote for an overdose of this drug. When you discover someone has overdosed, you need to take them to a medical facility immediately for proper treatment. The doctor will prescribe appropriate measures to support the body. If severe extrapyramidal symptoms are present, anticholinergic agents should be used. In case of missed dose: Usually drugs including Aumirid 200mg can be taken within 1-2 hours compared to prescribed in the prescription. However, if the time to forget to take the medicine is too far away from the time it should be taken, it is not advisable to take a make-up dose, which can be dangerous for the body. You need to note that you should follow it properly or consult your treating doctor before making a decision.
4. Undesirable effects of the drug Aumirid 200mg
Common undesirable effects such as insomnia, anxiety, agitation. Uncommon side effects include somnolence, constipation, diarrhea, nausea, vomiting or a feeling of dry mouth. Undesirable effects similar to other neuroleptics: Increase in plasma prolactin index, which returns to normal when the drug is discontinued. Increase body weight. Acute dystonia includes torticollis, eye rotation, and jaw tightness. Extrapyramidal symptoms include tremor, decreased movement, increased salivation, and restlessness. It will return to normal when the drug containing the active ingredient Amisulpride is discontinued and treatment with anti-Parkinson drugs. Tardive dyskinesia. Decreased blood pressure, bradycardia, prolongation of the QT interval. Allergic reactions, increased liver enzymes, neuroleptic malignant syndrome: very rare. Usually these side effects go away when you stop using Aumirid 200mg. If you experience any other rare side effects that are not listed in the leaflet, please inform your doctor immediately.
5. Drug interactions of Aumirid 200mg
Aumirid 200mg may cause interactions with the following drug groups:
Class Ia antiarrhythmic drugs such as Quinidine, Disopyramid, Procainamide. Class III antiarrhythmic drugs such as Amiodarone, Sotalol. Levodopa . Aumirid 200mg should not be combined with:
Amisulprid increases the effect of alcohol on the central nervous system. Drugs that slow the heart rate such as beta-blockers, calcium channel blockers. Drugs that cause hypokalemia such as diuretics, laxative stimulants, Amphotericin B used intravenously, Glucocorticoids, Tetracosactide. Specific neuroleptics such as Pimozide, Haloperidol, Imipramine, lithium. Aumirid 200mg should be considered in combination with:
Central nervous system depressants such as tranquilizers, anesthetics, analgesics, H1-antihistamines causing drowsiness, Barbiturates, Benzodiazepines and anti-anxiety drugs. other Europe. Drugs that lower blood pressure. Specific Dopamine agonists such as Levodopa, because they reduce the effect of the active substance Amisulpride.
6. Some notes when using Aumirid 200mg
Aumirid 200mg is contraindicated in the following cases:
People who are sensitive or sensitive to any of the ingredients of the drug. People with prolactin-dependent tumors such as breast cancer, pituitary prolactin tumors. People with pheochromocytoma. Children under 15 years old. Pregnant women and those who are breastfeeding. Normally, people who are allergic to any substance in the composition of the drug should not use Aumirid 200mg. Other cases are specified in the drug leaflet or prescription of the treating doctor. Contraindications to Aumirid 200mg must be understood as absolute contraindications, ie not for any reason that contraindications are flexible to use this drug.
Note to the following special group of people:
People who often drive or operate machinery: Aumirid 200mg affects reflexes, so it affects the ability to drive and operate machines. The subjects to note before using Aumirid 200mg are the elderly, pregnant women, lactating women, children under 15 years old, people with liver failure, kidney failure, hypersensitivity to any substance in the composition of the drug... Or those who are suffering from myasthenia gravis, hepatic coma or stomach ulcers. Pregnant women: You need to carefully consider and consult your treating doctor before using Aumirid 200mg. Even though drugs have been tested, there are still risks when using them. Breast-feeding: Consult a treating physician after weighing the potential benefits and risks for mother and baby. You should not arbitrarily use Aumirid 200mg without carefully reading the instructions for use and instructions of your doctor. Some other cautions when using the drug:
Similar to other neuroleptic drugs, neuroleptic malignant syndrome includes symptoms of high fever, muscle stiffness, instability, increased CPK,... may happen. When you have a high fever, especially when using drugs in high doses, you must stop taking all antipsychotic drugs. The drug Aumirid 200mg lowers the seizure threshold, it should be used with caution in people with a history of epilepsy. Only use the drug Aumirid 200mg for people with Parkinson's disease when absolutely necessary, because it will make the condition worse. When wanting to stop using Aumirid 200mg, the dose should be reduced gradually, avoiding abrupt discontinuation. Aumirid 200mg drug prolongs the QT interval, there is a risk of severe ventricular arrhythmias such as torsades de pointes if you have had bradycardia or less than 55 beats / min, decreased blood potassium, congenital prolongation of the QT interval. Above is information about uses, dosage and notes when using Aumirid 200mg, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using.
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