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Atocib 60 tablets of Hau Giang Pharmaceutical company are prescribed by doctors to be used in cases of leprosy, ankylosing spondylitis, menstrual pain,... So what is Atocib 60? ? What is Atocib 60 used for? What is the correct way to drink? What points to pay attention to and pay attention to when taking this drug? The following article will help you better understand the use of Atocib 60.
1. What are the uses of Atocib 60?
1.1. What is Atocib 60? Atocib 60 has the main ingredient etoricoxib 60 mg and excipients just enough for 1 tablet. Atocib 60 is a product of DHG Pharmaceutical Company Limited. Packed in a box of 3 blisters, each blister contains 10 pills and is in the form of film-coated tablets.
Atocib 60 belongs to the group of non-steroidal anti-inflammatory drugs, with anti-inflammatory, antipyretic and analgesic activities.
Mechanism of pharmacological action is selective inhibition of COX-2, it does not inhibit prostaglandin synthesis in the stomach, does not affect platelet function.
1.2. What is Atocib 60 used for? Atocib 60 is well absorbed from the oral route. Absolute bioavailability is about 100%. Food does not affect the absorption of the drug. Atocib 60 is about 92% protein bound in plasma.
Atocib 60 is extensively metabolised with less than 1% of the dose recovered in the urine in the parent form. The main pathway by which it is metabolized to form 6-hydroxymethyl derivatives is performed with the catalysis of cytochrome P450 (CYP) enzymes. The majority of Atocib 60 is eliminated primarily by metabolism, followed by renal excretion. Steady-state concentrations of Atocib 60 are achieved within 7 days of treatment when patients receive a dose of 120 mg once daily, with a cumulative ratio close to 2, corresponding to a cumulative half-life of about 22 o'clock.
Atocib 60 is indicated for the treatment of the following cases:
Acute and chronic treatment of some signs and symptoms in osteoarthritis (degenerative joint) or rheumatoid arthritis. Treatment in ankylosing spondylitis. Treatment in acute gouty arthritis (acute gout). Relieves acute and chronic pain. Treatment of primary dysmenorrhea.
2. How to use Atocib 60
2.1. How to use Atocib 60 Each drug or a pharmaceutical product is manufactured by the company in a form corresponding to the form of use, the route of administration is different. The usual routes of administration are: oral, injectable, topical, and suppository.
Patients should carefully read the instructions on how to take Atocib 60 as indicated on the instruction sheet of the drug, the patient must not arbitrarily use the drug by other routes not mentioned in the instruction sheet of Atocib medicine. 60
Atocib 60 comes in film-coated tablets that should be taken orally. Can be taken with or without food.
2.2. Dosage of Atocib 60 As prescribed by a specialist, the patient can refer to the dose as follows: The patient should take Atocib 60 in the shortest time and the appropriate dose to be effective.
Osteoarthritis, arthritis: use 30mg to 60mg/time per day. Rheumatoid arthritis, rheumatoid spondylitis: 90mg/time per day. Acute gouty arthritis (acute gout), acute pain or primary dysmenorrhea: 120mg once daily. Maximum treatment is 8 days. Chronic pain: 60mg once a day. Renal impairment: Creatinine clearance more than 30 ml per minute: no dose adjustment is required. Creatinine clearance less than 30 ml per minute: contraindicated. Hepatic impairment: Mild hepatic impairment (Child-Pugh grade 5 to 6): do not exceed 60 mg per day. Moderate hepatic impairment (Child-Pugh 7 to 9): do not exceed 30 mg per day. Severe hepatic impairment (Child-Pugh more than 10): contraindicated. Elderly: No dose adjustment is required. Handling missed dose: If the patient has missed a dose, take it as soon as he remembers. But if it is almost time for your next dose as directed, skip the missed dose and take your next dose as scheduled. Patients should not take more medicine or take a double dose to make up for the missed dose.
Management of Overdose: Acute overdosage has been reported with Atocib 60 although adverse effects were not reported in the majority of cases. The most common adverse events were consistent with the safety profile of Atocib 60 (eg, gastrointestinal effects, cardio-renal effects).
In the event of an overdose of Atocib 60, the usual supportive measures should be used, for example, removal of unabsorbed drug from the gastrointestinal tract, monitoring and symptomatic treatment.
drug Atocib 60 cannot be removed by hemodialysis; Elimination of atocib 60 by peritoneal dialysis has not been established.
3. Contraindications of Atocib 60
Contraindications
Atocib 60 should not be used in the following cases:
History of being allergic to any ingredients or excipients in the formula of the drug. The patient had gastric bleeding, advanced peptic ulcer disease, and inflammatory bowel disease. People with a history of bronchospasm, allergic rhinitis or bronchial asthma, nasal polyps, urticaria and Quincke's edema or allergic reactions after taking Aspirin and other NSAIDs. Severe liver failure with a Child-Pugh score of 10 or higher or serum albumin less than 25g per liter. People with high blood pressure that is not well controlled, or regularly rises to 140 over 90 mmHg. Patients under 16 years of age. People with congestive heart failure, peripheral artery disease or vascular disease and ischemia. Drug Interactions:
Several interactions of Atocib 60 have been reported, including:
Warfarin : Change in Prothrombin time. Rifampicin: Decreased plasma concentrations of Etoricoxib. Methotrexate, oral contraceptives Ethinyl estradiol, Lithium, Conjugated estrogens: Increased blood levels of these substances. Diuretics, Angiotensin-converting enzyme inhibitors, Angiotensin II antagonists: Reduces antihypertensive effect. Aspirin: Increased risk of gastrointestinal ulcers. To ensure safety and effectiveness, tell your doctor about all medications, health foods you are taking, and other illnesses you have.
Use in pregnancy and lactation
Pregnant women: Atocib 60 was not teratogenic in reproductive toxicity studies performed in rats at a dose of 15 mg/kg per day. . However, in rabbits, cardiovascular malformations have been reported. There are no adequate and well-controlled studies in humans. Therefore, Atocib 60 is contraindicated for this subject. Lactation: Studies in rats have shown that Atocib 60 is excreted in human milk. Consider discontinuing use or stopping breast-feeding while taking Atocib 60. People who drive and operate machines
Atocib 60 side effects such as dizziness, drowsiness, dizziness may affect the ability to stay awake to drive and use machines. Patients should be cautious when combining.
4. Notes when using Atocib 60
Caution should be exercised when treating patients at risk of developing gastrointestinal complications with non-steroidal anti-inflammatory drugs (NSAIDs); patients used alone or in combination with any other NSAID or acetylsalicylic acid; Patients with a history of gastrointestinal disease such as ulcerative colitis or gastrointestinal bleeding.
Atocib 60 should be used with caution in patients with myocardial infarction, congestive heart failure, or stroke, hypertension, hyperlipidemia, diabetes mellitus, and smoking.
Renal dysfunction and cirrhosis .
Severe hypersensitivity reactions (such as anaphylaxis and angioedema) have been reported in patients receiving Atocib 60.
Risk of cardiovascular thrombosis:
Non-steroidal anti-inflammatory drugs (NSAIDs), not The use of aspirin, given by the systemic route, may increase the risk of cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may appear as early as the first few weeks of taking the drug and may increase with duration of use. The risk of cardiovascular thrombosis is observed mainly at high doses.
Pregnancy and breast-feeding: Etoricoxib is contraindicated for pregnant women.
Depending on the importance of the drug to the mother, decide to either discontinue breastfeeding or discontinue the drug.
Effects of drugs on work: When taking etoricoxib, there is a possibility of dizziness, lightheadedness or drowsiness, should limit driving, operating machinery, working at height and other cases.
5. Side effects of Atocib 60
Very common: Abdominal pain. Common: Osteoarthritis, edema, fluid retention, headache, or dizziness, tachycardia and arrhythmia, hypertension, possible bronchospasm or gastritis, constipation and flatulence, diarrhea or acid reflux, vomiting or nausea, body discomfort, indigestion or mouth ulcers, esophagitis, increased AST and ALT, bruising, flu-like illness and weakness. Uncommon: Infections of the upper respiratory tract, urinary tract, gastroenteritis, anemia, thrombocytopenia or leukopenia, hypersensitivity and anxiety, depression, hallucinations, decreased sensitivity, proteinuria or changes intestinal motility changes,... Rare: Anaphylaxis, anaphylaxis, vasculitis, restlessness, confusion, liver failure, hepatitis and jaundice, Stevens-Johnson syndrome or chromosomal erythema fixed factor, toxic epidermal necrolysis, hyponatremia. Serious side effects have been reported: Nephrotoxicity including nephrotic syndrome and interstitial nephritis. There is also an increased risk of cardiovascular thrombosis. If the patient finds any side effects, immediately notify a qualified doctor or pharmacist for timely treatment.
6. How to store Atocib 60
Store Atocib 60 in a cool, dry place, the temperature does not exceed 30°C, in the original packaging and avoid direct light. Keep Atocib 60 out of the reach of children. Do not use when Atocib 60 has expired before the expiry date printed on the package. The user should carefully read the instructions on the storage of the drug listed on the package and the instruction sheet of Atocib 60. When the user does not use the drug or the drug Atocib 60 has expired, it must be collected. and dispose of the medication according to the manufacturer's or medical personnel's instructions.
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