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Soladeno drug containing the active ingredient Amisulpirid is indicated in the treatment of acute and chronic mental disorders... Let's learn about the uses, the notes when using Soladeno through the article below.
1. Uses of the drug Soladeno
Active ingredient Amisulpiride acts selectively and predominates on Dopaminergic receptors D2, D3 in humans, the blocking effect of Dopaminergic receptors in the black sickle system of Amisulpiride is more dominant than the blocking effect on Dopaminergic in the human body. cloud.
Soladeno is indicated in the treatment of acute and chronic schizophrenia with symptoms such as hallucinations, paranoia, thought disturbances or no symptoms (not expressing emotions, preferring to live alone). established) including cases where no symptoms predominate.
2. Dosage of the drug Soladeno
Dosage of Soladeno 100mg, 200mg depends on the age and condition of the patient as follows:
Stage of acute psychosis: Dosage is from 400 to 800mg/day. In some cases the dose can be increased to 1200mg/day. The dose is adjusted based on the clinical response of each patient; Mixed phase between symptomatic and asymptomatic: The dose should be adjusted for optimal control of disease symptoms, the dose usually ranges from 400-800mg/day; Predominant asymptomatic phase: The recommended dose is 50-300mg/day, adjusted according to the individual patient. In some cases the dose can be up to 300mg / time / day. Should take the drug in the evening for better effect; Elderly: Soladeno should be used with caution in the elderly, because the risk of side effects such as hypotension and sedation is increased; Children: The efficacy and safety of Soladeno have not been established in patients under 18 years of age; Patients with renal impairment: Amisulpiride is eliminated mainly by the kidneys. Therefore, in patients with renal failure with a creatinine clearance of 30-60ml/min, the dose should be reduced by 2 and reduced to 1/3 of the dose in patients with a creatinine clearance of 10-30ml/min. For patients with renal failure with creatinine clearance less than 10ml/min, special caution should be exercised when treated with Soladeno; Patients with hepatic impairment: There is no need to reduce the dose of Soladeno in patients with hepatic impairment.
3. Side effects of the drug Soladeno
Soladeno 200 and Soladeno 100 drugs can cause some unwanted effects as follows:
Common: Insomnia, anxiety, agitation, constipation, drowsiness, vomiting, nausea, dry mouth, syndrome extrapyramidal (hypertonicity, tremor, increased salivation, restlessness, dyskinesia), increased blood prolactin levels, increased lactation, breast enlargement, breast tenderness, dyskinesia, weight gain, lower blood pressure; Rare: Tardive dyskinesia characterized by involuntary movements of the face and tongue has been reported, convulsions, elevated liver enzymes, hyperglycemia, allergic reactions. Patients need to notify their doctor in case they experience unwanted effects while being treated with Soladeno.
4. Notes when using Soladeno
4.1. Contraindications The use of Soladeno is contraindicated in the following cases:
Patients with hypersensitivity to Amisulpiride or any of its ingredients; Patients with prolactin-dependent tumors such as breast cancer, prolactin-secreting tumors; Patients with pheochromocytoma; Children under puberty; Pregnant women; Concomitant use of Soladeno with Levodopa is contraindicated. 4.2. Caution when using Soladeno, like other sedatives, can cause neuroleptic syndrome with symptoms such as muscle spasticity, hyperthermia, autonomic disturbances, cognitive changes... In case the patient notices signs of hyperthermia when taking high daily doses, Soladeno should be discontinued immediately. An increased risk of hyperglycaemia has been reported in patients treated with amisulpiride, so patients with diabetes mellitus or with risk factors for diabetes on amisulpiride therapy should have their blood glucose monitored appropriately. Amisulpiride is excreted by the kidneys, so the dose should be reduced in patients with renal impairment. Soladeno can lower the seizure threshold, so patients with a history of seizures should be carefully monitored while taking the drug. Soladeno may increase the risk of hypotension and sedation in elderly patients. Soladeno should be used with caution in patients with Parkinson's disease because it may aggravate the condition. Soladeno should be used with caution in patients with cardiovascular disease or in patients with a family history of prolongation of the QT interval on the electrocardiogram. Therefore, avoid taking Soladeno with antipsychotics. Soladeno should be used with caution in patients at risk of stroke. Soladeno can cause drowsiness, so patients should be careful not to drive or operate machinery while taking the drug.
5. Drug interactions
Alcohol enhances the sedative effect of Amisulpiride. Caution should be exercised when combining Soladeno with CNS depressants such as anesthetics, narcotic analgesics, H1 antihistamines, benzodiazepines, barbiturates, anxiolytics, clonidine, antihypertensive drugs. Use caution when using Amisulpride with drugs that prolong the QT interval on the electrocardiogram such as antihistamines, class IA, class III antiarrhythmics, antipsychotics, antimalarials, drugs that cause electrolyte imbalance . Drug interactions occur that increase the risk of having an effect and reduce the therapeutic effect of Soladeno, so to ensure safety and effectiveness in treating patients, it is necessary to inform the doctor about the drugs and foods that are being treated. used before taking the drug.
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