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Asperlican is an antifungal medicine. With the main ingredient being Fluconazole, Asperlican drug is often used in the treatment of Candida infections, in addition to some other fungal strains such as Cryptococcus neoformans that cause meningitis. Let's find out more about Asperlican drug use through the article below.1. What are the effects of Asperlican?
Asperlican belongs to the group of drugs that treat parasites, infections, viruses and fungi, with the main ingredient being Fluconazole 150mg. Fluconazole is active against peripheral or systemic fungi, especially Candida.Asperlican drug is made in the form of hard capsules and is indicated in the following cases:
Treatment of Candida infections in the vagina, vulva, urinary tract. Treatment of candida infections in the mouth, pharynx, esophagus, and peritoneum. Treatment of systemic candidiasis in the lungs and blood vessels. Treatment of meningitis caused by the fungus Cryptococcus neoformans. Treatment of diseases associated with Blastomyces, Coccidioides immitis and Histoplasma. In addition, Asperlican is also used in the prophylaxis of Candida infections in bone marrow transplant patients undergoing chemotherapy or radiation therapy, immunocompromised patients, cancer patients, or HIV/AIDS patients. .
2. How to use and dose Asperlican
Asperlican is taken orally, taking the tablet whole with water. Depending on the type of fungus, response ability and kidney function of the patient, the dose will be adjusted accordingly.For fungal diseases in general, patients should note that Asperlican should be used continuously for the recommended time and until laboratory tests and clinical symptoms show that the fungus has been eliminated. In addition, intermittent use of the drug can lead to a relapse of the disease.
The use of Asperlican in the treatment of cryptococcal meningitis and HIV/AIDS patients can be prolonged so that the disease does not recur.
Dosage of Asperlican in infants is as follows:
Newborns under 2 weeks old: 3 - 6mg/kg body weight/time, each time taking 72 hours apart. Children 2 - 4 weeks old: 3 - 6mg/kg body weight/time, each time taking 48 hours apart. The specific dosage of Asperlican in children is as follows:
Prophylactic treatment: 3mg/kg body weight/day for superficial fungal infections, 6-12mg/kg body weight/day for systemic fungal infections. Fungal treatment: 6mg/kg body weight/day or 12mg/kg body weight/day can be used and divided into 2 total doses per day if the fungal infection persists, but should not exceed 600mg/day. Dosage of Asperlican in adults is as follows:
Treatment of Candida infections in the vagina and vulva: 150mg/time/day (equivalent to 1 tablet/time/day), taking a single dose. In the next 4-12 months, a dose of 150mg/month (1 tablet/month) can be used to prevent recurrence. Treatment of candida infections in the mouth and pharynx: 150mg/time/day (equivalent to 1 tablet/time/day, used for about 1-2 weeks) equivalent to 1 tablet of Asperlican / time / day), use continuously for at least 3 weeks and after the symptoms are gone, need to use it for at least 2 more weeks. / time / day) for the first 3 days of the course of treatment, then 150mg / time / day (equivalent to 1 tablet / time / day), used for a minimum of 4 weeks and after the symptoms are gone, need to take more At least 2 more weeks Treatment of cryptococcal meningitis: 450mg/time/day (equivalent to 3 Asperlican tablets/time/day) in the first day of treatment, then 1 - 3 tablets/day. Once a day and for a minimum period of 6 to 8 weeks after the CSF culture is negative.To avoid relapse in HIV patients, it is necessary to use Difuzit at a dose of 1 tablet once a day, administered continuously. continued for a long time . Prophylactic treatment of Candida infections in bone marrow transplant surgery patients: 3 Asperlican tablets/time/day (equivalent to 450mg/time/day). Prophylaxis is given a few days before the neutrophil count drops (predictably) and continues for a further 7 days after the neutrophil count reaches a value above 1,000/mm3. Dosage of Asperlican in patients with renal failure is recommended to be adjusted as follows:
Treatment of Candida infections of the vagina and vulva (monotherapy): No dosage adjustment is required. Multitherapy: Dosage is adjusted based on creatinine clearance (ml/min).
3. Asperlican side effects
Asperlican can cause some unwanted side effects with the frequency of occurrence as follows:Common: Abdominal pain, nausea, diarrhea; dizziness, headache. Uncommon: Pruritus, rash; elevated serum bilirubin and transaminases (mild and temporary). Rare: Asperlican rarely causes side effects such as elevated serum transaminases (patients have to stop taking the drug); anemia, eosinophilia, leukopenia, neutrophils and platelets; Stevens-Johnson syndrome, scaly skin; hypotension, hypokalemia, pleural effusion, edema, urinary frequency, fever, anaphylaxis. If you see any unusual symptoms after taking Asperlican, the patient should immediately report it to a doctor or go to a medical facility soon for a health check.
4. Some notes when using Asperlican drug
Do not use Asperlican in people with hypersensitivity to the drug's components in particular or to azole antifungal drugs in general. People with liver failure, kidney failure, prolonged QT interval, cardiac arrhythmia should be cautious when using Asperlican. Asperlican should be used during pregnancy only when clearly needed and after weighing the potential benefits of treatment to the mother over the potential effects on the fetus. In addition, research information on this group of subjects is also limited. Breastfeeding women should not take Asperlican because the drug can be excreted in breast milk at high concentrations like plasma, affecting the nursing infant. Limit the activities of driving or operating, operating machinery while taking Asperlican because the drug can cause dizziness, headache. Concomitant use of Asperlican with drugs for diabetes, epilepsy, asthma, anticoagulants or other antiviral drugs can interfere with these drugs and cause toxicity. Concomitant administration of Asperlican with rifampicin may reduce the absorption of the fluconazole component and its half-life. Therefore, if you want to use it together, it is necessary to increase the dose of Asperlican. Co-administration of Asperlican with rifabutin or zidovudine in HIV/AIDS patients may increase fluconazole plasma concentrations and rifabutin AUC and its major metabolite. The use of Asperlican is antifungal, especially Candida, which causes disease in the mouth, digestive system as well as the genital organs. Asperlican is also effective in the treatment of systemic candidiasis and other meningitis-causing strains such as Cryptococcus neoformans.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
