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Aripiprazole is in the 1st generation antipsychotic group. Aripiprazole is made in many different forms and strengths. Aripiprazole is used in the treatment and support of some psychotic diseases such as schizophrenia, autism spectrum disorder, ...
1. Uses of Aripiprazole
Aripiprazole belongs to the group of 1st generation antipsychotic drugs. Aripiprazole is prepared in many different forms and strengths:
Tablets with the content of 5mg, 10mg, 15mg and 30mg. Solution for intramuscular injection with a concentration of 7.5 mg/ml. Oral solution with a concentration of 1 mg/ml. Powder for injection and solvent with a concentration of 400mg. Naked tablets dissolve in the mouth with the strength of 10mg, 15mg. Aripiprazole is used in the treatment of schizophrenia, bipolar disorder, Tourette syndrome and supportive treatment of major depressive disorder, autism spectrum disorder.
2. Dosage and how to take Aripiprazole
Aripiprazole in oral solution can be replaced with tablets up to 25mg, but if the patient is already taking the 30mg tablet, the oral solution should be given at 25mg. For the oral tablet form, the dosage is equivalent to that of a regular tablet.
2.1 Aripiprazole Dosage in Adults Oral treatment of schizophrenia: Initial and target dose is 10mg/time/day or 15mg/time/day, higher dose is not synonymous with high effectiveness than. In order for the drug to reach stable concentrations, a minimum dose adjustment of 2 weeks is required. To continue treatment with Aripiprazole, the need for dosing should be reassessed periodically. If remission is continued indefinitely, or can be discontinued, the patient must be closely monitored and if symptoms recur, a re-treatment plan is required. When symptoms are in remission for more than 1 year or the patient's response is maximal, discontinuation of antipsychotic therapy may be considered. If there are 2 or more psychotic episodes within 5 years, indefinite maintenance treatment is required. Maintenance treatment of stable schizophrenia by intramuscular injection: Inject deltoid or gluteal muscle 400 mg/month, interval between injections at least 26 days and continue oral Aripiprazole at 10 - 20 mg /day, used continuously for 2 weeks after the first injection. If the patient is poorly metabolized by CYP2D6, the dose is 300mg/month. Symptomatic control of behavioral disorders and agitation in patients with schizophrenia by intramuscular route: Initial dose is from 5.25 to 15 mg. Or can apply the first dose of Aripiprazole injection is 9.75mg and after 2 hours of injection dose of 5.25-15mg, maximum dose is 3 times/day, maximum total daily dose in case of oral administration and injection is 30mg. Treatment and prophylaxis of manic episodes orally: 15mg/time/day, in case of need can be increased to 30mg/time/day. For the elderly, the dose is the same as for adults. Lower doses may be used in patients with late-onset psychosis or schizophrenia.
2.2 Dosage and administration of Aripiprazole in children Oral treatment of schizophrenia: The target dose in children over 13 years of age is 10mg/time/day. The initial dose should be 2mg/time/day, increased to 5mg/time/day after 2 days and increased to 10mg/time/day after the next 2 days. Each dose increase should only be increased by 5mg/time/day for each episode. For children, the use of high doses (30mg/day) is not effective. To continue treatment with Aripiprazole, need to be reassessed periodically. Oral treatment of manic episodes: The target dose in the treatment of acute exacerbations in children over 10 years of age is 10 mg once daily. Initial dose is 2mg/time/day, after 2 days increase dose to 5mg/time/day and next 2 days increase to target dose of 10mg/time/day. Treatment with Aripiprazole daily can be increased by 5 mg. In children, doses of 10mg and 30mg are effective. 2.3 What happens if you overdose on Aripiprazole? Adult overdose (up to 1260mg) has not been fatal. However, it is possible to have drug poisoning with manifestations such as nausea, vomiting, diarrhea, increased blood pressure, heart palpitations, drowsiness, coma.
Aripiprazole overdose in children (up to 195mg) has not caused any deaths. However, serious drug toxicity can occur with manifestations such as transient loss of consciousness, somnolence, and extrapyramidal symptoms.
In case of overdose, the patient should receive supportive treatment including ventilation, maintaining oxygen and airway, and controlling symptoms. Activated charcoal can be used to treat overdose.
3. Aripiprazole side effects
Aripiprazole can cause some side effects with the following frequency:
Common: Restlessness, anxiety, restlessness, tremors, insomnia, extrapyramidal syndrome, drowsiness, headache, dizziness face, blurred vision, increased salivation, nausea, vomiting, dyspepsia, constipation, fatigue. Uncommon: Restless legs syndrome, tardive dyskinesia, dystonia, depression, hyperglycemia, hyperprolactinemia, increased sexual interest, hiccups, tachycardia, orthostatic hypotension, fear light, double vision. In addition, the drug Aripiprazole also causes some side effects but the frequency has not been determined, including:
Allergic reactions, thrombocytopenia, white blood cells, agranulocytosis. Hyponatremia, diabetes mellitus, increased osmotic coma and ketoacidosis. Suicidal thoughts or attempts at suicide, loss of appetite. The patient is able to successfully commit suicide. Aripiprazole medicine can also cause impulse control disorders, incontinence in eating, shopping, wandering, gambling, agitation, aggression, neuroleptic malignant syndrome, anxiety. Language disorders, serotonin syndrome, ocular dystonia, generalized convulsions, bradycardia, ventricular arrhythmias, cardiac arrest, sudden unexplained death, torsades de pointes. Dysphagia, spasm of the larynx, pharynx, aspiration pneumonia, hypertension, venous thrombosis, pancreatitis, syncope. Aripiprazole may also cause gastrointestinal disturbances, diarrhea, itching, jaundice, hepatitis, liver failure, hirsutism, hair loss, photosensitivity, DRESS syndrome, urinary retention, urinary incontinence, muscle stiffness. , muscle pain, rhabdomyolysis. Weight gain or weight loss, pulmonary edema, chest pain, dysregulation of body temperature, prolonged penile pain, neonatal withdrawal syndrome, some indicators increased. Increased blood sugar, fluctuating blood sugar, increased glycosyl hemoglobin, QT prolongation, increased creatine phosphokinase.
4. Some notes when using Aripiprazole
Do not use Aripiprazole with people who are hypersensitive to the ingredients of the drug. Hypersensitivity reactions may vary from urticaria and pruritus to anaphylaxis. Elderly people with dementia-related psychosis may have an increased risk of death with conventional or typical antipsychotics. Aripiprazole is not used to treat dementia-related psychosis. Adults and children with major depressive disorder with or without antidepressants may experience major depression and/or suicidal ideation, abnormal behavior, and persist until clinical remission occurs. ready. Aripiprazole should be used with caution in patients at risk or intolerant of transient hypotensive episodes, such as cardiovascular disease, cerebrovascular disease, hypovolaemia, use of drugs that decrease heart rate, and lower blood pressure. . Aripiprazole may cause orthostatic hypotension. Aripiprazole should be used with caution in patients with Parkinson's disease because of the potential for exacerbation of movement disorders. Aripiprazole should be used with caution in people at risk for convulsions such as alcoholism, head trauma, brain damage, history of seizures, and concomitant treatment with drugs that lower the seizure threshold. In particular, the elderly, if stimulated when taking the drug, can increase the risk of convulsions. Abrupt discontinuation of Aripiprazole may cause symptoms of a rebound reaction and withdrawal syndrome. Aripiprazole should not be used in pregnant women because it can cause birth defects, increase the risk of adverse reactions such as extrapyramidal symptoms, withdrawal syndrome, especially in the third trimester. pregnancy. Nursing mothers should be considered for treatment with Aripiprazole because it is excreted in breast milk, which may require discontinuation of treatment. Limit the activities of driving, operating machinery while taking the drug because Aripiprazole can cause drowsiness, double vision, blurred vision, sedation, fainting. Aripiprazole is used in the treatment of schizophrenia, bipolar disorder, Tourette's syndrome and as an adjunct in the treatment of major depressive disorder and autism spectrum disorder.
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